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Low coherence interferometry approach for aiding fine needle aspiration biopsies.

Chang EW, Gardecki J, Pitman M, Wilsterman EJ, Patel A, Tearney GJ, Iftimia N - J Biomed Opt (2014)

Bottom Line: We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation.Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.

ABSTRACT
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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Related in: MedlinePlus

(a) Biopsy gun; (b) syringe distal end showing the stilet attached to the plunger; (c) schematic of the modified syringe with the LCI probe passing through the bore of the biopsy needle.
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f2: (a) Biopsy gun; (b) syringe distal end showing the stilet attached to the plunger; (c) schematic of the modified syringe with the LCI probe passing through the bore of the biopsy needle.

Mentions: This instrument uses a specially designed biopsy gun (see Fig. 2) that has a dual functionality: tissue type investigation with LCI and biopsy specimen collection. This dual functionality aspect is extremely important because the specimen has to be collected from the exact same location as the LCI sampling.


Low coherence interferometry approach for aiding fine needle aspiration biopsies.

Chang EW, Gardecki J, Pitman M, Wilsterman EJ, Patel A, Tearney GJ, Iftimia N - J Biomed Opt (2014)

(a) Biopsy gun; (b) syringe distal end showing the stilet attached to the plunger; (c) schematic of the modified syringe with the LCI probe passing through the bore of the biopsy needle.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4222708&req=5

f2: (a) Biopsy gun; (b) syringe distal end showing the stilet attached to the plunger; (c) schematic of the modified syringe with the LCI probe passing through the bore of the biopsy needle.
Mentions: This instrument uses a specially designed biopsy gun (see Fig. 2) that has a dual functionality: tissue type investigation with LCI and biopsy specimen collection. This dual functionality aspect is extremely important because the specimen has to be collected from the exact same location as the LCI sampling.

Bottom Line: We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation.Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

View Article: PubMed Central - PubMed

Affiliation: Physical Sciences, Inc., 20 New England Business Ctr. Drive, Andover, Massachusetts 01810, United States.

ABSTRACT
We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

Show MeSH
Related in: MedlinePlus