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Use of whole genome expression analysis in the toxicity screening of nanoparticles.

Fröhlich E, Meindl C, Wagner K, Leitinger G, Roblegg E - Toxicol. Appl. Pharmacol. (2014)

Bottom Line: Application of lower particle doses and presence of protein decreased the total number of regulated genes but did not markedly influence the top regulated genes.It can be concluded that regulated functions correlated well with results in cell-based assays.Presence of protein mitigated cytotoxicity but did not cause a different pattern of regulated processes.

View Article: PubMed Central - PubMed

Affiliation: Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria. Electronic address: eleonore.froehlich@medunigraz.at.

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Related in: MedlinePlus

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Use of whole genome expression analysis in the toxicity screening of nanoparticles.

Fröhlich E, Meindl C, Wagner K, Leitinger G, Roblegg E - Toxicol. Appl. Pharmacol. (2014)

© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4222661&req=5

Bottom Line: Application of lower particle doses and presence of protein decreased the total number of regulated genes but did not markedly influence the top regulated genes.It can be concluded that regulated functions correlated well with results in cell-based assays.Presence of protein mitigated cytotoxicity but did not cause a different pattern of regulated processes.

View Article: PubMed Central - PubMed

Affiliation: Center for Medical Research, Medical University of Graz, Stiftingtalstr. 24, 8010 Graz, Austria. Electronic address: eleonore.froehlich@medunigraz.at.

Show MeSH
Related in: MedlinePlus