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Low frequency mechanical actuation accelerates reperfusion in-vitro.

Marzencki M, Kajbafzadeh B, Khosrow-Khavar F, Tavakolian K, Soleimani-Nouri M, Hamburger J, Kaminska B, Menon C - Biomed Eng Online (2013)

Bottom Line: Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit.The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced.For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1Faculty of Appliced Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada. cmenon@sfu.ca.

ABSTRACT

Background: Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper evaluates a method of accelerating reperfusion through application of low frequency mechanical stimulus to the blood carrying vessels.

Materials and method: We consider a stenosed, heparinized flow system with aortic-like pressure variations subject to direct vessel vibration at the occlusion site or vessel deformation proximal and distal to the occlusion site, versus a reference system lacking any form of mechanical stimulus on the vessels.

Results: The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced. For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

Conclusion: The presented in-vitro results suggest that low frequency mechanical actuation applied during the pre-hospitalization phase in patients with acute myocardial infarction have potential of being a simple and efficient adjunct therapy.

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Related in: MedlinePlus

Construction of the narrowing. Stenosis site construction, where d1=4.76 mm, d2=1.59 mm and l1=15 mm.
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Figure 3: Construction of the narrowing. Stenosis site construction, where d1=4.76 mm, d2=1.59 mm and l1=15 mm.

Mentions: There was a total of 16 narrowings in the experimental setup used to model stenosis sites, eight for the reference side and eight for the actuated side. Each narrowing in a given setup was identical and created by inserting a 15 mm plastic tube element (narrowing inside in Table 1) into a larger plastic tube (narrowing outside in Table 1), as depicted in Figure 3. In order to insert the smaller tube, the larger tube was cut in half and then glued around the smaller tube with cyanoacrylate glue (Loctite Pro Liquid) and sealed with a silicon glue-sealant (Dow Corning 732). Finally, the tube was cut into proper length and desired proportions before and after the narrowing with a total length of 120 mm. The resulting structure presented a 90% luminal stenosis. Installation of narrowings in the actuated and the reference systems was randomized. The internal diameter and length of the tubing was chosen to correspond to the internal diameter of the human coronary artery, based on the middle section of the right coronary artery [18].


Low frequency mechanical actuation accelerates reperfusion in-vitro.

Marzencki M, Kajbafzadeh B, Khosrow-Khavar F, Tavakolian K, Soleimani-Nouri M, Hamburger J, Kaminska B, Menon C - Biomed Eng Online (2013)

Construction of the narrowing. Stenosis site construction, where d1=4.76 mm, d2=1.59 mm and l1=15 mm.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4222658&req=5

Figure 3: Construction of the narrowing. Stenosis site construction, where d1=4.76 mm, d2=1.59 mm and l1=15 mm.
Mentions: There was a total of 16 narrowings in the experimental setup used to model stenosis sites, eight for the reference side and eight for the actuated side. Each narrowing in a given setup was identical and created by inserting a 15 mm plastic tube element (narrowing inside in Table 1) into a larger plastic tube (narrowing outside in Table 1), as depicted in Figure 3. In order to insert the smaller tube, the larger tube was cut in half and then glued around the smaller tube with cyanoacrylate glue (Loctite Pro Liquid) and sealed with a silicon glue-sealant (Dow Corning 732). Finally, the tube was cut into proper length and desired proportions before and after the narrowing with a total length of 120 mm. The resulting structure presented a 90% luminal stenosis. Installation of narrowings in the actuated and the reference systems was randomized. The internal diameter and length of the tubing was chosen to correspond to the internal diameter of the human coronary artery, based on the middle section of the right coronary artery [18].

Bottom Line: Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit.The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced.For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1Faculty of Appliced Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada. cmenon@sfu.ca.

ABSTRACT

Background: Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper evaluates a method of accelerating reperfusion through application of low frequency mechanical stimulus to the blood carrying vessels.

Materials and method: We consider a stenosed, heparinized flow system with aortic-like pressure variations subject to direct vessel vibration at the occlusion site or vessel deformation proximal and distal to the occlusion site, versus a reference system lacking any form of mechanical stimulus on the vessels.

Results: The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced. For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

Conclusion: The presented in-vitro results suggest that low frequency mechanical actuation applied during the pre-hospitalization phase in patients with acute myocardial infarction have potential of being a simple and efficient adjunct therapy.

Show MeSH
Related in: MedlinePlus