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Low frequency mechanical actuation accelerates reperfusion in-vitro.

Marzencki M, Kajbafzadeh B, Khosrow-Khavar F, Tavakolian K, Soleimani-Nouri M, Hamburger J, Kaminska B, Menon C - Biomed Eng Online (2013)

Bottom Line: Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit.The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced.For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1Faculty of Appliced Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada. cmenon@sfu.ca.

ABSTRACT

Background: Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper evaluates a method of accelerating reperfusion through application of low frequency mechanical stimulus to the blood carrying vessels.

Materials and method: We consider a stenosed, heparinized flow system with aortic-like pressure variations subject to direct vessel vibration at the occlusion site or vessel deformation proximal and distal to the occlusion site, versus a reference system lacking any form of mechanical stimulus on the vessels.

Results: The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced. For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

Conclusion: The presented in-vitro results suggest that low frequency mechanical actuation applied during the pre-hospitalization phase in patients with acute myocardial infarction have potential of being a simple and efficient adjunct therapy.

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Related in: MedlinePlus

Clot mass change. Clot mass change post experiment versus prior to experiment when using setup A. Negative percentage value signifies reduction in clot mass.
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Figure 13: Clot mass change. Clot mass change post experiment versus prior to experiment when using setup A. Negative percentage value signifies reduction in clot mass.

Mentions: Out of 35 tests, only 1 perfusion occurred within the duration of actuation (20 minutes) after 13 minutes on the actuated side resulting in a TIMI 2 flow. Therefore, only the change in the clot masses was evaluated. Figure 13 presents a histogram of clot mass changes evaluated as the difference between the clot mass post experiment versus the clot mass prior to the experiment. The average mass change is -15.89% (σ=26.4%) for the reference system and -12.16% (σ=19.1%) for the actuated system. The fact that mass of some clots increased may be due to water absorption, or imperfect soaking method employed.


Low frequency mechanical actuation accelerates reperfusion in-vitro.

Marzencki M, Kajbafzadeh B, Khosrow-Khavar F, Tavakolian K, Soleimani-Nouri M, Hamburger J, Kaminska B, Menon C - Biomed Eng Online (2013)

Clot mass change. Clot mass change post experiment versus prior to experiment when using setup A. Negative percentage value signifies reduction in clot mass.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4222658&req=5

Figure 13: Clot mass change. Clot mass change post experiment versus prior to experiment when using setup A. Negative percentage value signifies reduction in clot mass.
Mentions: Out of 35 tests, only 1 perfusion occurred within the duration of actuation (20 minutes) after 13 minutes on the actuated side resulting in a TIMI 2 flow. Therefore, only the change in the clot masses was evaluated. Figure 13 presents a histogram of clot mass changes evaluated as the difference between the clot mass post experiment versus the clot mass prior to the experiment. The average mass change is -15.89% (σ=26.4%) for the reference system and -12.16% (σ=19.1%) for the actuated system. The fact that mass of some clots increased may be due to water absorption, or imperfect soaking method employed.

Bottom Line: Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit.The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced.For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1Faculty of Appliced Science, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada. cmenon@sfu.ca.

ABSTRACT

Background: Rapid restoration of vessel patency after acute myocardial infarction is key to reducing myocardial muscle death and increases survival rates. Standard therapies include thrombolysis and direct PTCA. Alternative or adjunctive emergency therapies that could be initiated by minimally trained personnel in the field are of potential clinical benefit. This paper evaluates a method of accelerating reperfusion through application of low frequency mechanical stimulus to the blood carrying vessels.

Materials and method: We consider a stenosed, heparinized flow system with aortic-like pressure variations subject to direct vessel vibration at the occlusion site or vessel deformation proximal and distal to the occlusion site, versus a reference system lacking any form of mechanical stimulus on the vessels.

Results: The experimental results show limited effectiveness of the direct mechanical vibration method and a drastic increase in the patency rate when vessel deformation is induced. For vessel deformation at occlusion site 95% of clots perfused within 11 minutes of application of mechanical stimulus, for vessel deformation 60 centimeters from the occlusion site 95% percent of clots perfused within 16 minutes of stimulus application, while only 2.3% of clots perfused within 20 minutes in the reference system.

Conclusion: The presented in-vitro results suggest that low frequency mechanical actuation applied during the pre-hospitalization phase in patients with acute myocardial infarction have potential of being a simple and efficient adjunct therapy.

Show MeSH
Related in: MedlinePlus