Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
Bottom Line: In this study, genome-wide association results of hearing function from the G-EAR consortium and TwinsUK were used for meta-analysis.A single SNP lying in intron 6 of the salt-inducible kinase 3 (SIK3) gene was found to be associated with hearing PC2 (P = 3.7×10(-8)) and further supported by whole-genome sequence in a subset.Our results suggest a developmental role of Sik3 in hearing and may be required for the maintenance of adult auditory function.
Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.Show MeSH
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Mentions: Sik3 was highly expressed at all three developmental stages studied in the mouse: at the day of birth as well as 5 days postnatal, expression of Sik3 was limited to the tops of the inner and outer hair cells in the cochlea, non-neuronal cells of the spiral ganglion, cells in the intermediate layer of the stria vascularis and the perilymph-facing layer of the Reissner's membrane (Fig. 3). In the stria vascularis, Sik3 was expressed near blood vessels in the intermediate layer. These cells have previously been described as macrophage-like melanocytes (25). At 4 weeks after birth, Sik3 expression could no longer be detected in the hair cells, indicating that this expression was limited to early developmental stages. Expression in the spiral ganglion and stria vascularis remained even 4 weeks after birth (Fig. 3).Figure 3.
Affiliation: Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.