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Stereoscopic three-dimensional visualization applied to multimodal brain images: clinical applications and a functional connectivity atlas.

Rojas GM, Gálvez M, Vega Potler N, Craddock RC, Margulies DS, Castellanos FX, Milham MP - Front Neurosci (2014)

Bottom Line: We present here results of stereoscopic visualization of clinical data, as well as an atlas of whole-brain functional connectivity.In the case of resting state fMRI, stereoscopic 3D visualization facilitated comprehension of the anatomical position of complex large-scale functional connectivity patterns.Overall, stereoscopic visualization improves the intuitive visual comprehension of image contents, and brings increased dimensionality to visualization of traditional MRI data, as well as patterns of functional connectivity.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Advanced Medical Image Processing, Department of Radiology, Clínica las Condes Santiago, Chile ; Advanced Epilepsy Center, Clínica las Condes Santiago, Chile.

ABSTRACT
Effective visualization is central to the exploration and comprehension of brain imaging data. While MRI data are acquired in three-dimensional space, the methods for visualizing such data have rarely taken advantage of three-dimensional stereoscopic technologies. We present here results of stereoscopic visualization of clinical data, as well as an atlas of whole-brain functional connectivity. In comparison with traditional 3D rendering techniques, we demonstrate the utility of stereoscopic visualizations to provide an intuitive description of the exact location and the relative sizes of various brain landmarks, structures and lesions. In the case of resting state fMRI, stereoscopic 3D visualization facilitated comprehension of the anatomical position of complex large-scale functional connectivity patterns. Overall, stereoscopic visualization improves the intuitive visual comprehension of image contents, and brings increased dimensionality to visualization of traditional MRI data, as well as patterns of functional connectivity.

No MeSH data available.


Related in: MedlinePlus

Anatomical slices of each patient showing different type of lesions. (A) P1: T2 weighted coronal slice. The right hippocampus volume is reduced. (B) P2: T2 weighted coronal slice. Slight decrease in right hippocampus volume. (C) P3: T1 weighted axial slice showing right precentral tumor. (D) P4: T2- FLAIR axial image showing a right temporal porencephalic cyst. (E) P5: T2 weighted axial slice of a patient with a medulla oblongata cavernoma in brainstem. (F) P6: T2-FLAIR of a left frontal glioma patient. (G) P7: PD axial slice of a MS patient. (H) P8: T2 weighted axial slice of a MS patient.
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Figure 1: Anatomical slices of each patient showing different type of lesions. (A) P1: T2 weighted coronal slice. The right hippocampus volume is reduced. (B) P2: T2 weighted coronal slice. Slight decrease in right hippocampus volume. (C) P3: T1 weighted axial slice showing right precentral tumor. (D) P4: T2- FLAIR axial image showing a right temporal porencephalic cyst. (E) P5: T2 weighted axial slice of a patient with a medulla oblongata cavernoma in brainstem. (F) P6: T2-FLAIR of a left frontal glioma patient. (G) P7: PD axial slice of a MS patient. (H) P8: T2 weighted axial slice of a MS patient.

Mentions: For case P5, a 63 year-old female patient with a medulla oblongata cavernoma, a diffusion tensor imaging (DTI) sequence (single-shot diffusion-weighted spin-echo EPI sequence, TR = 7100 ms, TE = 96 ms, matrix = 116 × 116, FOV = 230 × 230 mm, slice thickness 2.2 mm, gap = 0.8 mm, 50 contiguous sections, b = 1000 s/mm2, 30 non-collinear directions), a high resolution isotropic T1-weighted magnetization prepared gradient echo sequence was acquired with the same parameters as cases P1-P4, and post gadolinium isotropic T1-weighted images (T1-GD, sagittal images, 256 × 256 × 160, 1 mm3 isotropic spatial resolution, TI = 1100 ms, TR = 2060 ms, TE = 3.25 ms, flip angle = 15°) were collected. See standard T2-weighted image in Figure 1E. The tractography was processed using 3D Slicer 3.6.3 software. The T1-GD, T1 and DTI were coregistered with the 3D Slicer linear registration algorithm, and the cavernoma was segmented using a T1-GD sequence with a simple region-growing algorithm, which was then used to create a 3D model of the cavernoma using the Model Maker module of 3D Slicer.


Stereoscopic three-dimensional visualization applied to multimodal brain images: clinical applications and a functional connectivity atlas.

Rojas GM, Gálvez M, Vega Potler N, Craddock RC, Margulies DS, Castellanos FX, Milham MP - Front Neurosci (2014)

Anatomical slices of each patient showing different type of lesions. (A) P1: T2 weighted coronal slice. The right hippocampus volume is reduced. (B) P2: T2 weighted coronal slice. Slight decrease in right hippocampus volume. (C) P3: T1 weighted axial slice showing right precentral tumor. (D) P4: T2- FLAIR axial image showing a right temporal porencephalic cyst. (E) P5: T2 weighted axial slice of a patient with a medulla oblongata cavernoma in brainstem. (F) P6: T2-FLAIR of a left frontal glioma patient. (G) P7: PD axial slice of a MS patient. (H) P8: T2 weighted axial slice of a MS patient.
© Copyright Policy - open-access
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4222226&req=5

Figure 1: Anatomical slices of each patient showing different type of lesions. (A) P1: T2 weighted coronal slice. The right hippocampus volume is reduced. (B) P2: T2 weighted coronal slice. Slight decrease in right hippocampus volume. (C) P3: T1 weighted axial slice showing right precentral tumor. (D) P4: T2- FLAIR axial image showing a right temporal porencephalic cyst. (E) P5: T2 weighted axial slice of a patient with a medulla oblongata cavernoma in brainstem. (F) P6: T2-FLAIR of a left frontal glioma patient. (G) P7: PD axial slice of a MS patient. (H) P8: T2 weighted axial slice of a MS patient.
Mentions: For case P5, a 63 year-old female patient with a medulla oblongata cavernoma, a diffusion tensor imaging (DTI) sequence (single-shot diffusion-weighted spin-echo EPI sequence, TR = 7100 ms, TE = 96 ms, matrix = 116 × 116, FOV = 230 × 230 mm, slice thickness 2.2 mm, gap = 0.8 mm, 50 contiguous sections, b = 1000 s/mm2, 30 non-collinear directions), a high resolution isotropic T1-weighted magnetization prepared gradient echo sequence was acquired with the same parameters as cases P1-P4, and post gadolinium isotropic T1-weighted images (T1-GD, sagittal images, 256 × 256 × 160, 1 mm3 isotropic spatial resolution, TI = 1100 ms, TR = 2060 ms, TE = 3.25 ms, flip angle = 15°) were collected. See standard T2-weighted image in Figure 1E. The tractography was processed using 3D Slicer 3.6.3 software. The T1-GD, T1 and DTI were coregistered with the 3D Slicer linear registration algorithm, and the cavernoma was segmented using a T1-GD sequence with a simple region-growing algorithm, which was then used to create a 3D model of the cavernoma using the Model Maker module of 3D Slicer.

Bottom Line: We present here results of stereoscopic visualization of clinical data, as well as an atlas of whole-brain functional connectivity.In the case of resting state fMRI, stereoscopic 3D visualization facilitated comprehension of the anatomical position of complex large-scale functional connectivity patterns.Overall, stereoscopic visualization improves the intuitive visual comprehension of image contents, and brings increased dimensionality to visualization of traditional MRI data, as well as patterns of functional connectivity.

View Article: PubMed Central - PubMed

Affiliation: Laboratory for Advanced Medical Image Processing, Department of Radiology, Clínica las Condes Santiago, Chile ; Advanced Epilepsy Center, Clínica las Condes Santiago, Chile.

ABSTRACT
Effective visualization is central to the exploration and comprehension of brain imaging data. While MRI data are acquired in three-dimensional space, the methods for visualizing such data have rarely taken advantage of three-dimensional stereoscopic technologies. We present here results of stereoscopic visualization of clinical data, as well as an atlas of whole-brain functional connectivity. In comparison with traditional 3D rendering techniques, we demonstrate the utility of stereoscopic visualizations to provide an intuitive description of the exact location and the relative sizes of various brain landmarks, structures and lesions. In the case of resting state fMRI, stereoscopic 3D visualization facilitated comprehension of the anatomical position of complex large-scale functional connectivity patterns. Overall, stereoscopic visualization improves the intuitive visual comprehension of image contents, and brings increased dimensionality to visualization of traditional MRI data, as well as patterns of functional connectivity.

No MeSH data available.


Related in: MedlinePlus