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GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinson's disease.

Hall SD, Prokic EJ, McAllister CJ, Ronnqvist KC, Williams AC, Yamawaki N, Witton C, Woodhall GL, Stanford IM - Neuroscience (2014)

Bottom Line: In PD patients, contralateral M1 showed significantly greater beta power than ipsilateral M1.Following zolpidem administration contralateral beta power was significantly reduced while ipsilateral beta power was significantly increased resulting in a hemispheric power ratio that approached parity.These results show that low-dose zolpidem not only reduces contralateral beta but also increases ipsilateral beta, while rebalancing the dynamic range of M1 network oscillations between the two hemispheres.

View Article: PubMed Central - PubMed

Affiliation: Aston Brain Centre, Aston University, Birmingham, West Midlands, UK; School of Psychology, Plymouth University, Devon, UK.

No MeSH data available.


Related in: MedlinePlus

Improvements in UPDRS following zolpidem administration. (left panel) Group mean UPDRS score (part III) before (dark) and after (light) zolpidem administration (0.05 mg/kg). (right panel) Group mean UPDRS scores for individual items before and after zolpidem administration.
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f0010: Improvements in UPDRS following zolpidem administration. (left panel) Group mean UPDRS score (part III) before (dark) and after (light) zolpidem administration (0.05 mg/kg). (right panel) Group mean UPDRS scores for individual items before and after zolpidem administration.

Mentions: Assessment with the UPDRS confirmed that all nine PD patients presented with unilaterally dominant symptoms with varied levels of severity (UPDRS: mean 14.25 ± 5.0). In all cases, following zolpidem improvements were observed in the overall severity of the symptoms observed (UPDRS improvement: mean 7.5 ± 1.9; p = 0.006). Analysis of category revealed significant improvements in all UPDRS items except 14-speech (Fig. 2). Anecdotally, improvements were also observed in handwriting ability as noted from patient report and observation of consent form signatures obtained prior to MEG acquisition (pre-drug) and prior to MRI acquisition (post-drug).


GABA-mediated changes in inter-hemispheric beta frequency activity in early-stage Parkinson's disease.

Hall SD, Prokic EJ, McAllister CJ, Ronnqvist KC, Williams AC, Yamawaki N, Witton C, Woodhall GL, Stanford IM - Neuroscience (2014)

Improvements in UPDRS following zolpidem administration. (left panel) Group mean UPDRS score (part III) before (dark) and after (light) zolpidem administration (0.05 mg/kg). (right panel) Group mean UPDRS scores for individual items before and after zolpidem administration.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4222199&req=5

f0010: Improvements in UPDRS following zolpidem administration. (left panel) Group mean UPDRS score (part III) before (dark) and after (light) zolpidem administration (0.05 mg/kg). (right panel) Group mean UPDRS scores for individual items before and after zolpidem administration.
Mentions: Assessment with the UPDRS confirmed that all nine PD patients presented with unilaterally dominant symptoms with varied levels of severity (UPDRS: mean 14.25 ± 5.0). In all cases, following zolpidem improvements were observed in the overall severity of the symptoms observed (UPDRS improvement: mean 7.5 ± 1.9; p = 0.006). Analysis of category revealed significant improvements in all UPDRS items except 14-speech (Fig. 2). Anecdotally, improvements were also observed in handwriting ability as noted from patient report and observation of consent form signatures obtained prior to MEG acquisition (pre-drug) and prior to MRI acquisition (post-drug).

Bottom Line: In PD patients, contralateral M1 showed significantly greater beta power than ipsilateral M1.Following zolpidem administration contralateral beta power was significantly reduced while ipsilateral beta power was significantly increased resulting in a hemispheric power ratio that approached parity.These results show that low-dose zolpidem not only reduces contralateral beta but also increases ipsilateral beta, while rebalancing the dynamic range of M1 network oscillations between the two hemispheres.

View Article: PubMed Central - PubMed

Affiliation: Aston Brain Centre, Aston University, Birmingham, West Midlands, UK; School of Psychology, Plymouth University, Devon, UK.

No MeSH data available.


Related in: MedlinePlus