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Presurgical therapy with axitinib for advanced renal cell carcinoma: a case report.

Koie T, Ohyama C, Okamoto A, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y - BMC Res Notes (2013)

Bottom Line: No serious adverse events were reported during this treatment.Pathological examination indicated a pT3aN0M0, Furman grade 3, clear cell renal cell carcinoma with necrosis, hyaline degeneration, and hemosiderosis.The patient was asymptomatic and disease-free at 1 year post-diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki 036-8562, Japan. coyama@cc.hirosaki-u.ac.jp.

ABSTRACT

Background: Targeted therapy with tyrosine kinase inhibitors has been shown to reduce tumor volumes and prolong the survival of patients with metastatic renal cell carcinoma. Tyrosine kinase inhibitors, particularly sunitinib, have recently been used in neoadjuvant and presurgical settings. Axitinib is a promising second-line therapy option for advanced or metastatic renal cell carcinoma. Herein, we report a patient with advanced renal cell carcinoma who received presurgical treatment with axitinib.

Case presentation: A 73-year-old man was transported by ambulance to a community hospital with chief complaints of high fever and a gait disorder. Computed tomography screening revealed a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney. Upon admission to our hospital, his general condition was poor and his performance status was judged as 3, based on the Eastern Cooperative Oncology Group performance status criteria. After biopsy for the renal tumor, he received 5 mg of axitinib twice daily for 3 months. No serious adverse events were reported during this treatment. The tumor diameter shrank by 56%. Left radical nephrectomy was performed, and there were no intraoperative or postoperative complications. Pathological examination indicated a pT3aN0M0, Furman grade 3, clear cell renal cell carcinoma with necrosis, hyaline degeneration, and hemosiderosis. The patient was asymptomatic and disease-free at 1 year post-diagnosis.

Conclusion: This case study demonstrate that presurgical therapy with axitinib is feasible and might have several potential advantages for patients with advanced renal cell carcinoma.

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Abdominal enhanced computed tomography (CT) before axitinib treatment. (coronal section) Abdominal CT shows a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney.
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Figure 1: Abdominal enhanced computed tomography (CT) before axitinib treatment. (coronal section) Abdominal CT shows a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney.

Mentions: A 73-year-old man was transported by ambulance to a community hospital with chief complaints of high fever and a gait disorder. Laboratory evaluations revealed the following findings: hemoglobin, 7.0 g/dL (normal range, 13.5-17.5 g/dL); creatine phosphokinase, 572 IU/L (normal range, 60-270 IU/L); free blood sugar, 226 mg/dL (normal range, 70-109 mg/dL); and C-reactive protein, 14.0 mg/dL (normal range, <0.3 mg/dL). Computed tomography (CT) screening revealed a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney (Figure 1). The tumor was clinically diagnosed as a left RCC with a classification of cT2aN0M0, according to the tumor-node-metastasis system [7]. The patient was transferred to our hospital for surgical treatment.


Presurgical therapy with axitinib for advanced renal cell carcinoma: a case report.

Koie T, Ohyama C, Okamoto A, Yamamoto H, Imai A, Hatakeyama S, Yoneyama T, Hashimoto Y - BMC Res Notes (2013)

Abdominal enhanced computed tomography (CT) before axitinib treatment. (coronal section) Abdominal CT shows a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4222084&req=5

Figure 1: Abdominal enhanced computed tomography (CT) before axitinib treatment. (coronal section) Abdominal CT shows a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney.
Mentions: A 73-year-old man was transported by ambulance to a community hospital with chief complaints of high fever and a gait disorder. Laboratory evaluations revealed the following findings: hemoglobin, 7.0 g/dL (normal range, 13.5-17.5 g/dL); creatine phosphokinase, 572 IU/L (normal range, 60-270 IU/L); free blood sugar, 226 mg/dL (normal range, 70-109 mg/dL); and C-reactive protein, 14.0 mg/dL (normal range, <0.3 mg/dL). Computed tomography (CT) screening revealed a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney (Figure 1). The tumor was clinically diagnosed as a left RCC with a classification of cT2aN0M0, according to the tumor-node-metastasis system [7]. The patient was transferred to our hospital for surgical treatment.

Bottom Line: No serious adverse events were reported during this treatment.Pathological examination indicated a pT3aN0M0, Furman grade 3, clear cell renal cell carcinoma with necrosis, hyaline degeneration, and hemosiderosis.The patient was asymptomatic and disease-free at 1 year post-diagnosis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifucho, Hirosaki 036-8562, Japan. coyama@cc.hirosaki-u.ac.jp.

ABSTRACT

Background: Targeted therapy with tyrosine kinase inhibitors has been shown to reduce tumor volumes and prolong the survival of patients with metastatic renal cell carcinoma. Tyrosine kinase inhibitors, particularly sunitinib, have recently been used in neoadjuvant and presurgical settings. Axitinib is a promising second-line therapy option for advanced or metastatic renal cell carcinoma. Herein, we report a patient with advanced renal cell carcinoma who received presurgical treatment with axitinib.

Case presentation: A 73-year-old man was transported by ambulance to a community hospital with chief complaints of high fever and a gait disorder. Computed tomography screening revealed a hypervascular tumor (size, 9 × 8.5 cm) in the lower pole of the left kidney. Upon admission to our hospital, his general condition was poor and his performance status was judged as 3, based on the Eastern Cooperative Oncology Group performance status criteria. After biopsy for the renal tumor, he received 5 mg of axitinib twice daily for 3 months. No serious adverse events were reported during this treatment. The tumor diameter shrank by 56%. Left radical nephrectomy was performed, and there were no intraoperative or postoperative complications. Pathological examination indicated a pT3aN0M0, Furman grade 3, clear cell renal cell carcinoma with necrosis, hyaline degeneration, and hemosiderosis. The patient was asymptomatic and disease-free at 1 year post-diagnosis.

Conclusion: This case study demonstrate that presurgical therapy with axitinib is feasible and might have several potential advantages for patients with advanced renal cell carcinoma.

Show MeSH
Related in: MedlinePlus