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A comparison of second and third generations combined oral contraceptive pills' effect on mood.

Shahnazi M, Farshbaf Khalili A, Ranjbar Kochaksaraei F, Asghari Jafarabadi M, Gaza Banoi K, Nahaee J, Bayati Payan S - Iran Red Crescent Med J (2014)

Bottom Line: This study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women.The second generation oral contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to 38.32 in second month and 43.39 to 26.05 in four month) and increase in negative mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P < 0.001), but the third generation led to an increase in positive mood (95% CI: 22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four month - P < 0.001).Third generation combined oral contraceptive pills have a better effect on mood in women in reproductive ages than the second generation pills.

View Article: PubMed Central - PubMed

Affiliation: Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran.

ABSTRACT

Background: Most women taking combined oral contraceptives (COCs) are satisfied with their contraceptive method. However, one of the most common reasons reported for discontinuation of combined oral contraceptives (COCs) is mood deterioration.

Objectives: This study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women.

Materials and methods: This randomized, double-blind, controlled clinical trial was conducted in reproductive women at health centers in Tehran, Iran. Participants were randomized into the second and third generation oral contraceptive groups. Positive and negative moods were recorded using positive affect, negative affect scale (PANAS) tools at the end the second and fourth months of the study. Data analysis was carried out using ANOVA and P Values < 0.05 was considered significant.

Results: Statistically significant difference was seen in positive and negative mood changes in women receiving contraceptive pills. The second generation oral contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to 38.32 in second month and 43.39 to 26.05 in four month) and increase in negative mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P < 0.001), but the third generation led to an increase in positive mood (95% CI: 22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four month - P < 0.001).

Conclusions: Third generation combined oral contraceptive pills have a better effect on mood in women in reproductive ages than the second generation pills. It can be recommended as a proper combined oral contraceptive in Iran.

No MeSH data available.


Related in: MedlinePlus

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fig12545: Study Protocol

Mentions: In this study, 102 women in their reproductive age who wished to participate in the study were selected. Twenty women were excluded from the study because they did not meet the inclusion criteria. Therefore, the study was conducted on 82 women in their reproductive age in two groups of 41; one group received second-generation oral contraceptives (LD™) and the second group received third-generation oral contraceptives (Marvelon®) (Figure 1). There was no loss to follow-up and all participants continued the study to the end. Both groups were similar in terms of the personal and social characteristics, the average age in the group receiving second generation and third generation was 29 ± 7.01 and 28 ± 7.93 years, respectively. The majority (34.1%) of patients in both groups had secondary school education and the majority of patients in the group receiving second generation pills (34.1%) were housewives and in the group receiving third generation (34.1%) worked at home, other personal and social characteristics are shown in (Table 1).


A comparison of second and third generations combined oral contraceptive pills' effect on mood.

Shahnazi M, Farshbaf Khalili A, Ranjbar Kochaksaraei F, Asghari Jafarabadi M, Gaza Banoi K, Nahaee J, Bayati Payan S - Iran Red Crescent Med J (2014)

Study Protocol
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4222004&req=5

fig12545: Study Protocol
Mentions: In this study, 102 women in their reproductive age who wished to participate in the study were selected. Twenty women were excluded from the study because they did not meet the inclusion criteria. Therefore, the study was conducted on 82 women in their reproductive age in two groups of 41; one group received second-generation oral contraceptives (LD™) and the second group received third-generation oral contraceptives (Marvelon®) (Figure 1). There was no loss to follow-up and all participants continued the study to the end. Both groups were similar in terms of the personal and social characteristics, the average age in the group receiving second generation and third generation was 29 ± 7.01 and 28 ± 7.93 years, respectively. The majority (34.1%) of patients in both groups had secondary school education and the majority of patients in the group receiving second generation pills (34.1%) were housewives and in the group receiving third generation (34.1%) worked at home, other personal and social characteristics are shown in (Table 1).

Bottom Line: This study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women.The second generation oral contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to 38.32 in second month and 43.39 to 26.05 in four month) and increase in negative mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P < 0.001), but the third generation led to an increase in positive mood (95% CI: 22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four month - P < 0.001).Third generation combined oral contraceptive pills have a better effect on mood in women in reproductive ages than the second generation pills.

View Article: PubMed Central - PubMed

Affiliation: Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, IR Iran.

ABSTRACT

Background: Most women taking combined oral contraceptives (COCs) are satisfied with their contraceptive method. However, one of the most common reasons reported for discontinuation of combined oral contraceptives (COCs) is mood deterioration.

Objectives: This study aimed to compare effects of the second and third generation oral contraceptive pills on the mood of reproductive women.

Materials and methods: This randomized, double-blind, controlled clinical trial was conducted in reproductive women at health centers in Tehran, Iran. Participants were randomized into the second and third generation oral contraceptive groups. Positive and negative moods were recorded using positive affect, negative affect scale (PANAS) tools at the end the second and fourth months of the study. Data analysis was carried out using ANOVA and P Values < 0.05 was considered significant.

Results: Statistically significant difference was seen in positive and negative mood changes in women receiving contraceptive pills. The second generation oral contraceptive pills resulted in a decrease in positive mood (95% CI: 43.39 to 38.32 in second month and 43.39 to 26.05 in four month) and increase in negative mood (95% CI: 14.23 to 22.04 in second month and 14.23 to 32.26 in four month - P < 0.001), but the third generation led to an increase in positive mood (95% CI: 22.42 to 25.60 in second month and 22.42 to 33.87 in four month) and decrease in negative mood (95% CI: 36.78 to 31.97 in second month and 36.78 to 22.65 in four month - P < 0.001).

Conclusions: Third generation combined oral contraceptive pills have a better effect on mood in women in reproductive ages than the second generation pills. It can be recommended as a proper combined oral contraceptive in Iran.

No MeSH data available.


Related in: MedlinePlus