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The neuroprotective effect of cornus MAS on brain tissue of Wistar rats.

Francik R, Kryczyk J, Krośniak M, Berköz M, Sanocka I, Francik S - ScientificWorldJournal (2014)

Bottom Line: This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups.Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect.Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioorganic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland ; State Higher Vocational School, Institute of Health, Staszica 1 Street, 33-300 Nowy Sacz, Poland.

ABSTRACT
Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer's disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.

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Related in: MedlinePlus

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Mentions: In brain tissue of the animals fed with the fructose or high-fat (lard) diet (Table 2, Figure 3), a statistically significant increase of the FRAP value was observed in comparison to the control group. Adding cornelian cherry to the fructose or high-fat diet caused a statistically significant decrease of the FRAP value in comparison to the groups which did not receive the cornelian cherry addition. The results were different in the control group where the addition of cornelian cherry caused a statistically significant increase of the discussed parameter in comparison to the control diet without this addition. In plasma, the addition of cornelian cherry caused a statistically significant increase of the FRAP value in the control and fructose diet groups.


The neuroprotective effect of cornus MAS on brain tissue of Wistar rats.

Francik R, Kryczyk J, Krośniak M, Berköz M, Sanocka I, Francik S - ScientificWorldJournal (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4221989&req=5

Mentions: In brain tissue of the animals fed with the fructose or high-fat (lard) diet (Table 2, Figure 3), a statistically significant increase of the FRAP value was observed in comparison to the control group. Adding cornelian cherry to the fructose or high-fat diet caused a statistically significant decrease of the FRAP value in comparison to the groups which did not receive the cornelian cherry addition. The results were different in the control group where the addition of cornelian cherry caused a statistically significant increase of the discussed parameter in comparison to the control diet without this addition. In plasma, the addition of cornelian cherry caused a statistically significant increase of the FRAP value in the control and fructose diet groups.

Bottom Line: This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups.Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect.Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.

View Article: PubMed Central - PubMed

Affiliation: Department of Bioorganic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Krakow, Poland ; State Higher Vocational School, Institute of Health, Staszica 1 Street, 33-300 Nowy Sacz, Poland.

ABSTRACT
Cornelian cherry (Cornus mas) is a valuable source of phenolic antioxidants. Flavonoid derivatives as nonenzymatic antioxidants are important in the pathophysiology of many diseases including neurological disorders (e.g., Alzheimer's disease) or heart disease. In this study, we examined the effect of an addition of freeze-dried fruit of cornelian cherry on three types of diets: control diet, fructose diet, and diet enriched in fats (high-fat diet). This effect was studied by determining the following antioxidant parameters in both brain tissue and plasma in rats: catalase, ferric reducing ability of plasma, paraoxonase, protein carbonyl groups, and free thiol groups. Results indicate that both fructose diet and high-fat diet affect the antioxidant capacity of the organism. Furthermore, an addition of cornelian cherry resulted in increased activity of catalase in brain tissue, while in plasma it caused the opposite effect. In turn, with regard to paraoxonase activity in both brain tissue and plasma, it had a stimulating effect. Adding cornelian cherry to the tested diets increased the activity of PON in both tested tissues. Moreover, protective effect of fruits of this plant was observed in the process of oxidation of proteins by decreasing levels of protein carbonyl groups and thiol groups in brain tissue as well as in plasma.

Show MeSH
Related in: MedlinePlus