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Translational geroscience: emphasizing function to achieve optimal longevity.

Seals DR, Melov S - Aging (Albany NY) (2014)

Bottom Line: This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences.To meet this demand, investigators with interests in the biological aspects of aging from model organisms to human epidemiology (population aging) must work together within an interactive process that we describe astranslational geroscience.To most effectively utilize this new approach, we must rethink how investigators and administrators working at different levels of the translational research continuum communicate and collaborate with each other, how best to train the next generation of scientists in this new field, and how contemporary biological-biomedical aging research should be organized and funded.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.

ABSTRACT
Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability. This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences. Superimposed on this setting are the adults now reaching traditional retirement ages--the baby boomers--a group that wishes to remain active, productive and physically and cognitively fit as they grow older. Together, these conditions are producing an unprecedented demand for increased healthspan or what might be termed "optimal longevity"-to live long, but well. To meet this demand, investigators with interests in the biological aspects of aging from model organisms to human epidemiology (population aging) must work together within an interactive process that we describe astranslational geroscience. An essential goal of this new investigational platform should be the optimization and preservation of physiological function throughout the lifespan, including integrative physical and cognitive function, which would serve to increase healthspan, compress morbidity and disability into a shorter period of late-life, and help achieve optimal longevity. To most effectively utilize this new approach, we must rethink how investigators and administrators working at different levels of the translational research continuum communicate and collaborate with each other, how best to train the next generation of scientists in this new field, and how contemporary biological-biomedical aging research should be organized and funded.

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Translational geroscienceTranslational gero-science represents an integrative model for conducting biological-biomedical aging research leveraging a bi-directional, continuum of observations from basic science to populations using multidisciplinary approaches.
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Figure 3: Translational geroscienceTranslational gero-science represents an integrative model for conducting biological-biomedical aging research leveraging a bi-directional, continuum of observations from basic science to populations using multidisciplinary approaches.

Mentions: Adopting a more multidisciplinary translational approach to biomedical aging research requires a mutual understanding of the concept of translational research. Some scientists hold the traditional perspective of translational research as a unidirectional process in which original (discovery) observations are made in the basic science laboratory and subsequently extended to humans, often culminating in a clinical trial. In contemporary views, however, translational research refers to a continuum in which observations made in preclinical models are first translated to humans in a clinical research setting (bench to bedside) and then to the clinic, eventually resulting in new medical guidelines and public health policy (bedside to community) [27, 28]. Importantly, the translational process is intended to be dynamic and bi-directionaI. Indeed, current translational research constructs emphasize the value of making discovery observations at the clinical or even population level and “reverse translating” to basic science models to discern the underlying mechanisms and identify promising interventions. Extending this concept to biological aging, translational geroscience can be viewed as a bi-directional continuum that includes investigation from the fundamental mechanisms of aging using basic model organisms to population aging studied in community settings, with the ultimate goal being optimal longevity (Figure 3).


Translational geroscience: emphasizing function to achieve optimal longevity.

Seals DR, Melov S - Aging (Albany NY) (2014)

Translational geroscienceTranslational gero-science represents an integrative model for conducting biological-biomedical aging research leveraging a bi-directional, continuum of observations from basic science to populations using multidisciplinary approaches.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221919&req=5

Figure 3: Translational geroscienceTranslational gero-science represents an integrative model for conducting biological-biomedical aging research leveraging a bi-directional, continuum of observations from basic science to populations using multidisciplinary approaches.
Mentions: Adopting a more multidisciplinary translational approach to biomedical aging research requires a mutual understanding of the concept of translational research. Some scientists hold the traditional perspective of translational research as a unidirectional process in which original (discovery) observations are made in the basic science laboratory and subsequently extended to humans, often culminating in a clinical trial. In contemporary views, however, translational research refers to a continuum in which observations made in preclinical models are first translated to humans in a clinical research setting (bench to bedside) and then to the clinic, eventually resulting in new medical guidelines and public health policy (bedside to community) [27, 28]. Importantly, the translational process is intended to be dynamic and bi-directionaI. Indeed, current translational research constructs emphasize the value of making discovery observations at the clinical or even population level and “reverse translating” to basic science models to discern the underlying mechanisms and identify promising interventions. Extending this concept to biological aging, translational geroscience can be viewed as a bi-directional continuum that includes investigation from the fundamental mechanisms of aging using basic model organisms to population aging studied in community settings, with the ultimate goal being optimal longevity (Figure 3).

Bottom Line: This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences.To meet this demand, investigators with interests in the biological aspects of aging from model organisms to human epidemiology (population aging) must work together within an interactive process that we describe astranslational geroscience.To most effectively utilize this new approach, we must rethink how investigators and administrators working at different levels of the translational research continuum communicate and collaborate with each other, how best to train the next generation of scientists in this new field, and how contemporary biological-biomedical aging research should be organized and funded.

View Article: PubMed Central - PubMed

Affiliation: Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA.

ABSTRACT
Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability. This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences. Superimposed on this setting are the adults now reaching traditional retirement ages--the baby boomers--a group that wishes to remain active, productive and physically and cognitively fit as they grow older. Together, these conditions are producing an unprecedented demand for increased healthspan or what might be termed "optimal longevity"-to live long, but well. To meet this demand, investigators with interests in the biological aspects of aging from model organisms to human epidemiology (population aging) must work together within an interactive process that we describe astranslational geroscience. An essential goal of this new investigational platform should be the optimization and preservation of physiological function throughout the lifespan, including integrative physical and cognitive function, which would serve to increase healthspan, compress morbidity and disability into a shorter period of late-life, and help achieve optimal longevity. To most effectively utilize this new approach, we must rethink how investigators and administrators working at different levels of the translational research continuum communicate and collaborate with each other, how best to train the next generation of scientists in this new field, and how contemporary biological-biomedical aging research should be organized and funded.

Show MeSH
Related in: MedlinePlus