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Changes in vowel articulation with subthalamic nucleus deep brain stimulation in dysarthric speakers with Parkinson's disease.

Martel Sauvageau V, Macoir J, Langlois M, Prud'Homme M, Cantin L, Roy JP - Parkinsons Dis (2014)

Bottom Line: Analyses also indicate that vowel articulation was modulated by the consonant context but this relationship did not change with STN DBS.Conclusions.Clinical considerations are discussed and new research avenues are suggested.

View Article: PubMed Central - PubMed

Affiliation: Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, Canada G1J 2G3.

ABSTRACT
Purpose. To investigate changes in vowel articulation with the electrical deep brain stimulation (DBS) of the subthalamic nucleus (STN) in dysarthric speakers with Parkinson's disease (PD). Methods. Eight Quebec-French speakers diagnosed with idiopathic PD who had undergone STN DBS were evaluated ON-stimulation and OFF-stimulation (1 hour after DBS was turned off). Vowel articulation was compared ON-simulation versus OFF-stimulation using acoustic vowel space and formant centralization ratio, calculated with the first (F1) and second formant (F2) of the vowels /i/, /u/, and /a/. The impact of the preceding consonant context on articulation, which represents a measure of coarticulation, was also analyzed as a function of the stimulation state. Results. Maximum vowel articulation increased during ON-stimulation. Analyses also indicate that vowel articulation was modulated by the consonant context but this relationship did not change with STN DBS. Conclusions. Results suggest that STN DBS may improve articulation in dysarthric speakers with PD, in terms of range of movement. Optimization of the electrical parameters for each patient is important and may lead to improvement in speech fine motor control. However, the impact on overall speech intelligibility may still be small. Clinical considerations are discussed and new research avenues are suggested.

No MeSH data available.


Related in: MedlinePlus

Acoustic vowel space values for vowels in labial, velar, and alveolar context in both stimulation conditions.
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Related In: Results  -  Collection


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fig2: Acoustic vowel space values for vowels in labial, velar, and alveolar context in both stimulation conditions.

Mentions: Figure 2 displays acoustic vowel space values (Hz2) calculated from F1 and F2 formant frequencies of the vowels /i/, /u/, and /a/ produced in labial, alveolar, and velar consonant contexts during OFF-stimulation and ON-stimulation. Statistical analyses for each context indicate a significant effect of the stimulation condition for each consonant context, with an increase in vowel articulation in the ON-stimulation condition: labial context: F(1; 6.8) = 19.71, P < 0.01; velar context: F(1; 6.9) = 13.46, P < 0.01; alveolar context: F(1; 7.0) = 32.31, P < 0.01. Furthermore, a mixed model ANOVA analysis was performed on data from all contexts with stimulation (OFF versus ON) and consonant context (labial versus alveolar versus velar) entered as fixed effects. A significant effect of the stimulation was found: F(1; 943.3) = 22.55, P < 0.000, with an increase in vowel articulation in the ON-stimulation condition. A significant effect of the consonant context was also found: F(2; 38.0) = 31.97, P < 0.000, where vowel articulation increased following the contexts: alveolar < velar < labial. On the other hand, no statistical interaction effect between the stimulation condition and consonant context was found: F(2; 38.0) = 0.621, P > 0.05. These results indicate that vowel articulation is influenced by the preceding consonant context but that this effect is not modulated by DBS, whether the stimulation is OFF or ON.


Changes in vowel articulation with subthalamic nucleus deep brain stimulation in dysarthric speakers with Parkinson's disease.

Martel Sauvageau V, Macoir J, Langlois M, Prud'Homme M, Cantin L, Roy JP - Parkinsons Dis (2014)

Acoustic vowel space values for vowels in labial, velar, and alveolar context in both stimulation conditions.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4221888&req=5

fig2: Acoustic vowel space values for vowels in labial, velar, and alveolar context in both stimulation conditions.
Mentions: Figure 2 displays acoustic vowel space values (Hz2) calculated from F1 and F2 formant frequencies of the vowels /i/, /u/, and /a/ produced in labial, alveolar, and velar consonant contexts during OFF-stimulation and ON-stimulation. Statistical analyses for each context indicate a significant effect of the stimulation condition for each consonant context, with an increase in vowel articulation in the ON-stimulation condition: labial context: F(1; 6.8) = 19.71, P < 0.01; velar context: F(1; 6.9) = 13.46, P < 0.01; alveolar context: F(1; 7.0) = 32.31, P < 0.01. Furthermore, a mixed model ANOVA analysis was performed on data from all contexts with stimulation (OFF versus ON) and consonant context (labial versus alveolar versus velar) entered as fixed effects. A significant effect of the stimulation was found: F(1; 943.3) = 22.55, P < 0.000, with an increase in vowel articulation in the ON-stimulation condition. A significant effect of the consonant context was also found: F(2; 38.0) = 31.97, P < 0.000, where vowel articulation increased following the contexts: alveolar < velar < labial. On the other hand, no statistical interaction effect between the stimulation condition and consonant context was found: F(2; 38.0) = 0.621, P > 0.05. These results indicate that vowel articulation is influenced by the preceding consonant context but that this effect is not modulated by DBS, whether the stimulation is OFF or ON.

Bottom Line: Analyses also indicate that vowel articulation was modulated by the consonant context but this relationship did not change with STN DBS.Conclusions.Clinical considerations are discussed and new research avenues are suggested.

View Article: PubMed Central - PubMed

Affiliation: Centre de Recherche, Institut Universitaire en Santé Mentale de Québec, Laboratoire Langage et Cognition, Québec, QC, Canada G1J 2G3.

ABSTRACT
Purpose. To investigate changes in vowel articulation with the electrical deep brain stimulation (DBS) of the subthalamic nucleus (STN) in dysarthric speakers with Parkinson's disease (PD). Methods. Eight Quebec-French speakers diagnosed with idiopathic PD who had undergone STN DBS were evaluated ON-stimulation and OFF-stimulation (1 hour after DBS was turned off). Vowel articulation was compared ON-simulation versus OFF-stimulation using acoustic vowel space and formant centralization ratio, calculated with the first (F1) and second formant (F2) of the vowels /i/, /u/, and /a/. The impact of the preceding consonant context on articulation, which represents a measure of coarticulation, was also analyzed as a function of the stimulation state. Results. Maximum vowel articulation increased during ON-stimulation. Analyses also indicate that vowel articulation was modulated by the consonant context but this relationship did not change with STN DBS. Conclusions. Results suggest that STN DBS may improve articulation in dysarthric speakers with PD, in terms of range of movement. Optimization of the electrical parameters for each patient is important and may lead to improvement in speech fine motor control. However, the impact on overall speech intelligibility may still be small. Clinical considerations are discussed and new research avenues are suggested.

No MeSH data available.


Related in: MedlinePlus