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A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.

Wang Y, Zha L, Liao D, Li X - Int J Genomics (2014)

Bottom Line: The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer.Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.

ABSTRACT
The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

No MeSH data available.


Related in: MedlinePlus

The flow diagram of the identification of studies.
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Related In: Results  -  Collection


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fig1: The flow diagram of the identification of studies.

Mentions: After a thorough scan of the databases, 68 eligible studies related to EGFR R521K polymorphism were identified. 30 of them were initially excluded by title or abstract; 25 of them were excluded due to case studies. As a consequence, 13 studies containing 7328 cases and 8455 controls were included in this meta-analysis (Figure 1). Among the 13 studies, 4 studies were related to breast cancer [12, 20, 22, 23], 3 studies were related to colorectal cancer [11, 18, 21], 2 studies each were related to gastric carcinoma and hepatocellular cancer [13, 14, 16, 17], and each related to lung cancer and thyroid cancer [15, 19]. The ethnicities of subjects in 3 studies were Arabs and Caucasian, respectively; 5 studies were Asian, 1 study was Mexican and Indian, respectively. Nine studies recruited controls based on population, 3 studies recruited controls with respect to gender and age of cases, and 1 study took subjects as controls in population based and matching-criteria based manner. The distributions of the R521K polymorphism genotype in all control groups of the studies were in accordance with HWE. Detailed characteristics of the selected studies were shown in Table 1.


A Meta-Analysis on the Relations between EGFR R521K Polymorphism and Risk of Cancer.

Wang Y, Zha L, Liao D, Li X - Int J Genomics (2014)

The flow diagram of the identification of studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4221867&req=5

fig1: The flow diagram of the identification of studies.
Mentions: After a thorough scan of the databases, 68 eligible studies related to EGFR R521K polymorphism were identified. 30 of them were initially excluded by title or abstract; 25 of them were excluded due to case studies. As a consequence, 13 studies containing 7328 cases and 8455 controls were included in this meta-analysis (Figure 1). Among the 13 studies, 4 studies were related to breast cancer [12, 20, 22, 23], 3 studies were related to colorectal cancer [11, 18, 21], 2 studies each were related to gastric carcinoma and hepatocellular cancer [13, 14, 16, 17], and each related to lung cancer and thyroid cancer [15, 19]. The ethnicities of subjects in 3 studies were Arabs and Caucasian, respectively; 5 studies were Asian, 1 study was Mexican and Indian, respectively. Nine studies recruited controls based on population, 3 studies recruited controls with respect to gender and age of cases, and 1 study took subjects as controls in population based and matching-criteria based manner. The distributions of the R521K polymorphism genotype in all control groups of the studies were in accordance with HWE. Detailed characteristics of the selected studies were shown in Table 1.

Bottom Line: The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer.Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

View Article: PubMed Central - PubMed

Affiliation: Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, China.

ABSTRACT
The EGFR R521K polymorphism has been shown to reduce the activity of EGFR; however, the association between EGFR R521K polymorphism and the risk of cancer remains inconclusive; therefore we performed a meta-analysis to evaluate the relationship between EGFR R521K polymorphism and susceptibility to cancer. Our results suggest that the EGFR R521K polymorphism is not associated with risk of cancer, but the different chemosensitivity to anticancer drugs may need further investigation.

No MeSH data available.


Related in: MedlinePlus