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Age-specific prevalence of hepatitis B virus infection in young pregnant women, Hong Kong Special Administrative Region of China.

Lao TT, Sahota DS, Law LW, Cheng YK, Leung TY - Bull. World Health Organ. (2014)

Bottom Line: Immunity to HBV in young pregnant women who had been vaccinated as neonates decreased in late adolescence.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing Street, Shatin, New Territories, Hong Kong Special Administrative Region, China .

ABSTRACT

Objective: To investigate the age-specific prevalence of hepatitis B virus (HBV) infection in young pregnant women in Hong Kong Special Administrative Region (SAR), China, and to determine whether an increase in prevalence occurs during adolescence.

Methods: HBV prevalence was quantified using data from routine antenatal screening for hepatitis B surface antigen (HBsAg) in 10 808 women aged 25 years or younger born in Hong Kong SAR and managed at a single hospital between 1998 and 2011. The effect on prevalence of maternal age, parity and birth before or after HBV vaccine availability in 1984 was assessed, using Spearman's correlation and multiple logistic regression analysis.

Findings: Overall, 7.5% of women were HBsAg-positive. The prevalence ranged from 2.3% to 8.4% in those aged ≤ 16 and 23 years, respectively. Women born in or after 1984 and those younger than 18 years of age were less likely to be HBsAg-positive (odds ratio, OR: 0.679; 95% confidence interval, CI: 0.578-0.797) and (OR: 0.311; 95% CI: 0.160-0.604), respectively. For women born before 1984, there was no association between HBsAg carriage and being younger than 18 years of age (OR: 0.60; 95% CI: 0.262-1.370) Logistic regression analysis showed that the prevalence of HBsAg carriage was influenced more by the woman being 18 years old or older (adjusted OR, aOR: 2.80; 95% CI: 1.46-5.47) than being born before 1984 (aOR: 1.42; 95% CI: 1.21-1.67).

Conclusion: Immunity to HBV in young pregnant women who had been vaccinated as neonates decreased in late adolescence.

No MeSH data available.


Related in: MedlinePlus

Prevalence of hepatitis B surface antigen carriage in young pregnant women, by age at parturition and year of birth, Hong Kong Special Administrative Region, China, 1998–2011
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Figure 1: Prevalence of hepatitis B surface antigen carriage in young pregnant women, by age at parturition and year of birth, Hong Kong Special Administrative Region, China, 1998–2011

Mentions: Of the 93 306 women who gave birth between 1998 and 2011 at our hospital, 10 808 (11.6%) were aged 25 years or younger. The overall prevalence of HBsAg carriage in these young women was 7.5%. As only 129 were aged 16 years or younger, they were grouped together for the analysis. The age-specific prevalence of HBsAg carriage is shown in Fig. 1. There was a significant difference between age groups (P = 0.020) and a positive correlation between age and prevalence (P = 0.006). The age-specific prevalence for women who were born before and in or after 1984 is also shown in Fig. 1 and in Table 1. For those born before 1984, there was no significant difference between age groups (P = 0.558) and no correlation between age and prevalence (P = 0.666). For those born in or after 1984, there was a significant difference between age groups (P = 0.018) and a significant positive correlation with age (P < 0.001).


Age-specific prevalence of hepatitis B virus infection in young pregnant women, Hong Kong Special Administrative Region of China.

Lao TT, Sahota DS, Law LW, Cheng YK, Leung TY - Bull. World Health Organ. (2014)

Prevalence of hepatitis B surface antigen carriage in young pregnant women, by age at parturition and year of birth, Hong Kong Special Administrative Region, China, 1998–2011
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221762&req=5

Figure 1: Prevalence of hepatitis B surface antigen carriage in young pregnant women, by age at parturition and year of birth, Hong Kong Special Administrative Region, China, 1998–2011
Mentions: Of the 93 306 women who gave birth between 1998 and 2011 at our hospital, 10 808 (11.6%) were aged 25 years or younger. The overall prevalence of HBsAg carriage in these young women was 7.5%. As only 129 were aged 16 years or younger, they were grouped together for the analysis. The age-specific prevalence of HBsAg carriage is shown in Fig. 1. There was a significant difference between age groups (P = 0.020) and a positive correlation between age and prevalence (P = 0.006). The age-specific prevalence for women who were born before and in or after 1984 is also shown in Fig. 1 and in Table 1. For those born before 1984, there was no significant difference between age groups (P = 0.558) and no correlation between age and prevalence (P = 0.666). For those born in or after 1984, there was a significant difference between age groups (P = 0.018) and a significant positive correlation with age (P < 0.001).

Bottom Line: Immunity to HBV in young pregnant women who had been vaccinated as neonates decreased in late adolescence.Abstract available from the publisher.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Ngan Shing Street, Shatin, New Territories, Hong Kong Special Administrative Region, China .

ABSTRACT

Objective: To investigate the age-specific prevalence of hepatitis B virus (HBV) infection in young pregnant women in Hong Kong Special Administrative Region (SAR), China, and to determine whether an increase in prevalence occurs during adolescence.

Methods: HBV prevalence was quantified using data from routine antenatal screening for hepatitis B surface antigen (HBsAg) in 10 808 women aged 25 years or younger born in Hong Kong SAR and managed at a single hospital between 1998 and 2011. The effect on prevalence of maternal age, parity and birth before or after HBV vaccine availability in 1984 was assessed, using Spearman's correlation and multiple logistic regression analysis.

Findings: Overall, 7.5% of women were HBsAg-positive. The prevalence ranged from 2.3% to 8.4% in those aged ≤ 16 and 23 years, respectively. Women born in or after 1984 and those younger than 18 years of age were less likely to be HBsAg-positive (odds ratio, OR: 0.679; 95% confidence interval, CI: 0.578-0.797) and (OR: 0.311; 95% CI: 0.160-0.604), respectively. For women born before 1984, there was no association between HBsAg carriage and being younger than 18 years of age (OR: 0.60; 95% CI: 0.262-1.370) Logistic regression analysis showed that the prevalence of HBsAg carriage was influenced more by the woman being 18 years old or older (adjusted OR, aOR: 2.80; 95% CI: 1.46-5.47) than being born before 1984 (aOR: 1.42; 95% CI: 1.21-1.67).

Conclusion: Immunity to HBV in young pregnant women who had been vaccinated as neonates decreased in late adolescence.

No MeSH data available.


Related in: MedlinePlus