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Functional neuroimaging abnormalities in idiopathic generalized epilepsy.

McGill ML, Devinsky O, Wang X, Quinn BT, Pardoe H, Carlson C, Butler T, Kuzniecky R, Thesen T - Neuroimage Clin (2014)

Bottom Line: There were no differences in FA values on DTI in tracts connecting the thalamus and prefrontal cortex.Functional analysis revealed decreased fALFF in the prefrontal cortex (PFC) subregion of the thalamus in patients with IGE.We provide minimum detectable effect sizes for each measure used in the study.

View Article: PubMed Central - PubMed

Affiliation: Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Magnetic resonance imaging (MRI) techniques have been used to quantitatively assess focal and network abnormalities. Idiopathic generalized epilepsy (IGE) is characterized by bilateral synchronous spike-wave discharges on electroencephalography (EEG) but normal clinical MRI. Dysfunctions involving the neocortex, particularly the prefrontal cortex, and thalamus likely contribute to seizure activity. To identify possible morphometric and functional differences in the brains of IGE patients and normal controls, we employed measures of thalamic volumes, cortical thickness, gray-white blurring, fractional anisotropy (FA) measures from diffusion tensor imaging (DTI) and fractional amplitude of low frequency fluctuations (fALFF) in thalamic subregions from resting state functional MRI. Data from 27 patients with IGE and 27 age- and sex-matched controls showed similar thalamic volumes, cortical thickness and gray-white contrast. There were no differences in FA values on DTI in tracts connecting the thalamus and prefrontal cortex. Functional analysis revealed decreased fALFF in the prefrontal cortex (PFC) subregion of the thalamus in patients with IGE. We provide minimum detectable effect sizes for each measure used in the study. Our analysis indicates that fMRI-based methods are more sensitive than quantitative structural techniques for characterizing brain abnormalities in IGE.

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Related in: MedlinePlus

Box plots of the right and the left thalamus show volumes in IGE subjects and normal controls. There are no significant volumetric differences between the two study groups.
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f0010: Box plots of the right and the left thalamus show volumes in IGE subjects and normal controls. There are no significant volumetric differences between the two study groups.

Mentions: Thalamic volume did not differ between patients with IGE and controls. Left thalamic volumes for those with IGE and normal controls were 6940 and 6744 mm3, respectively (p = .299). Right thalamic volumes for IGE and normal controls were 6982 and 7027 mm3, respectively (p = .814). ICV was a predictor of both left and right thalamic volumes (p < 0.001), but a history of epilepsy was not predictive of left thalamus volume (p = 0.599) or right thalamus volume (p = 0.232). Fig. 2 depicts the distribution of thalamic volumes in patients with IGE and normal controls.


Functional neuroimaging abnormalities in idiopathic generalized epilepsy.

McGill ML, Devinsky O, Wang X, Quinn BT, Pardoe H, Carlson C, Butler T, Kuzniecky R, Thesen T - Neuroimage Clin (2014)

Box plots of the right and the left thalamus show volumes in IGE subjects and normal controls. There are no significant volumetric differences between the two study groups.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221627&req=5

f0010: Box plots of the right and the left thalamus show volumes in IGE subjects and normal controls. There are no significant volumetric differences between the two study groups.
Mentions: Thalamic volume did not differ between patients with IGE and controls. Left thalamic volumes for those with IGE and normal controls were 6940 and 6744 mm3, respectively (p = .299). Right thalamic volumes for IGE and normal controls were 6982 and 7027 mm3, respectively (p = .814). ICV was a predictor of both left and right thalamic volumes (p < 0.001), but a history of epilepsy was not predictive of left thalamus volume (p = 0.599) or right thalamus volume (p = 0.232). Fig. 2 depicts the distribution of thalamic volumes in patients with IGE and normal controls.

Bottom Line: There were no differences in FA values on DTI in tracts connecting the thalamus and prefrontal cortex.Functional analysis revealed decreased fALFF in the prefrontal cortex (PFC) subregion of the thalamus in patients with IGE.We provide minimum detectable effect sizes for each measure used in the study.

View Article: PubMed Central - PubMed

Affiliation: Comprehensive Epilepsy Center, Department of Neurology, New York University School of Medicine, New York, NY 10016, USA.

ABSTRACT
Magnetic resonance imaging (MRI) techniques have been used to quantitatively assess focal and network abnormalities. Idiopathic generalized epilepsy (IGE) is characterized by bilateral synchronous spike-wave discharges on electroencephalography (EEG) but normal clinical MRI. Dysfunctions involving the neocortex, particularly the prefrontal cortex, and thalamus likely contribute to seizure activity. To identify possible morphometric and functional differences in the brains of IGE patients and normal controls, we employed measures of thalamic volumes, cortical thickness, gray-white blurring, fractional anisotropy (FA) measures from diffusion tensor imaging (DTI) and fractional amplitude of low frequency fluctuations (fALFF) in thalamic subregions from resting state functional MRI. Data from 27 patients with IGE and 27 age- and sex-matched controls showed similar thalamic volumes, cortical thickness and gray-white contrast. There were no differences in FA values on DTI in tracts connecting the thalamus and prefrontal cortex. Functional analysis revealed decreased fALFF in the prefrontal cortex (PFC) subregion of the thalamus in patients with IGE. We provide minimum detectable effect sizes for each measure used in the study. Our analysis indicates that fMRI-based methods are more sensitive than quantitative structural techniques for characterizing brain abnormalities in IGE.

Show MeSH
Related in: MedlinePlus