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Vitamin d in the general population of young adults with autism in the faroe islands.

Kočovská E, Andorsdóttir G, Weihe P, Halling J, Fernell E, Stóra T, Biskupstø R, Gillberg IC, Shea R, Billstedt E, Bourgeron T, Minnis H, Gillberg C - J Autism Dev Disord (2014)

Bottom Line: The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons.There was a trend for males having lower 25(OH)D3 than females.The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.

View Article: PubMed Central - PubMed

Affiliation: Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Kungsgatan 12, 411 19, Göteborg, Sweden, eva.kocovska@gnc.gu.se.

ABSTRACT
Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.

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25(OH)D3 status among ASD and comparison groups (95 % CI, p = 0.003)
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Fig2: 25(OH)D3 status among ASD and comparison groups (95 % CI, p = 0.003)

Mentions: In the ASD group, 88 % were vitamin D deficient (Fig. 2). Among their siblings, parents, and the comparison group, the corresponding rates were 58, 58, and 65 % respectively (p < 0.001) (Table 1): for clarity and comparability of our results with several recently published studies of vitamin D levels in patients with autism we resolved to use the same reference ranges as (Holick et al. 2011) and we used values of nmol per litre (nmol/L).Fig. 2


Vitamin d in the general population of young adults with autism in the faroe islands.

Kočovská E, Andorsdóttir G, Weihe P, Halling J, Fernell E, Stóra T, Biskupstø R, Gillberg IC, Shea R, Billstedt E, Bourgeron T, Minnis H, Gillberg C - J Autism Dev Disord (2014)

25(OH)D3 status among ASD and comparison groups (95 % CI, p = 0.003)
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4221602&req=5

Fig2: 25(OH)D3 status among ASD and comparison groups (95 % CI, p = 0.003)
Mentions: In the ASD group, 88 % were vitamin D deficient (Fig. 2). Among their siblings, parents, and the comparison group, the corresponding rates were 58, 58, and 65 % respectively (p < 0.001) (Table 1): for clarity and comparability of our results with several recently published studies of vitamin D levels in patients with autism we resolved to use the same reference ranges as (Holick et al. 2011) and we used values of nmol per litre (nmol/L).Fig. 2

Bottom Line: The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons.There was a trend for males having lower 25(OH)D3 than females.The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.

View Article: PubMed Central - PubMed

Affiliation: Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Kungsgatan 12, 411 19, Göteborg, Sweden, eva.kocovska@gnc.gu.se.

ABSTRACT
Vitamin D deficiency has been proposed as a possible risk factor for developing autism spectrum disorder (ASD). 25-Hydroxyvitamin D3 (25(OH)D3) levels were examined in a cross-sectional population-based study in the Faroe Islands. The case group consisting of a total population cohort of 40 individuals with ASD (aged 15-24 years) had significantly lower 25(OH)D3 than their 62 typically-developing siblings and their 77 parents, and also significantly lower than 40 healthy age and gender matched comparisons. There was a trend for males having lower 25(OH)D3 than females. Effects of age, month/season of birth, IQ, various subcategories of ASD and Autism Diagnostic Observation Schedule score were also investigated, however, no association was found. The very low 25(OH)D3 in the ASD group suggests some underlying pathogenic mechanism.

Show MeSH
Related in: MedlinePlus