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Confluent and reticulated papillomatosis manifested as vertically rippled and keratotic plaques.

Min ZS, Tan C, Xu P, Zhu WY - Postepy Dermatol Alergol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, First Affiliated Hospital of Nan Jing University of Traditional Chinese Medicine, Jiang Su Province, Nan Jing, China. Head of Department: Prof. Zhong-Sheng Min.

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Confluent and reticulated papillomatosis (CRP) is a rare dermatosis of uncertain etiology that preferentially affects young adults... Eruptions usually present as grayish brown, flat elevated, keratotic papules and plaques that are confluent centrally and reticulated peripherally... We reported a young boy of CRP manifesting vertically rippled and keratotic streaks on his trunk... Amyloid deposition was not identified with Congo red stain... The results of the laboratory evaluation and chemistry profile were within normal limits, and no endocrine imbalance including diabetes mellitus was detected... A acid-Schiff stain is predicted to be negative... Electron microscopic study revealed that increased melanin pigmentation in CRP is resulted from increased melanosomes present in the hyperkeratotic horny layer... The differential diagnosis for our patient was wide and included acanthosis nigricans, Prurigo pigmentosa, Darier's disease, tinea versicolor and amyloidosis etc.... Acanthosis nigricans was not favored due to lack of histologic evidence of papillomatosis resulting from the upward projection of finger-like dermal papillae which are covered by thinned epidermis... The etiology and pathogenesis of CRP are not precisely known... Confluent and reticulated papillomatosis can be recalcitrant to present therapies, including salicylic acid, topical or systemic steroids, vitamin D3 analogues, vitamin A derivatives, selenium sulfide, liquid nitrogen, progesterone, coal tar, dermabrasion, hydroquinone, phototherapy, 5-fluorouracil, thyroid extracts, anti-fungal agents, and antibiotics such as minocycline... However, we observed a marked improvement with the administration of isotretinoin for a period of 5 months... Confluent and reticulated papillomatosis might present with rippled keratotic streaks, and every dermatologist should be aware of such rare demonstrations.

No MeSH data available.


The lesions were brownish-black keratotic streaks that rippled vertically
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Figure 0002: The lesions were brownish-black keratotic streaks that rippled vertically

Mentions: An 18-year-old boy was admitted to our dermatology department with vertically rippled and keratotic eruptions on the trunk. Two years ago, the patient noticed light brown and rippled streaks on his epigastric area. It became abruptly spreading on the chest, the back and waist during recent 6 months. There were no itching or other complaints. His past medical history was noncontributory. At the time of our observation, his height and weight were 170 cm and 89 kg, respectively, with a body mass index equal to 30.8 kg/m2 (normal value < 25 kg/m2). Cutaneous examination showed brownish-black, vertically rippled and keratotic streaks involving his abdomen and the waist. In addition, red papules and plaques were seen around the axilla and antecubital fossae (Figures 1 and 2). An unstained specimen and culture of fine scale obtained from skin scrapings was negative. No fluorescence was observed in the affected skin under a Wood light examination. The biopsy specimens taken from the epigastric region revealed slight basket-weave hyperkeratosis, squat papillomatosis and a slight perivascular mononuclear infiltration in the upper dermis (Figure 3). Amyloid deposition was not identified with Congo red stain. The results of the laboratory evaluation and chemistry profile were within normal limits, and no endocrine imbalance including diabetes mellitus was detected.


Confluent and reticulated papillomatosis manifested as vertically rippled and keratotic plaques.

Min ZS, Tan C, Xu P, Zhu WY - Postepy Dermatol Alergol (2014)

The lesions were brownish-black keratotic streaks that rippled vertically
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221353&req=5

Figure 0002: The lesions were brownish-black keratotic streaks that rippled vertically
Mentions: An 18-year-old boy was admitted to our dermatology department with vertically rippled and keratotic eruptions on the trunk. Two years ago, the patient noticed light brown and rippled streaks on his epigastric area. It became abruptly spreading on the chest, the back and waist during recent 6 months. There were no itching or other complaints. His past medical history was noncontributory. At the time of our observation, his height and weight were 170 cm and 89 kg, respectively, with a body mass index equal to 30.8 kg/m2 (normal value < 25 kg/m2). Cutaneous examination showed brownish-black, vertically rippled and keratotic streaks involving his abdomen and the waist. In addition, red papules and plaques were seen around the axilla and antecubital fossae (Figures 1 and 2). An unstained specimen and culture of fine scale obtained from skin scrapings was negative. No fluorescence was observed in the affected skin under a Wood light examination. The biopsy specimens taken from the epigastric region revealed slight basket-weave hyperkeratosis, squat papillomatosis and a slight perivascular mononuclear infiltration in the upper dermis (Figure 3). Amyloid deposition was not identified with Congo red stain. The results of the laboratory evaluation and chemistry profile were within normal limits, and no endocrine imbalance including diabetes mellitus was detected.

View Article: PubMed Central - PubMed

Affiliation: Department of Dermatology, First Affiliated Hospital of Nan Jing University of Traditional Chinese Medicine, Jiang Su Province, Nan Jing, China. Head of Department: Prof. Zhong-Sheng Min.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Confluent and reticulated papillomatosis (CRP) is a rare dermatosis of uncertain etiology that preferentially affects young adults... Eruptions usually present as grayish brown, flat elevated, keratotic papules and plaques that are confluent centrally and reticulated peripherally... We reported a young boy of CRP manifesting vertically rippled and keratotic streaks on his trunk... Amyloid deposition was not identified with Congo red stain... The results of the laboratory evaluation and chemistry profile were within normal limits, and no endocrine imbalance including diabetes mellitus was detected... A acid-Schiff stain is predicted to be negative... Electron microscopic study revealed that increased melanin pigmentation in CRP is resulted from increased melanosomes present in the hyperkeratotic horny layer... The differential diagnosis for our patient was wide and included acanthosis nigricans, Prurigo pigmentosa, Darier's disease, tinea versicolor and amyloidosis etc.... Acanthosis nigricans was not favored due to lack of histologic evidence of papillomatosis resulting from the upward projection of finger-like dermal papillae which are covered by thinned epidermis... The etiology and pathogenesis of CRP are not precisely known... Confluent and reticulated papillomatosis can be recalcitrant to present therapies, including salicylic acid, topical or systemic steroids, vitamin D3 analogues, vitamin A derivatives, selenium sulfide, liquid nitrogen, progesterone, coal tar, dermabrasion, hydroquinone, phototherapy, 5-fluorouracil, thyroid extracts, anti-fungal agents, and antibiotics such as minocycline... However, we observed a marked improvement with the administration of isotretinoin for a period of 5 months... Confluent and reticulated papillomatosis might present with rippled keratotic streaks, and every dermatologist should be aware of such rare demonstrations.

No MeSH data available.