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Multimodal retinal vessel analysis in CADASIL patients.

Alten F, Motte J, Ewering C, Osada N, Clemens CR, Kadas EM, Eter N, Paul F, Marziniak M - PLoS ONE (2014)

Bottom Line: RNFL measurements showed a global increase of 105.2 µm ( 98.4 µm; p = 0.015).Based on semi-automatic cSLO measurements, maximum diameters of arteries and veins were 102.5 µm (106.0 µm; p = 0.21) and 128.6 µm (124.4 µm; p = 0.27) respectively.SD-OCT may serve as a complementary tool to diagnose and follow-up patients suffering from cerebral small-vessel diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.

ABSTRACT

Purpose: To further elucidate retinal findings and retinal vessel changes in Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients by means of high resolution retinal imaging.

Methods: 28 eyes of fourteen CADASIL patients and an equal number of control subjects underwent confocal scanning laser ophthalmoscopy (cSLO), spectral-domain optical coherence tomography (SD-OCT), retinal nerve fibre layer (RNFL) measurements, fluorescein and indocyanine angiography. Three vessel measurement techniques were applied: RNFL thickness, a semiautomatic software tool based on cSLO images and manual vessel outlining based on SD-OCT.

Results: Mean age of patients was 56.2 ± 11.6 years. Arteriovenous nicking was present in 22 (78.6%) eyes and venous dilation in 24 (85.7%) eyes. Retinal volume and choroidal volume were 8.77 ± 0.46 mm(3) and 8.83 ± 2.24 mm(3). RNFL measurements showed a global increase of 105.2 µm (

Control group: 98.4 µm; p = 0.015). Based on semi-automatic cSLO measurements, maximum diameters of arteries and veins were 102.5 µm (106.0 µm; p = 0.21) and 128.6 µm (124.4 µm; p = 0.27) respectively. Manual SD-OCT measurements revealed significantly increased mean arterial 138.7 µm (125.4 µm; p<0.001) and venous 160.0 µm (146.9; p = 0.003) outer diameters as well as mean arterial 27.4 µm (19.2 µm; p<0.001) and venous 18.3 µm (15.7 µm; p<0.001) wall thicknesses in CADASIL patients.

Conclusions: The findings reflect current knowledge on pathophysiologic changes in vessel morphology in CADASIL patients. SD-OCT may serve as a complementary tool to diagnose and follow-up patients suffering from cerebral small-vessel diseases.

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A–D Measurement of retinal nerve fiber layer (RNFL) thickness, using a circular B-scan placed around the optic disc.A Confocal scanning laser ophthalmoscopy infrared image shows optic disc with circular scan (diameter: 3.5 mm). B Corresponding spectral domain optical coherence tomography scan. Red marks delineate automatically borders of RNFL layer. C Presentation of RNFL thickness values for individual sectors and global measurement. D Individual measurement graphically compared to a healthy population.
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pone-0112311-g001: A–D Measurement of retinal nerve fiber layer (RNFL) thickness, using a circular B-scan placed around the optic disc.A Confocal scanning laser ophthalmoscopy infrared image shows optic disc with circular scan (diameter: 3.5 mm). B Corresponding spectral domain optical coherence tomography scan. Red marks delineate automatically borders of RNFL layer. C Presentation of RNFL thickness values for individual sectors and global measurement. D Individual measurement graphically compared to a healthy population.

Mentions: Measurement of retinal nerve fiber layer (RNFL) thickness was performed using a circular B-scan placed around the optic disc (diameter: 3.5 mm) [24]. The exactly located placement around the center of the optic disc was carefully reviewed. Sectorial analysis of mean RNFL thickness is illustrated in Figure 1.


Multimodal retinal vessel analysis in CADASIL patients.

Alten F, Motte J, Ewering C, Osada N, Clemens CR, Kadas EM, Eter N, Paul F, Marziniak M - PLoS ONE (2014)

A–D Measurement of retinal nerve fiber layer (RNFL) thickness, using a circular B-scan placed around the optic disc.A Confocal scanning laser ophthalmoscopy infrared image shows optic disc with circular scan (diameter: 3.5 mm). B Corresponding spectral domain optical coherence tomography scan. Red marks delineate automatically borders of RNFL layer. C Presentation of RNFL thickness values for individual sectors and global measurement. D Individual measurement graphically compared to a healthy population.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221286&req=5

pone-0112311-g001: A–D Measurement of retinal nerve fiber layer (RNFL) thickness, using a circular B-scan placed around the optic disc.A Confocal scanning laser ophthalmoscopy infrared image shows optic disc with circular scan (diameter: 3.5 mm). B Corresponding spectral domain optical coherence tomography scan. Red marks delineate automatically borders of RNFL layer. C Presentation of RNFL thickness values for individual sectors and global measurement. D Individual measurement graphically compared to a healthy population.
Mentions: Measurement of retinal nerve fiber layer (RNFL) thickness was performed using a circular B-scan placed around the optic disc (diameter: 3.5 mm) [24]. The exactly located placement around the center of the optic disc was carefully reviewed. Sectorial analysis of mean RNFL thickness is illustrated in Figure 1.

Bottom Line: RNFL measurements showed a global increase of 105.2 µm ( 98.4 µm; p = 0.015).Based on semi-automatic cSLO measurements, maximum diameters of arteries and veins were 102.5 µm (106.0 µm; p = 0.21) and 128.6 µm (124.4 µm; p = 0.27) respectively.SD-OCT may serve as a complementary tool to diagnose and follow-up patients suffering from cerebral small-vessel diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.

ABSTRACT

Purpose: To further elucidate retinal findings and retinal vessel changes in Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients by means of high resolution retinal imaging.

Methods: 28 eyes of fourteen CADASIL patients and an equal number of control subjects underwent confocal scanning laser ophthalmoscopy (cSLO), spectral-domain optical coherence tomography (SD-OCT), retinal nerve fibre layer (RNFL) measurements, fluorescein and indocyanine angiography. Three vessel measurement techniques were applied: RNFL thickness, a semiautomatic software tool based on cSLO images and manual vessel outlining based on SD-OCT.

Results: Mean age of patients was 56.2 ± 11.6 years. Arteriovenous nicking was present in 22 (78.6%) eyes and venous dilation in 24 (85.7%) eyes. Retinal volume and choroidal volume were 8.77 ± 0.46 mm(3) and 8.83 ± 2.24 mm(3). RNFL measurements showed a global increase of 105.2 µm (

Control group: 98.4 µm; p = 0.015). Based on semi-automatic cSLO measurements, maximum diameters of arteries and veins were 102.5 µm (106.0 µm; p = 0.21) and 128.6 µm (124.4 µm; p = 0.27) respectively. Manual SD-OCT measurements revealed significantly increased mean arterial 138.7 µm (125.4 µm; p<0.001) and venous 160.0 µm (146.9; p = 0.003) outer diameters as well as mean arterial 27.4 µm (19.2 µm; p<0.001) and venous 18.3 µm (15.7 µm; p<0.001) wall thicknesses in CADASIL patients.

Conclusions: The findings reflect current knowledge on pathophysiologic changes in vessel morphology in CADASIL patients. SD-OCT may serve as a complementary tool to diagnose and follow-up patients suffering from cerebral small-vessel diseases.

Show MeSH
Related in: MedlinePlus