Limits...
A rare case of hepatic T-cell rich B-cell lymphoma (TCRBCL) in a juvenile dog.

Chung TH, Lamm C, Choi YC, Lee JW, Yu D, Choi US - J. Vet. Med. Sci. (2014)

Bottom Line: The cytologic impression was hepatic lymphoma, which was later confirmed by histopathology.Therefore, the immunohistochemical results were definitively consistent with a T-cell rich B-cell lymphoma (TCRBCL).This is the first description of a hepatic TCRBCL in a juvenile dog showing a poor response to aggressive chemotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, Joongbu University, Gumsan-gun, Chungnam 312-702, South Korea.

ABSTRACT
A 7-month-old castrated male French Bull dog was presented with vomiting, lethargy, anorexia and weight loss of 2 weeks duration. The patient's history and clinical manifestations of suspected hepatopathy were subjected to ultrasonography, radiography, biochemical investigations and cytology of hepatic lesion. The cytologic impression was hepatic lymphoma, which was later confirmed by histopathology. The neoplastic cells were strongly diffusely immunoreactive for PAX5, but not immunoreactive for CD3, and B lymphocyte specific clonal proliferation was detected using by assay of antigen receptor rearrangement. Large numbers of immunoreactive mature non-neoplastic lymphocytes were admixed with the neoplastic cell population. Therefore, the immunohistochemical results were definitively consistent with a T-cell rich B-cell lymphoma (TCRBCL). This is the first description of a hepatic TCRBCL in a juvenile dog showing a poor response to aggressive chemotherapy.

Show MeSH

Related in: MedlinePlus

On abdominal radiograph, there is extremely hepatomegaly with blunt margination andcaudal deviation of gastric axis. There is poor detail in the peritoneal space, and theanimal is in thin body condition (a). Uniformly increased hepatic parenchymalechogenicity, reduced visualization of portal structures and small amount of ascites aredescribed. There is extension of the liver ventral to the stomach, and liver is slightlyhigher echo intensity than the spleen (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4221174&req=5

fig_001: On abdominal radiograph, there is extremely hepatomegaly with blunt margination andcaudal deviation of gastric axis. There is poor detail in the peritoneal space, and theanimal is in thin body condition (a). Uniformly increased hepatic parenchymalechogenicity, reduced visualization of portal structures and small amount of ascites aredescribed. There is extension of the liver ventral to the stomach, and liver is slightlyhigher echo intensity than the spleen (b).

Mentions: A 7-month-old castrated male French Bull dog presented with vomiting, lethargy, anorexia andweight loss of 2 weeks duration. A complete blood count was within normal physiologicalreference ranges, except for mild anemia without polychromasia in the blood smear (red bloodcells, 4.95 × 106/µl; reference range, 5.50–8.50 ×106/µl). Serum biochemistry revealed mildly decreasedelectrolytes and increased liver enzyme activity, which were consistent with hepaticinsufficiency. Survey radiography identified severe hepatomegaly, blunted liver margin andserosal detail loss. On ultrasonographic examination, hepatic echogenicity was homogenouslyincreased compared with splenic and renal echogenicities, and there were no findings of focalabnormalities. However, it was difficult to make comparison with echogenicity between spleenand liver, and spleen was enlarged and hypoechoic (Fig. 1aand 1bFig. 1.


A rare case of hepatic T-cell rich B-cell lymphoma (TCRBCL) in a juvenile dog.

Chung TH, Lamm C, Choi YC, Lee JW, Yu D, Choi US - J. Vet. Med. Sci. (2014)

On abdominal radiograph, there is extremely hepatomegaly with blunt margination andcaudal deviation of gastric axis. There is poor detail in the peritoneal space, and theanimal is in thin body condition (a). Uniformly increased hepatic parenchymalechogenicity, reduced visualization of portal structures and small amount of ascites aredescribed. There is extension of the liver ventral to the stomach, and liver is slightlyhigher echo intensity than the spleen (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4221174&req=5

fig_001: On abdominal radiograph, there is extremely hepatomegaly with blunt margination andcaudal deviation of gastric axis. There is poor detail in the peritoneal space, and theanimal is in thin body condition (a). Uniformly increased hepatic parenchymalechogenicity, reduced visualization of portal structures and small amount of ascites aredescribed. There is extension of the liver ventral to the stomach, and liver is slightlyhigher echo intensity than the spleen (b).
Mentions: A 7-month-old castrated male French Bull dog presented with vomiting, lethargy, anorexia andweight loss of 2 weeks duration. A complete blood count was within normal physiologicalreference ranges, except for mild anemia without polychromasia in the blood smear (red bloodcells, 4.95 × 106/µl; reference range, 5.50–8.50 ×106/µl). Serum biochemistry revealed mildly decreasedelectrolytes and increased liver enzyme activity, which were consistent with hepaticinsufficiency. Survey radiography identified severe hepatomegaly, blunted liver margin andserosal detail loss. On ultrasonographic examination, hepatic echogenicity was homogenouslyincreased compared with splenic and renal echogenicities, and there were no findings of focalabnormalities. However, it was difficult to make comparison with echogenicity between spleenand liver, and spleen was enlarged and hypoechoic (Fig. 1aand 1bFig. 1.

Bottom Line: The cytologic impression was hepatic lymphoma, which was later confirmed by histopathology.Therefore, the immunohistochemical results were definitively consistent with a T-cell rich B-cell lymphoma (TCRBCL).This is the first description of a hepatic TCRBCL in a juvenile dog showing a poor response to aggressive chemotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Animal Science, Joongbu University, Gumsan-gun, Chungnam 312-702, South Korea.

ABSTRACT
A 7-month-old castrated male French Bull dog was presented with vomiting, lethargy, anorexia and weight loss of 2 weeks duration. The patient's history and clinical manifestations of suspected hepatopathy were subjected to ultrasonography, radiography, biochemical investigations and cytology of hepatic lesion. The cytologic impression was hepatic lymphoma, which was later confirmed by histopathology. The neoplastic cells were strongly diffusely immunoreactive for PAX5, but not immunoreactive for CD3, and B lymphocyte specific clonal proliferation was detected using by assay of antigen receptor rearrangement. Large numbers of immunoreactive mature non-neoplastic lymphocytes were admixed with the neoplastic cell population. Therefore, the immunohistochemical results were definitively consistent with a T-cell rich B-cell lymphoma (TCRBCL). This is the first description of a hepatic TCRBCL in a juvenile dog showing a poor response to aggressive chemotherapy.

Show MeSH
Related in: MedlinePlus