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Extra-axial medulloblastoma in cerebello-pontine angle: A report of a rare case with literature review.

Bahrami E, Bakhti S, Fereshtehnejad SM, Parvaresh M, Khani MR - Med J Islam Repub Iran (2014)

Bottom Line: In this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented.Clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right CP angle.After surgery, the patient had no neurological deficit and the audiometric findings were improved.

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Affiliation: 1. Department of Neurosurgery, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. bahrami_eses@yahoo.com.

ABSTRACT
Medulloblastoma is quite uncommon in the adult population and even rarer in extra-axial site in cerebello-pontine (CP) angle. In this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented. Clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right CP angle. Total excision was performed and the histopathological features of medulloblastoma were confirmed. After surgery, the patient had no neurological deficit and the audiometric findings were improved. In addition, he underwent adjuant radiotherapy and no sign of metastatic mass was observed in follow-up spinal cord MRI. Although extremely rare, medulloblastoma must be considered in the differential diagnosis of extra-axial CP angle lesions.

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Mentions: He underwent right retromastoid craniectomy and gross total excision of the lesion with facial nerve monitoring. There was a clear plane between the tumor and cerebellum, whereas it was adherent to tent laterally. Histopathologic evaluation showed “pale islands” consisting of micronodular, reticulin-free zones with a low magnification appearance similar to follicular lymphoid hyperplasia. The lesion was characterized by reduced cellularity, a rarefied fibrillar matrix and compact undifferentiated area (Fig. 3). After surgery, the patient had no neurological deficit and his audiometric findings were improved. The postoperative MRI showed total extirpation of the tumor (Fi. 4-A). In addition, he underwent radiotherapy as adjuvant treatment. The latest follow-up was performed one-year post-operation by means of brain MRI, which shows no lesion in the right CP angle (Fig. 4-B).


Extra-axial medulloblastoma in cerebello-pontine angle: A report of a rare case with literature review.

Bahrami E, Bakhti S, Fereshtehnejad SM, Parvaresh M, Khani MR - Med J Islam Repub Iran (2014)

© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219907&req=5

Mentions: He underwent right retromastoid craniectomy and gross total excision of the lesion with facial nerve monitoring. There was a clear plane between the tumor and cerebellum, whereas it was adherent to tent laterally. Histopathologic evaluation showed “pale islands” consisting of micronodular, reticulin-free zones with a low magnification appearance similar to follicular lymphoid hyperplasia. The lesion was characterized by reduced cellularity, a rarefied fibrillar matrix and compact undifferentiated area (Fig. 3). After surgery, the patient had no neurological deficit and his audiometric findings were improved. The postoperative MRI showed total extirpation of the tumor (Fi. 4-A). In addition, he underwent radiotherapy as adjuvant treatment. The latest follow-up was performed one-year post-operation by means of brain MRI, which shows no lesion in the right CP angle (Fig. 4-B).

Bottom Line: In this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented.Clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right CP angle.After surgery, the patient had no neurological deficit and the audiometric findings were improved.

View Article: PubMed Central - HTML - PubMed

Affiliation: 1. Department of Neurosurgery, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. bahrami_eses@yahoo.com.

ABSTRACT
Medulloblastoma is quite uncommon in the adult population and even rarer in extra-axial site in cerebello-pontine (CP) angle. In this report, a 23-year-old male patient with a two month history of deafness, nausea, vomiting and ataxia is presented. Clinical and radiological findings demonstrated a heterogeneously enhanced extra-axial lesion in the right CP angle. Total excision was performed and the histopathological features of medulloblastoma were confirmed. After surgery, the patient had no neurological deficit and the audiometric findings were improved. In addition, he underwent adjuant radiotherapy and no sign of metastatic mass was observed in follow-up spinal cord MRI. Although extremely rare, medulloblastoma must be considered in the differential diagnosis of extra-axial CP angle lesions.

No MeSH data available.


Related in: MedlinePlus