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Trajectories of metabolic syndrome development in young adults.

Poon VT, Kuk JL, Ardern CI - PLoS ONE (2014)

Bottom Line: Data from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3 804; 18-30 y) was obtained by limited access application from the National Heart, Lung, and Blood Institute and used for this analysis.After adjusting for covariates, individuals in the At-Risk groups (Low, Moderate and High MetS) were more likely to be of black ethnicity (1.37, 1.14-1.66), have a family history of cardiovascular disease (1.61, 1.31-1.97) and history of dieting (1.69, 1.20-2.39) when compared to the No Risk trajectory group (No MetS).Conversely, increasing baseline education (0.76, 0.65-0.89) and aerobic fitness (0.55, 0.47-0.64) was inversely associated with At-Risk group membership.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada.

ABSTRACT

Background: Metabolic syndrome (MetS) is a constellation of metabolic aberrations that collectively increase the risk for cardiovascular disease and type 2 diabetes. Greater understanding of MetS developments may provide insight into targeted prevention strategies for individuals at greatest risk. The purpose of this study was to i) identify distinct patterns of longitudinal MetS development and; ii) develop a character profile that differentiates groups by level of MetS risk.

Methods and results: Data from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3 804; 18-30 y) was obtained by limited access application from the National Heart, Lung, and Blood Institute and used for this analysis. MetS, as defined by the Harmonized criteria, was assessed over a 20 year follow-up period. Group-level trajectory analysis identified 4 distinct groups with varying rates of component development [No (23.8% of sample); Low (33.5%); Moderate (35.3%); and High MetS (7.4%)]. After adjusting for covariates, individuals in the At-Risk groups (Low, Moderate and High MetS) were more likely to be of black ethnicity (1.37, 1.14-1.66), have a family history of cardiovascular disease (1.61, 1.31-1.97) and history of dieting (1.69, 1.20-2.39) when compared to the No Risk trajectory group (No MetS). Conversely, increasing baseline education (0.76, 0.65-0.89) and aerobic fitness (0.55, 0.47-0.64) was inversely associated with At-Risk group membership.

Conclusions: Results suggest distinct profiles of MetS development that can be identified by baseline risk factors. Further research is necessary to understand the clinical implication of intermediate MetS development groups with respect to overall cardiometabolic risk.

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Related in: MedlinePlus

Ethnic-gender specific group-based trajectory of MetS development probability over a 20-year span as determined by PROC TRAJ censored normal modelling in 3 804 apparently healthy young adults.Figure 3A depicts four distinct trajectories among Black females (n = 1 077). Figure 3B depicts two distinct trajectories among White females (n = 1 033). Figure 3C depicts three distinct trajectories among Black males (n = 794). Figure 3D depicts three distinct trajectories among Black males (n = 900).
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pone-0111647-g003: Ethnic-gender specific group-based trajectory of MetS development probability over a 20-year span as determined by PROC TRAJ censored normal modelling in 3 804 apparently healthy young adults.Figure 3A depicts four distinct trajectories among Black females (n = 1 077). Figure 3B depicts two distinct trajectories among White females (n = 1 033). Figure 3C depicts three distinct trajectories among Black males (n = 794). Figure 3D depicts three distinct trajectories among Black males (n = 900).

Mentions: Potential gender and ethnic differences within the cohort were also assessed, and gender- and ethnic-specific models were developed (Figure 3). Analyses yielded four distinct trajectories among black women, and two groups among white women. Amongst male participants, both black and white cohorts presented similar trajectory plots with three distinct groups each. Due to sample size constraints, extensive post-hoc analyses could not be conducted, meaning that predictive modeling was limited to the overall pooled trajectories (Figure 2).


Trajectories of metabolic syndrome development in young adults.

Poon VT, Kuk JL, Ardern CI - PLoS ONE (2014)

Ethnic-gender specific group-based trajectory of MetS development probability over a 20-year span as determined by PROC TRAJ censored normal modelling in 3 804 apparently healthy young adults.Figure 3A depicts four distinct trajectories among Black females (n = 1 077). Figure 3B depicts two distinct trajectories among White females (n = 1 033). Figure 3C depicts three distinct trajectories among Black males (n = 794). Figure 3D depicts three distinct trajectories among Black males (n = 900).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219745&req=5

pone-0111647-g003: Ethnic-gender specific group-based trajectory of MetS development probability over a 20-year span as determined by PROC TRAJ censored normal modelling in 3 804 apparently healthy young adults.Figure 3A depicts four distinct trajectories among Black females (n = 1 077). Figure 3B depicts two distinct trajectories among White females (n = 1 033). Figure 3C depicts three distinct trajectories among Black males (n = 794). Figure 3D depicts three distinct trajectories among Black males (n = 900).
Mentions: Potential gender and ethnic differences within the cohort were also assessed, and gender- and ethnic-specific models were developed (Figure 3). Analyses yielded four distinct trajectories among black women, and two groups among white women. Amongst male participants, both black and white cohorts presented similar trajectory plots with three distinct groups each. Due to sample size constraints, extensive post-hoc analyses could not be conducted, meaning that predictive modeling was limited to the overall pooled trajectories (Figure 2).

Bottom Line: Data from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3 804; 18-30 y) was obtained by limited access application from the National Heart, Lung, and Blood Institute and used for this analysis.After adjusting for covariates, individuals in the At-Risk groups (Low, Moderate and High MetS) were more likely to be of black ethnicity (1.37, 1.14-1.66), have a family history of cardiovascular disease (1.61, 1.31-1.97) and history of dieting (1.69, 1.20-2.39) when compared to the No Risk trajectory group (No MetS).Conversely, increasing baseline education (0.76, 0.65-0.89) and aerobic fitness (0.55, 0.47-0.64) was inversely associated with At-Risk group membership.

View Article: PubMed Central - PubMed

Affiliation: School of Kinesiology and Health Science, York University, Toronto, ON, Canada.

ABSTRACT

Background: Metabolic syndrome (MetS) is a constellation of metabolic aberrations that collectively increase the risk for cardiovascular disease and type 2 diabetes. Greater understanding of MetS developments may provide insight into targeted prevention strategies for individuals at greatest risk. The purpose of this study was to i) identify distinct patterns of longitudinal MetS development and; ii) develop a character profile that differentiates groups by level of MetS risk.

Methods and results: Data from the Coronary Artery Risk Development in Young Adults (CARDIA) study (n = 3 804; 18-30 y) was obtained by limited access application from the National Heart, Lung, and Blood Institute and used for this analysis. MetS, as defined by the Harmonized criteria, was assessed over a 20 year follow-up period. Group-level trajectory analysis identified 4 distinct groups with varying rates of component development [No (23.8% of sample); Low (33.5%); Moderate (35.3%); and High MetS (7.4%)]. After adjusting for covariates, individuals in the At-Risk groups (Low, Moderate and High MetS) were more likely to be of black ethnicity (1.37, 1.14-1.66), have a family history of cardiovascular disease (1.61, 1.31-1.97) and history of dieting (1.69, 1.20-2.39) when compared to the No Risk trajectory group (No MetS). Conversely, increasing baseline education (0.76, 0.65-0.89) and aerobic fitness (0.55, 0.47-0.64) was inversely associated with At-Risk group membership.

Conclusions: Results suggest distinct profiles of MetS development that can be identified by baseline risk factors. Further research is necessary to understand the clinical implication of intermediate MetS development groups with respect to overall cardiometabolic risk.

Show MeSH
Related in: MedlinePlus