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Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.

Geng P, Zhao X, Xiang L, Liao Y, Wang N, Ou J, Xie G, Liu C, Li J, Li H, Zeng R, Liang H - PLoS ONE (2014)

Bottom Line: Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74-0.93; P(het)., 0.987; OR, 0.63; 95% CI, 0.50-0.79; P(het)., 0.973).The association was also observed in Caucasians and colorectal cancer.No obvious publication bias was detected in this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.

ABSTRACT

Background and purpose: Previous studies concerning the role of CD86 polymorphisms (rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this study was to investigate the role of common polymorphisms in the risk of cancer by meta-analysis.

Methods: By using the search terms Cluster of Differentiation 86/CD86/B7-2/polymorphism/polymorphisms/cancer, we searched PubMed, Embase, CNKI, and Wanfang and identified four studies for rs1129055 (2137 subjects) and rs17281995 (2856 subjects) respectively. Cancer risk was estimated by odds ratio (OR) and 95% confidence interval (95% CI).

Major findings: Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49-0.79; P(het)., 0.996). Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74-0.93; P(het)., 0.987; OR, 0.63; 95% CI, 0.50-0.79; P(het)., 0.973). In addition, we found genotypes of rs17281995 had a major effect on overall cancer risk (CC versus GG: OR, 2.38; 95% CI, 1.43-3.95; P(het)., 0.433; C versus G: OR, 1.23; 95% CI, 1.06-1.43; P(het)., 0.521; CC versus GC+GG: OR, 2.38; 95% CI, 1.45-3.93; P(het)., 0.443). The association was also observed in Caucasians and colorectal cancer. No obvious publication bias was detected in this meta-analysis.

Conclusions: These data reveal that rs1129055 may have protective effects on cancer risk in Asians and that rs17281995 is likely to contribute to risk of cancer, particularly colorectal cancer in Caucasians.

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Related in: MedlinePlus

Forest plot of estimates of the odds ratios (ORs) for CD86 polymorphisms in cancer under GG versus GA+AA for rs1129055 and CC versus GC+GG for rs17281995.The squares and horizontal lines correspond to ORs and 95% CIs of specific study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled ORs and its 95% CIs.
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pone-0109131-g003: Forest plot of estimates of the odds ratios (ORs) for CD86 polymorphisms in cancer under GG versus GA+AA for rs1129055 and CC versus GC+GG for rs17281995.The squares and horizontal lines correspond to ORs and 95% CIs of specific study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled ORs and its 95% CIs.

Mentions: By combining four studies of rs1129055, we yielded 2137 subjects for this meta-analysis. Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49–0.79; Phet., 0.996). Similar effects were also indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74–0.93; Phet., 0.987; OR, 0.63; 95% CI, 0.50–0.79; Phet., 0.973) (Figure 3). On the contrary, when we carried out comparisons between female and male, none of the genetic models showed effect modification of cancer risk. The studies were statistically homogeneous under all genetic models (Figure 2, Table 2).


Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.

Geng P, Zhao X, Xiang L, Liao Y, Wang N, Ou J, Xie G, Liu C, Li J, Li H, Zeng R, Liang H - PLoS ONE (2014)

Forest plot of estimates of the odds ratios (ORs) for CD86 polymorphisms in cancer under GG versus GA+AA for rs1129055 and CC versus GC+GG for rs17281995.The squares and horizontal lines correspond to ORs and 95% CIs of specific study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled ORs and its 95% CIs.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219668&req=5

pone-0109131-g003: Forest plot of estimates of the odds ratios (ORs) for CD86 polymorphisms in cancer under GG versus GA+AA for rs1129055 and CC versus GC+GG for rs17281995.The squares and horizontal lines correspond to ORs and 95% CIs of specific study, and the area of squares reflects study weight (inverse of the variance). The diamond represents the pooled ORs and its 95% CIs.
Mentions: By combining four studies of rs1129055, we yielded 2137 subjects for this meta-analysis. Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49–0.79; Phet., 0.996). Similar effects were also indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74–0.93; Phet., 0.987; OR, 0.63; 95% CI, 0.50–0.79; Phet., 0.973) (Figure 3). On the contrary, when we carried out comparisons between female and male, none of the genetic models showed effect modification of cancer risk. The studies were statistically homogeneous under all genetic models (Figure 2, Table 2).

Bottom Line: Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74-0.93; P(het)., 0.987; OR, 0.63; 95% CI, 0.50-0.79; P(het)., 0.973).The association was also observed in Caucasians and colorectal cancer.No obvious publication bias was detected in this meta-analysis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital Third Military Medical University, Chongqing, China.

ABSTRACT

Background and purpose: Previous studies concerning the role of CD86 polymorphisms (rs1129055 and rs17281995) in cancer fail to provide compelling evidence. The aim of this study was to investigate the role of common polymorphisms in the risk of cancer by meta-analysis.

Methods: By using the search terms Cluster of Differentiation 86/CD86/B7-2/polymorphism/polymorphisms/cancer, we searched PubMed, Embase, CNKI, and Wanfang and identified four studies for rs1129055 (2137 subjects) and rs17281995 (2856 subjects) respectively. Cancer risk was estimated by odds ratio (OR) and 95% confidence interval (95% CI).

Major findings: Overall, we observed significant reduced risk of cancer in relation to rs1129055. Compared with the individuals with AA genotype, the individuals with GG genotype appeared to have 62% decreased risk to develop cancer (GG versus AA: OR, 0.62; 95% CI, 0.49-0.79; P(het)., 0.996). Similar effects were indicated in the G versus A allele model and the GG versus GA+AA genetic model (OR, 0.83; 95% CI, 0.74-0.93; P(het)., 0.987; OR, 0.63; 95% CI, 0.50-0.79; P(het)., 0.973). In addition, we found genotypes of rs17281995 had a major effect on overall cancer risk (CC versus GG: OR, 2.38; 95% CI, 1.43-3.95; P(het)., 0.433; C versus G: OR, 1.23; 95% CI, 1.06-1.43; P(het)., 0.521; CC versus GC+GG: OR, 2.38; 95% CI, 1.45-3.93; P(het)., 0.443). The association was also observed in Caucasians and colorectal cancer. No obvious publication bias was detected in this meta-analysis.

Conclusions: These data reveal that rs1129055 may have protective effects on cancer risk in Asians and that rs17281995 is likely to contribute to risk of cancer, particularly colorectal cancer in Caucasians.

Show MeSH
Related in: MedlinePlus