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Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.


The spike generation properties and EPSP amplitude generated by a thalamic neurons to cortico-thalamic volleys is membrane potential depend. (A) At −70 mV the thalamic cell generated spikes at frequencies bellow 10 Hz. Note that the EPSPs generated are all of the same amplitude (bottom trace). (B) At a resting potential of −56 mV the EPSP amplitude for the same cortical volley was initially smaller, but increased in amplitude with stimulus frequency. It could follow high frequency stimulation and produce rapid neuronal spike firing. (From Pedroarena and Llinás, 2001.).
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Figure 10: The spike generation properties and EPSP amplitude generated by a thalamic neurons to cortico-thalamic volleys is membrane potential depend. (A) At −70 mV the thalamic cell generated spikes at frequencies bellow 10 Hz. Note that the EPSPs generated are all of the same amplitude (bottom trace). (B) At a resting potential of −56 mV the EPSP amplitude for the same cortical volley was initially smaller, but increased in amplitude with stimulus frequency. It could follow high frequency stimulation and produce rapid neuronal spike firing. (From Pedroarena and Llinás, 2001.).

Mentions: In addition to these voltage dependent conductances, thalamic neurons can modify their synaptic properties depending on membrane potential in a quite remarkable fashion. These properties are often not taken into account when considering their effects on arousal. Thus, fast reversible synaptic plasticity occurs in the thalamus by changes in postsynaptic membrane potential, independently of presynaptic volley size, and is rapidly reversible. It represents one of the few examples of rapid postsynaptically dependent synaptic plasticity as illustrated in Figure 10.


Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

The spike generation properties and EPSP amplitude generated by a thalamic neurons to cortico-thalamic volleys is membrane potential depend. (A) At −70 mV the thalamic cell generated spikes at frequencies bellow 10 Hz. Note that the EPSPs generated are all of the same amplitude (bottom trace). (B) At a resting potential of −56 mV the EPSP amplitude for the same cortical volley was initially smaller, but increased in amplitude with stimulus frequency. It could follow high frequency stimulation and produce rapid neuronal spike firing. (From Pedroarena and Llinás, 2001.).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219458&req=5

Figure 10: The spike generation properties and EPSP amplitude generated by a thalamic neurons to cortico-thalamic volleys is membrane potential depend. (A) At −70 mV the thalamic cell generated spikes at frequencies bellow 10 Hz. Note that the EPSPs generated are all of the same amplitude (bottom trace). (B) At a resting potential of −56 mV the EPSP amplitude for the same cortical volley was initially smaller, but increased in amplitude with stimulus frequency. It could follow high frequency stimulation and produce rapid neuronal spike firing. (From Pedroarena and Llinás, 2001.).
Mentions: In addition to these voltage dependent conductances, thalamic neurons can modify their synaptic properties depending on membrane potential in a quite remarkable fashion. These properties are often not taken into account when considering their effects on arousal. Thus, fast reversible synaptic plasticity occurs in the thalamus by changes in postsynaptic membrane potential, independently of presynaptic volley size, and is rapidly reversible. It represents one of the few examples of rapid postsynaptically dependent synaptic plasticity as illustrated in Figure 10.

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.