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Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.


Spontaneous bursts of spikes recorded intracellularly from an IO neuron displayed at different sweep speeds. (A) The neuron fired four action potentials and a fifth subthreshold response that corresponds to a subthreshold somatic Ca2+-dependent spike. (B) A longer burst of spikes is shown at a slower sweep speed. Note that the first interspike interval in the burst was longer than the rest. (C) The rising phase of the action potentials in (B) are superimposed to illustrate the change in after-depolarization duration during the train. Note that the first action potential (which arises from the resting membrane potential level) has the longest after-depolarization. The other spikes in the train became progressively shorter until failure of spike generation occurred and the burst terminated. (D) The same set of records as in (B), showing the duration of the after-hyperpolarization and the rebound somatic Ca2+-dependent spikes. (Modified from Llinás and Yarom, 1986).
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Figure 7: Spontaneous bursts of spikes recorded intracellularly from an IO neuron displayed at different sweep speeds. (A) The neuron fired four action potentials and a fifth subthreshold response that corresponds to a subthreshold somatic Ca2+-dependent spike. (B) A longer burst of spikes is shown at a slower sweep speed. Note that the first interspike interval in the burst was longer than the rest. (C) The rising phase of the action potentials in (B) are superimposed to illustrate the change in after-depolarization duration during the train. Note that the first action potential (which arises from the resting membrane potential level) has the longest after-depolarization. The other spikes in the train became progressively shorter until failure of spike generation occurred and the burst terminated. (D) The same set of records as in (B), showing the duration of the after-hyperpolarization and the rebound somatic Ca2+-dependent spikes. (Modified from Llinás and Yarom, 1986).

Mentions: The low threshold, transient calcium current is a powerful modulator of IO rhythmicity and is responsible for IO membrane potential oscillations. IO neuron oscillations can occur at two distinct frequencies, as determined by examining the firing properties of spontaneous bursts of spikes. A set of such events is shown in Figure 7.


Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Spontaneous bursts of spikes recorded intracellularly from an IO neuron displayed at different sweep speeds. (A) The neuron fired four action potentials and a fifth subthreshold response that corresponds to a subthreshold somatic Ca2+-dependent spike. (B) A longer burst of spikes is shown at a slower sweep speed. Note that the first interspike interval in the burst was longer than the rest. (C) The rising phase of the action potentials in (B) are superimposed to illustrate the change in after-depolarization duration during the train. Note that the first action potential (which arises from the resting membrane potential level) has the longest after-depolarization. The other spikes in the train became progressively shorter until failure of spike generation occurred and the burst terminated. (D) The same set of records as in (B), showing the duration of the after-hyperpolarization and the rebound somatic Ca2+-dependent spikes. (Modified from Llinás and Yarom, 1986).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219458&req=5

Figure 7: Spontaneous bursts of spikes recorded intracellularly from an IO neuron displayed at different sweep speeds. (A) The neuron fired four action potentials and a fifth subthreshold response that corresponds to a subthreshold somatic Ca2+-dependent spike. (B) A longer burst of spikes is shown at a slower sweep speed. Note that the first interspike interval in the burst was longer than the rest. (C) The rising phase of the action potentials in (B) are superimposed to illustrate the change in after-depolarization duration during the train. Note that the first action potential (which arises from the resting membrane potential level) has the longest after-depolarization. The other spikes in the train became progressively shorter until failure of spike generation occurred and the burst terminated. (D) The same set of records as in (B), showing the duration of the after-hyperpolarization and the rebound somatic Ca2+-dependent spikes. (Modified from Llinás and Yarom, 1986).
Mentions: The low threshold, transient calcium current is a powerful modulator of IO rhythmicity and is responsible for IO membrane potential oscillations. IO neuron oscillations can occur at two distinct frequencies, as determined by examining the firing properties of spontaneous bursts of spikes. A set of such events is shown in Figure 7.

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.