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Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.


Related in: MedlinePlus

Inward current in inferior olive cell after block of sodium and potassium currents with TTX and TEA, respectively. (A) A set of transmembrane square voltage camp steps of increasing amplitude generated a rapidly inactivating, transient, Ca current (Ica). (B) This current is blocked by addition of octanol. (C) Plot of the current voltage relation in (A). (From Llinás and Yarom in Llinás et al., 1989).
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Figure 6: Inward current in inferior olive cell after block of sodium and potassium currents with TTX and TEA, respectively. (A) A set of transmembrane square voltage camp steps of increasing amplitude generated a rapidly inactivating, transient, Ca current (Ica). (B) This current is blocked by addition of octanol. (C) Plot of the current voltage relation in (A). (From Llinás and Yarom in Llinás et al., 1989).

Mentions: A direct demonstration of time course and amplitude of the “low threshold” transient calcium current [ICA (T)], encountered in this neuron (Llinás and Yarom, 1981) is shown in Figure 6, following a voltage clamp study of IO neuronal calcium currents.


Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Inward current in inferior olive cell after block of sodium and potassium currents with TTX and TEA, respectively. (A) A set of transmembrane square voltage camp steps of increasing amplitude generated a rapidly inactivating, transient, Ca current (Ica). (B) This current is blocked by addition of octanol. (C) Plot of the current voltage relation in (A). (From Llinás and Yarom in Llinás et al., 1989).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219458&req=5

Figure 6: Inward current in inferior olive cell after block of sodium and potassium currents with TTX and TEA, respectively. (A) A set of transmembrane square voltage camp steps of increasing amplitude generated a rapidly inactivating, transient, Ca current (Ica). (B) This current is blocked by addition of octanol. (C) Plot of the current voltage relation in (A). (From Llinás and Yarom in Llinás et al., 1989).
Mentions: A direct demonstration of time course and amplitude of the “low threshold” transient calcium current [ICA (T)], encountered in this neuron (Llinás and Yarom, 1981) is shown in Figure 6, following a voltage clamp study of IO neuronal calcium currents.

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.


Related in: MedlinePlus