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Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.


High-resolution fluorescent image of a dendritic calcium spike in a Purkinje cell filled with fura-2 by microinjection (380-nm excitation). (From Tank et al., 1988.).
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Figure 3: High-resolution fluorescent image of a dendritic calcium spike in a Purkinje cell filled with fura-2 by microinjection (380-nm excitation). (From Tank et al., 1988.).

Mentions: An early experiment of this type was carried out 26 years ago by Tank et al. (1988). In these experiment Fura II signals were used to determine [Ca2+]i in Purkinje cells (Tank et al., 1988). Fura II was injected ionophoretically into the cell and a quantitative evaluation of changes in [Ca2+]i was made using the fluorescence ration at 340/380 nM as seen in Figure 3.


Intrinsic electrical properties of mammalian neurons and CNS function: a historical perspective.

Llinás RR - Front Cell Neurosci (2014)

High-resolution fluorescent image of a dendritic calcium spike in a Purkinje cell filled with fura-2 by microinjection (380-nm excitation). (From Tank et al., 1988.).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4219458&req=5

Figure 3: High-resolution fluorescent image of a dendritic calcium spike in a Purkinje cell filled with fura-2 by microinjection (380-nm excitation). (From Tank et al., 1988.).
Mentions: An early experiment of this type was carried out 26 years ago by Tank et al. (1988). In these experiment Fura II signals were used to determine [Ca2+]i in Purkinje cells (Tank et al., 1988). Fura II was injected ionophoretically into the cell and a quantitative evaluation of changes in [Ca2+]i was made using the fluorescence ration at 340/380 nM as seen in Figure 3.

Bottom Line: This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons.It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function.The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

View Article: PubMed Central - PubMed

Affiliation: Department of Neuroscience and Physiology, New York University School of Medicine New York, NY, USA.

ABSTRACT
This brief review summarizes work done in mammalian neuroscience concerning the intrinsic electrophysiological properties of four neuronal types; Cerebellar Purkinje cells, inferior olivary cells, thalamic cells, and some cortical interneurons. It is a personal perspective addressing an interesting time in neuroscience when the reflex view of brain function, as the paradigm to understand global neuroscience, began to be modified toward one in which sensory input modulates rather than dictates brain function. The perspective of the paper is not a comprehensive description of the intrinsic electrical properties of all nerve cells but rather addresses a set of cell types that provide indicative examples of mechanisms that modulate brain function.

No MeSH data available.