The role of gap junctions in stretch-induced atrial fibrillation.
Bottom Line: The effective refractory period (ERP) was measured, and the total conduction time (TCT) and the pattern of conduction of the anterior surface of the left atrium were monitored by using an optical mapping system.The effect of enhancing gap junction function by 100-1000 nM rotigaptide (ZP123) and block by 30 μM carbenoxolone on these parameters was measured.In the absence of gap junction enhancer or blocker, normal conduction was observed at 0 cmH2O.
Affiliation: Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan email@example.com.Show MeSH
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Mentions: Under control conditions, the ERP was significantly shortened by an increase in intra-atrial pressure. When intra-atrial pressure was raised from 0 to 20 cmH2O, ERP was significantly shortened from 74.5 ± 8.1 to 35.8 ± 4.3 ms (n = 8, Figure 5).Figure 5
Affiliation: Department of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan firstname.lastname@example.org.