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Adrenal steroids uniquely influence sexual motivation behavior in male rats.

Taylor GT, Dearborn JT, Maloney SE - Behav Sci (Basel) (2012)

Bottom Line: It was found that DHEA and 4-A supplements failed to influence time near the estrous female in the same way TS supplements did, and, indeed, 5 weeks of 4-A administration reduced the time similar to the suppressive effects of CORT after 3 weeks.Further, animals treated with DHEA or 4-A left fewer urinary marks near an estrous female than TS and control groups.These results suggest that DHEA and 4-A are not merely precursors of sex hormones, and provide support for these steroids influencing the brain and behavior in a unique fashion that is dissimilar from the effects of TS on male sexual behavior.

View Article: PubMed Central - PubMed

Affiliation: Behavioral Neuroscience Group, University of Missouri-St. Louis, 8001 Natural Bridge Road, St. Louis, MO 63110, USA; E-Mails: geot@umsl.edu (G.T.T.); sem885@mail.umsl.edu (S.E.M.).

ABSTRACT
The androgenic adrenal steroids dehydroepiandrosterone (DHEA) and 4α-androstenedione (4-A) have significant biological activity, but it is unclear if the behavioral effects are unique or only reflections of the effects of testosterone (TS). Gonadally intact male Long-Evans rats were assigned to groups to receive supplements of DHEA, 4-A, TS, corticosteroid (CORT), all at 400 µg steroid/kg of body weight, or vehicle only for 5 weeks. All males were tested in a paradigm for sexual motivation that measures time and urinary marks near an inaccessible receptive female. It was found that DHEA and 4-A supplements failed to influence time near the estrous female in the same way TS supplements did, and, indeed, 5 weeks of 4-A administration reduced the time similar to the suppressive effects of CORT after 3 weeks. Further, animals treated with DHEA or 4-A left fewer urinary marks near an estrous female than TS and control groups. These results suggest that DHEA and 4-A are not merely precursors of sex hormones, and provide support for these steroids influencing the brain and behavior in a unique fashion that is dissimilar from the effects of TS on male sexual behavior.

No MeSH data available.


Related in: MedlinePlus

Sexual Motivation Behavior. Mean (±SEM) time gonadally intact male rats given chronic steroid or vehicle supplement spent near estrous female during three weeks of 20-min sexual motivation trials. (*) TS significantly different from all other groups; (^) CORT significantly different from all other groups; (#) CORT significantly different from all other groups except 4-A.
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behavsci-02-00195-f001: Sexual Motivation Behavior. Mean (±SEM) time gonadally intact male rats given chronic steroid or vehicle supplement spent near estrous female during three weeks of 20-min sexual motivation trials. (*) TS significantly different from all other groups; (^) CORT significantly different from all other groups; (#) CORT significantly different from all other groups except 4-A.

Mentions: A repeated measures 5 × 3 ANOVA on the time near the receptive female in the sexual motivation paradigm revealed a significant interaction of drug and week (F8,110 = 9.336, p = 0.001). Further analyses with main effects allowed comparisons between treatment groups at each week of testing and within treatment groups across the three weeks. Between group analyses revealed time differences among the hormone treatments during the first week of sexual motivation testing (F4,55 = 21.700, p = 0.001). Subsequent comparisons with Tukey’s HSD tests (p < 0.05) indicated that males administered TS spent more time near the estrous female than the other males, and males administered CORT spent less time near the estrous female than all other groups (Figure 1). Androstenedione and DHEA did not differ from vehicle during the first week.


Adrenal steroids uniquely influence sexual motivation behavior in male rats.

Taylor GT, Dearborn JT, Maloney SE - Behav Sci (Basel) (2012)

Sexual Motivation Behavior. Mean (±SEM) time gonadally intact male rats given chronic steroid or vehicle supplement spent near estrous female during three weeks of 20-min sexual motivation trials. (*) TS significantly different from all other groups; (^) CORT significantly different from all other groups; (#) CORT significantly different from all other groups except 4-A.
© Copyright Policy - open access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4217631&req=5

behavsci-02-00195-f001: Sexual Motivation Behavior. Mean (±SEM) time gonadally intact male rats given chronic steroid or vehicle supplement spent near estrous female during three weeks of 20-min sexual motivation trials. (*) TS significantly different from all other groups; (^) CORT significantly different from all other groups; (#) CORT significantly different from all other groups except 4-A.
Mentions: A repeated measures 5 × 3 ANOVA on the time near the receptive female in the sexual motivation paradigm revealed a significant interaction of drug and week (F8,110 = 9.336, p = 0.001). Further analyses with main effects allowed comparisons between treatment groups at each week of testing and within treatment groups across the three weeks. Between group analyses revealed time differences among the hormone treatments during the first week of sexual motivation testing (F4,55 = 21.700, p = 0.001). Subsequent comparisons with Tukey’s HSD tests (p < 0.05) indicated that males administered TS spent more time near the estrous female than the other males, and males administered CORT spent less time near the estrous female than all other groups (Figure 1). Androstenedione and DHEA did not differ from vehicle during the first week.

Bottom Line: It was found that DHEA and 4-A supplements failed to influence time near the estrous female in the same way TS supplements did, and, indeed, 5 weeks of 4-A administration reduced the time similar to the suppressive effects of CORT after 3 weeks.Further, animals treated with DHEA or 4-A left fewer urinary marks near an estrous female than TS and control groups.These results suggest that DHEA and 4-A are not merely precursors of sex hormones, and provide support for these steroids influencing the brain and behavior in a unique fashion that is dissimilar from the effects of TS on male sexual behavior.

View Article: PubMed Central - PubMed

Affiliation: Behavioral Neuroscience Group, University of Missouri-St. Louis, 8001 Natural Bridge Road, St. Louis, MO 63110, USA; E-Mails: geot@umsl.edu (G.T.T.); sem885@mail.umsl.edu (S.E.M.).

ABSTRACT
The androgenic adrenal steroids dehydroepiandrosterone (DHEA) and 4α-androstenedione (4-A) have significant biological activity, but it is unclear if the behavioral effects are unique or only reflections of the effects of testosterone (TS). Gonadally intact male Long-Evans rats were assigned to groups to receive supplements of DHEA, 4-A, TS, corticosteroid (CORT), all at 400 µg steroid/kg of body weight, or vehicle only for 5 weeks. All males were tested in a paradigm for sexual motivation that measures time and urinary marks near an inaccessible receptive female. It was found that DHEA and 4-A supplements failed to influence time near the estrous female in the same way TS supplements did, and, indeed, 5 weeks of 4-A administration reduced the time similar to the suppressive effects of CORT after 3 weeks. Further, animals treated with DHEA or 4-A left fewer urinary marks near an estrous female than TS and control groups. These results suggest that DHEA and 4-A are not merely precursors of sex hormones, and provide support for these steroids influencing the brain and behavior in a unique fashion that is dissimilar from the effects of TS on male sexual behavior.

No MeSH data available.


Related in: MedlinePlus