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Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer.

Huang J, Wu J, Li Y, Li X, Yang T, Yang Q, Jiang Y - Biomed Res Int (2014)

Bottom Line: The differentially expressed miRNAs were then confirmed in a larger sample.The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively.In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Respiratory Diseases, Institute for Chemical Carcinogenesis, Guangzhou Medical University, 195 Dongfeng Road West, Guangzhou 510182, China ; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

ABSTRACT
Lung cancer is the leading cause of cancer-related death and cigarette smoking is the main risk factor for lung cancer. Circulating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer. However, it is unclear whether changes in circulating miRNAs are associated with smoking and smoking-related lung cancer. In this study, we determined the serum miRNA profiles of 10 nonsmokers, 10 smokers, and 10 lung-cancer patients with miRCURY LNA microRNA arrays. The differentially expressed miRNAs were then confirmed in a larger sample. We found that let-7i-3p and miR-154-5p were significantly downregulated in the sera of smokers and lung-cancer patients, so the serum levels of let-7i-3p and miR-154-5p are associated with smoking and smoking-related lung cancer. The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively. In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.

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Related in: MedlinePlus

Evaluation of serums let-7i-3p and miR-154-5p as potential biomarkers of smoking-related lung cancer. Receiver operating characteristic (ROC) curve analyses of serums let-7i-3p (a) and miR-154-5p (b) were performed to discriminate patients with smoking-related lung cancer from nonsmokers. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively.
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fig5: Evaluation of serums let-7i-3p and miR-154-5p as potential biomarkers of smoking-related lung cancer. Receiver operating characteristic (ROC) curve analyses of serums let-7i-3p (a) and miR-154-5p (b) were performed to discriminate patients with smoking-related lung cancer from nonsmokers. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively.

Mentions: A ROC curve analysis was performed to evaluate the sensitivity and specificity of let-7i-3p and miR-154-5p as biomarkers of smoking-related lung cancer. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively (Figures 5(a) and 5(b)). These results indicate that serums let-7i-3p and miR-154-5p levels can potentially be used as biomarkers to distinguish smoking-related lung-cancer patients from nonsmoking controls.


Deregulation of serum microRNA expression is associated with cigarette smoking and lung cancer.

Huang J, Wu J, Li Y, Li X, Yang T, Yang Q, Jiang Y - Biomed Res Int (2014)

Evaluation of serums let-7i-3p and miR-154-5p as potential biomarkers of smoking-related lung cancer. Receiver operating characteristic (ROC) curve analyses of serums let-7i-3p (a) and miR-154-5p (b) were performed to discriminate patients with smoking-related lung cancer from nonsmokers. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4217347&req=5

fig5: Evaluation of serums let-7i-3p and miR-154-5p as potential biomarkers of smoking-related lung cancer. Receiver operating characteristic (ROC) curve analyses of serums let-7i-3p (a) and miR-154-5p (b) were performed to discriminate patients with smoking-related lung cancer from nonsmokers. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively.
Mentions: A ROC curve analysis was performed to evaluate the sensitivity and specificity of let-7i-3p and miR-154-5p as biomarkers of smoking-related lung cancer. The AUCs for serums let-7i-3p and miR-154-5p were 0.892 and 0.957, respectively (Figures 5(a) and 5(b)). These results indicate that serums let-7i-3p and miR-154-5p levels can potentially be used as biomarkers to distinguish smoking-related lung-cancer patients from nonsmoking controls.

Bottom Line: The differentially expressed miRNAs were then confirmed in a larger sample.The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively.In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.

View Article: PubMed Central - PubMed

Affiliation: State Key Laboratory of Respiratory Diseases, Institute for Chemical Carcinogenesis, Guangzhou Medical University, 195 Dongfeng Road West, Guangzhou 510182, China ; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

ABSTRACT
Lung cancer is the leading cause of cancer-related death and cigarette smoking is the main risk factor for lung cancer. Circulating microRNAs (miRNAs) are considered potential biomarkers of various cancers, including lung cancer. However, it is unclear whether changes in circulating miRNAs are associated with smoking and smoking-related lung cancer. In this study, we determined the serum miRNA profiles of 10 nonsmokers, 10 smokers, and 10 lung-cancer patients with miRCURY LNA microRNA arrays. The differentially expressed miRNAs were then confirmed in a larger sample. We found that let-7i-3p and miR-154-5p were significantly downregulated in the sera of smokers and lung-cancer patients, so the serum levels of let-7i-3p and miR-154-5p are associated with smoking and smoking-related lung cancer. The areas under receiver operating characteristic curves for let-7i-3p and miR-154-5p were approximately 0.892 and 0.957, respectively. In conclusion, our results indicate that changes in serum miRNAs are associated with cigarette smoking and lung cancer and that let-7i-3p and miR-154-5p are potential biomarkers of smoking-related lung cancer.

Show MeSH
Related in: MedlinePlus