Limits...
Book Review: Toxicologic Pathology, Nonclinical Safety Assessment

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Various chemicals are used as foods, personal care products and prescription drugs... Theeffects of many of these chemicals on our health have not been clear, yet we may be exposed tothem while manufacturing, using and disposing of them... It could be said that this is the mostpractical textbook directly available for toxicological research that has been published inrecent years... Also, for regulatory scientists and basic researchers involved in drug safetyevaluation in government and academic areas, this book will provide valuable information totheir work... The first section includes eight chapters for pathologists in areas that areimportant for effective interaction with many non-pathologists involved in drug development:regulatory issues, general toxicity studies, toxicokinetics, clinical pathology, routinetoxicologic pathology, digital imaging, toxicogenomics, and historical control data oflaboratory animals... Each section includes embryology,comparative biology, gross and microscopic anatomy, light and electron microscopicdescriptions of pathological lesions, mechanism of lesion formation, expected clinicalpathology including the biomarkers and/or relevance of chemical-induced lesions to humans.Toxicological lesions of laboratory animals (rats, mice, dogs, monkeys, rabbits, and/orminipigs) are covered in this book... This book will be a highly valuable aid for toxicologic pathologists working inpharmaceutical drug research at all stages of their training or career... Also, it has beencrafted to assist students and residents by serving as a resource that can effectively be usedas a ready reference next to the microscope... In order to meet the increasing demand to verifythe quality of pathological and toxicological assessments in safety testing for chemicals,three board certification systems have been established in Japan in independent categories ofscience: one for toxicologic pathologists by the Japanese Society of Toxicologic Pathology(JSTP), one for veterinary pathologists by the Japanese College of Veterinary Pathologists(JCVP), and one for toxicologists by the Japanese Society of Toxicology (JST)... There are several purchasingoptions available to readers for this textbook, such as the hardback version, ebook version(full), ebook rental version (6 or 12 months) and PDF version of each chapter ($20.00 for 72hrs access)... In summary, this is an excellent and very relevant textbook for all new and practicingtoxicologic pathologists and indeed, anyone involved in generating, interpreting or reviewingchemical-induced pathological data... The author of this review thoroughly recommends this bookfor toxicologic pathologists, toxicologists and regulators working with drug and otherchemical safety in Japan... It will be a must-have reference book in this scientific field.

No MeSH data available.


© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4217229&req=5

Mentions: Various chemicals are used as foods, personal care products and prescription drugs. Theeffects of many of these chemicals on our health have not been clear, yet we may be exposed tothem while manufacturing, using and disposing of them. In general, the goal of toxicologicpathologists is to understand both what the effects of these chemicals and new candidate drugsare and at what levels of exposure they may become hazardous to humans. Recently, some bookshave been published on the subjects of preclinical histopathology and toxicology, but nonehave been like the new book edited by Drs. Sahota, Popp, Hardisty and Gopinath (Fig. 1Fig. 1.). These editors have contributed to the academicareas of toxicology and toxicologic pathology for many years. Many scientists must know themand collaborate with them in this field worldwide. It could be said that this is the mostpractical textbook directly available for toxicological research that has been published inrecent years. Also, for regulatory scientists and basic researchers involved in drug safetyevaluation in government and academic areas, this book will provide valuable information totheir work.


Book Review: Toxicologic Pathology, Nonclinical Safety Assessment
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4217229&req=5

Mentions: Various chemicals are used as foods, personal care products and prescription drugs. Theeffects of many of these chemicals on our health have not been clear, yet we may be exposed tothem while manufacturing, using and disposing of them. In general, the goal of toxicologicpathologists is to understand both what the effects of these chemicals and new candidate drugsare and at what levels of exposure they may become hazardous to humans. Recently, some bookshave been published on the subjects of preclinical histopathology and toxicology, but nonehave been like the new book edited by Drs. Sahota, Popp, Hardisty and Gopinath (Fig. 1Fig. 1.). These editors have contributed to the academicareas of toxicology and toxicologic pathology for many years. Many scientists must know themand collaborate with them in this field worldwide. It could be said that this is the mostpractical textbook directly available for toxicological research that has been published inrecent years. Also, for regulatory scientists and basic researchers involved in drug safetyevaluation in government and academic areas, this book will provide valuable information totheir work.

View Article: PubMed Central

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Various chemicals are used as foods, personal care products and prescription drugs... Theeffects of many of these chemicals on our health have not been clear, yet we may be exposed tothem while manufacturing, using and disposing of them... It could be said that this is the mostpractical textbook directly available for toxicological research that has been published inrecent years... Also, for regulatory scientists and basic researchers involved in drug safetyevaluation in government and academic areas, this book will provide valuable information totheir work... The first section includes eight chapters for pathologists in areas that areimportant for effective interaction with many non-pathologists involved in drug development:regulatory issues, general toxicity studies, toxicokinetics, clinical pathology, routinetoxicologic pathology, digital imaging, toxicogenomics, and historical control data oflaboratory animals... Each section includes embryology,comparative biology, gross and microscopic anatomy, light and electron microscopicdescriptions of pathological lesions, mechanism of lesion formation, expected clinicalpathology including the biomarkers and/or relevance of chemical-induced lesions to humans.Toxicological lesions of laboratory animals (rats, mice, dogs, monkeys, rabbits, and/orminipigs) are covered in this book... This book will be a highly valuable aid for toxicologic pathologists working inpharmaceutical drug research at all stages of their training or career... Also, it has beencrafted to assist students and residents by serving as a resource that can effectively be usedas a ready reference next to the microscope... In order to meet the increasing demand to verifythe quality of pathological and toxicological assessments in safety testing for chemicals,three board certification systems have been established in Japan in independent categories ofscience: one for toxicologic pathologists by the Japanese Society of Toxicologic Pathology(JSTP), one for veterinary pathologists by the Japanese College of Veterinary Pathologists(JCVP), and one for toxicologists by the Japanese Society of Toxicology (JST)... There are several purchasingoptions available to readers for this textbook, such as the hardback version, ebook version(full), ebook rental version (6 or 12 months) and PDF version of each chapter ($20.00 for 72hrs access)... In summary, this is an excellent and very relevant textbook for all new and practicingtoxicologic pathologists and indeed, anyone involved in generating, interpreting or reviewingchemical-induced pathological data... The author of this review thoroughly recommends this bookfor toxicologic pathologists, toxicologists and regulators working with drug and otherchemical safety in Japan... It will be a must-have reference book in this scientific field.

No MeSH data available.