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A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin.

Dalby AR, Iqbal M - PeerJ (2014)

Bottom Line: The results of this analysis are also consistent with a model where hemagglutinin has predominantly evolved by neutral drift punctuated by occasional selection events.These selective events have produced the current pattern of distinct lineages in the Middle East, Korea and China.This interpretation is in agreement with existing studies that have shown that there is widespread intra-country sequence evolution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Science and Technology, University of Westminster , Westminster , UK.

ABSTRACT
A complete phylogenetic analysis of all of the H9N2 hemagglutinin sequences that were collected between 1966 and 2012 was carried out in order to build a picture of the geographical and host specific evolution of the hemagglutinin protein. To improve the quality and applicability of the output data the sequences were divided into subsets based upon location and host species. The phylogenetic analysis of hemagglutinin reveals that the protein has distinct lineages between China and the Middle East, and that wild birds in both regions retain a distinct form of the H9 molecule, from the same lineage as the ancestral hemagglutinin. The results add further evidence to the hypothesis that the current predominant H9N2 hemagglutinin lineage might have originated in Southern China. The study also shows that there are sampling problems that affect the reliability of this and any similar analysis. This raises questions about the surveillance of H9N2 and the need for wider sampling of the virus in the environment. The results of this analysis are also consistent with a model where hemagglutinin has predominantly evolved by neutral drift punctuated by occasional selection events. These selective events have produced the current pattern of distinct lineages in the Middle East, Korea and China. This interpretation is in agreement with existing studies that have shown that there is widespread intra-country sequence evolution.

No MeSH data available.


Related in: MedlinePlus

The Iranian and Israeli nucleotide and amino acid phylogenetic trees.(A) The Iranian nucleotide phylogenetic tree, (B) The Iranian amino acid phylogenetic tree, (C) The Israeli nucleotide phylogenetic tree, (D) The Israeli amino acid phylogenetic tree.
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fig-7: The Iranian and Israeli nucleotide and amino acid phylogenetic trees.(A) The Iranian nucleotide phylogenetic tree, (B) The Iranian amino acid phylogenetic tree, (C) The Israeli nucleotide phylogenetic tree, (D) The Israeli amino acid phylogenetic tree.

Mentions: The protein and nucleotide phylogenetic trees for Israel and Iran are shown in Fig. 7. In the Iranian tree Clade 1 are duck sequences from Clade A. This is why this clade has the deepest origin within the tree, but it does not contain the earliest sequences. This shows that wild birds can introduce other lineages to a geographical region where another lineage currently dominates.


A global phylogenetic analysis in order to determine the host species and geography dependent features present in the evolution of avian H9N2 influenza hemagglutinin.

Dalby AR, Iqbal M - PeerJ (2014)

The Iranian and Israeli nucleotide and amino acid phylogenetic trees.(A) The Iranian nucleotide phylogenetic tree, (B) The Iranian amino acid phylogenetic tree, (C) The Israeli nucleotide phylogenetic tree, (D) The Israeli amino acid phylogenetic tree.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4217197&req=5

fig-7: The Iranian and Israeli nucleotide and amino acid phylogenetic trees.(A) The Iranian nucleotide phylogenetic tree, (B) The Iranian amino acid phylogenetic tree, (C) The Israeli nucleotide phylogenetic tree, (D) The Israeli amino acid phylogenetic tree.
Mentions: The protein and nucleotide phylogenetic trees for Israel and Iran are shown in Fig. 7. In the Iranian tree Clade 1 are duck sequences from Clade A. This is why this clade has the deepest origin within the tree, but it does not contain the earliest sequences. This shows that wild birds can introduce other lineages to a geographical region where another lineage currently dominates.

Bottom Line: The results of this analysis are also consistent with a model where hemagglutinin has predominantly evolved by neutral drift punctuated by occasional selection events.These selective events have produced the current pattern of distinct lineages in the Middle East, Korea and China.This interpretation is in agreement with existing studies that have shown that there is widespread intra-country sequence evolution.

View Article: PubMed Central - HTML - PubMed

Affiliation: Faculty of Science and Technology, University of Westminster , Westminster , UK.

ABSTRACT
A complete phylogenetic analysis of all of the H9N2 hemagglutinin sequences that were collected between 1966 and 2012 was carried out in order to build a picture of the geographical and host specific evolution of the hemagglutinin protein. To improve the quality and applicability of the output data the sequences were divided into subsets based upon location and host species. The phylogenetic analysis of hemagglutinin reveals that the protein has distinct lineages between China and the Middle East, and that wild birds in both regions retain a distinct form of the H9 molecule, from the same lineage as the ancestral hemagglutinin. The results add further evidence to the hypothesis that the current predominant H9N2 hemagglutinin lineage might have originated in Southern China. The study also shows that there are sampling problems that affect the reliability of this and any similar analysis. This raises questions about the surveillance of H9N2 and the need for wider sampling of the virus in the environment. The results of this analysis are also consistent with a model where hemagglutinin has predominantly evolved by neutral drift punctuated by occasional selection events. These selective events have produced the current pattern of distinct lineages in the Middle East, Korea and China. This interpretation is in agreement with existing studies that have shown that there is widespread intra-country sequence evolution.

No MeSH data available.


Related in: MedlinePlus