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Interleukin-7 and interleukin-15 for cancer.

Zarogoulidis P, Lampaki S, Yarmus L, Kioumis I, Pitsiou G, Katsikogiannis N, Hohenforst-Schmidt W, Li Q, Huang H, Sakkas A, Organtzis J, Sakkas L, Mpoukovinas I, Tsakiridis K, Lazaridis G, Syrigos K, Zarogoulidis K - J Cancer (2014)

Bottom Line: Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis.Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation.Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

ABSTRACT
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

No MeSH data available.


Related in: MedlinePlus

IL; interleukin, RANKL; receptor activator of nuclear factor-α, TNF-α; tumor necrosis factor, PI3K; phosphatidyl-inositol-3-kinase, STAT3-5; mammalian family members 3-5, Ras/Raf/Erk:Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade, MICA/B; major histocompatibility complex class I-related chain A and B, NK; natural killer cells, IFN-α,β,γ; Interferons α,β,γ, ΤΗ1-2; effector T-cells. Akt; also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase, Anti-CTLA-4; Cytotoxic T-Lymphocyte Antigen 4, PD-L1; Programmed cell death 1 ligand 1.
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Figure 2: IL; interleukin, RANKL; receptor activator of nuclear factor-α, TNF-α; tumor necrosis factor, PI3K; phosphatidyl-inositol-3-kinase, STAT3-5; mammalian family members 3-5, Ras/Raf/Erk:Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade, MICA/B; major histocompatibility complex class I-related chain A and B, NK; natural killer cells, IFN-α,β,γ; Interferons α,β,γ, ΤΗ1-2; effector T-cells. Akt; also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase, Anti-CTLA-4; Cytotoxic T-Lymphocyte Antigen 4, PD-L1; Programmed cell death 1 ligand 1.


Interleukin-7 and interleukin-15 for cancer.

Zarogoulidis P, Lampaki S, Yarmus L, Kioumis I, Pitsiou G, Katsikogiannis N, Hohenforst-Schmidt W, Li Q, Huang H, Sakkas A, Organtzis J, Sakkas L, Mpoukovinas I, Tsakiridis K, Lazaridis G, Syrigos K, Zarogoulidis K - J Cancer (2014)

IL; interleukin, RANKL; receptor activator of nuclear factor-α, TNF-α; tumor necrosis factor, PI3K; phosphatidyl-inositol-3-kinase, STAT3-5; mammalian family members 3-5, Ras/Raf/Erk:Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade, MICA/B; major histocompatibility complex class I-related chain A and B, NK; natural killer cells, IFN-α,β,γ; Interferons α,β,γ, ΤΗ1-2; effector T-cells. Akt; also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase, Anti-CTLA-4; Cytotoxic T-Lymphocyte Antigen 4, PD-L1; Programmed cell death 1 ligand 1.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4216801&req=5

Figure 2: IL; interleukin, RANKL; receptor activator of nuclear factor-α, TNF-α; tumor necrosis factor, PI3K; phosphatidyl-inositol-3-kinase, STAT3-5; mammalian family members 3-5, Ras/Raf/Erk:Ras/Raf/Mitogen-activated protein kinase/ERK kinase (MEK)/extracellular-signal-regulated kinase (ERK) cascade, MICA/B; major histocompatibility complex class I-related chain A and B, NK; natural killer cells, IFN-α,β,γ; Interferons α,β,γ, ΤΗ1-2; effector T-cells. Akt; also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase, Anti-CTLA-4; Cytotoxic T-Lymphocyte Antigen 4, PD-L1; Programmed cell death 1 ligand 1.
Bottom Line: Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis.Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation.Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

ABSTRACT
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

No MeSH data available.


Related in: MedlinePlus