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Interleukin-7 and interleukin-15 for cancer.

Zarogoulidis P, Lampaki S, Yarmus L, Kioumis I, Pitsiou G, Katsikogiannis N, Hohenforst-Schmidt W, Li Q, Huang H, Sakkas A, Organtzis J, Sakkas L, Mpoukovinas I, Tsakiridis K, Lazaridis G, Syrigos K, Zarogoulidis K - J Cancer (2014)

Bottom Line: Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis.Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation.Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

ABSTRACT
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

No MeSH data available.


Related in: MedlinePlus

IL; interleukin, NK; natural killer cells, CD4-8+ T cells; subfamily of T cells, FasL; Fas ligand, a transmembrane protein part of the Tumor Necrosis Family. The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10.
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Figure 1: IL; interleukin, NK; natural killer cells, CD4-8+ T cells; subfamily of T cells, FasL; Fas ligand, a transmembrane protein part of the Tumor Necrosis Family. The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10.

Mentions: In the study by Fritzell et. al. 13 in a rat glioma model dual immunotherapy was administered with interferon-γ and IL-7 and increased survival was observed via increased T-cell proliferation. In another model of dual immunotherapy it was observed that combination of IL-7 and IL-2 has the highest rate of effectiveness, when compared to IL-7 alone or IL-2. Additionally, when comparing the following interleukin 2,4 and 7 the effectiveness of each one alone as a immunotherapy is demonstrated as follows: IL-7>IL-2>IL-4 56. (Figure 1) Furthermore, in the study by Touw et. al. 57 recombinant IL-7 was administered in ALL cell lines and patients with ALL. 128I-IL-7 binding experiments demonstrated that there are two types of receptors: high affinity and low affinity. The authors concluded again that IL-7 plays a major role in the regulation of ALL cell proliferation. Gene therapy expressing IL-7 with transduced bone marrow cells was also observed to be effective in in vivo of allogenic bone marrow transplantation 58. In the study by Consolini et. al. 59 (37 childhood patients) IL-4, IL-7 stem cell factor (SCF) and insulin like growth factor-1 (IGF-1) were used in Nalm 1 and Nalm 6. These are two acute lymphoblastic leukemia cell lines (ALL) derived from pre-B cell lines. Il-7 co-administration with hyperthermia has been also used as a combination to immunotherapy in a melanoma in vivo model 60. Il-7 administration has been also found effective in renal carcinoma 61.


Interleukin-7 and interleukin-15 for cancer.

Zarogoulidis P, Lampaki S, Yarmus L, Kioumis I, Pitsiou G, Katsikogiannis N, Hohenforst-Schmidt W, Li Q, Huang H, Sakkas A, Organtzis J, Sakkas L, Mpoukovinas I, Tsakiridis K, Lazaridis G, Syrigos K, Zarogoulidis K - J Cancer (2014)

IL; interleukin, NK; natural killer cells, CD4-8+ T cells; subfamily of T cells, FasL; Fas ligand, a transmembrane protein part of the Tumor Necrosis Family. The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC4216801&req=5

Figure 1: IL; interleukin, NK; natural killer cells, CD4-8+ T cells; subfamily of T cells, FasL; Fas ligand, a transmembrane protein part of the Tumor Necrosis Family. The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), which contains the FADD, caspase-8 and caspase-10.
Mentions: In the study by Fritzell et. al. 13 in a rat glioma model dual immunotherapy was administered with interferon-γ and IL-7 and increased survival was observed via increased T-cell proliferation. In another model of dual immunotherapy it was observed that combination of IL-7 and IL-2 has the highest rate of effectiveness, when compared to IL-7 alone or IL-2. Additionally, when comparing the following interleukin 2,4 and 7 the effectiveness of each one alone as a immunotherapy is demonstrated as follows: IL-7>IL-2>IL-4 56. (Figure 1) Furthermore, in the study by Touw et. al. 57 recombinant IL-7 was administered in ALL cell lines and patients with ALL. 128I-IL-7 binding experiments demonstrated that there are two types of receptors: high affinity and low affinity. The authors concluded again that IL-7 plays a major role in the regulation of ALL cell proliferation. Gene therapy expressing IL-7 with transduced bone marrow cells was also observed to be effective in in vivo of allogenic bone marrow transplantation 58. In the study by Consolini et. al. 59 (37 childhood patients) IL-4, IL-7 stem cell factor (SCF) and insulin like growth factor-1 (IGF-1) were used in Nalm 1 and Nalm 6. These are two acute lymphoblastic leukemia cell lines (ALL) derived from pre-B cell lines. Il-7 co-administration with hyperthermia has been also used as a combination to immunotherapy in a melanoma in vivo model 60. Il-7 administration has been also found effective in renal carcinoma 61.

Bottom Line: Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis.Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation.Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: 1. Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

ABSTRACT
Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

No MeSH data available.


Related in: MedlinePlus