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The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine.

Lee MH, Ko JH, Kim EM, Cheung MH, Choi YR, Choi EM - Korean J Anesthesiol (2014)

Bottom Line: The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group.However, there were no patients with oxygen desaturation in dexmedetomidine groups.The incidences of hypotension and bradycardia showed no differences among the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.

Methods: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.

Results: The two-dermatome pinprick sensory regression time (57.6 ± 23.2 vs 86.5 ± 24.3 vs 92.5 ± 30.7, P = 0.0002) and duration of the motor block (98.8 ± 34.1 vs 132.9 ± 43.4 vs 130.4 ± 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.

Conclusions: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.

No MeSH data available.


Related in: MedlinePlus

Ramsay sedation score. Values are presented as mean ± SD. *P < 0.05 when compared to control group. †P < 0.05 D-1 group when compared to the value in the D-0.5 group at the same time point.
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Figure 2: Ramsay sedation score. Values are presented as mean ± SD. *P < 0.05 when compared to control group. †P < 0.05 D-1 group when compared to the value in the D-0.5 group at the same time point.

Mentions: Fig. 2 shows the RSS at each time point. The RSS were significantly increased in the dexmedetomidine groups than in the control group after following injection of dexmedetomidine. In addition, in the D-1 groups the RSS were significantly higher than in the D-0.5 group. The excessive sedation (RSS > 4) was observed in 1 of 20 patients and 5 of 20 patients in the D-0.5 and D-1 groups, respectively. However, there were no patients with oxygen desaturation among the three groups (Table 3). The regression time of the RSS (< 3) was 83.6 ± 40.4 and 89.9 ± 42.7 in the D-0.5 and D-1 groups, respectively.


The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine.

Lee MH, Ko JH, Kim EM, Cheung MH, Choi YR, Choi EM - Korean J Anesthesiol (2014)

Ramsay sedation score. Values are presented as mean ± SD. *P < 0.05 when compared to control group. †P < 0.05 D-1 group when compared to the value in the D-0.5 group at the same time point.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4216787&req=5

Figure 2: Ramsay sedation score. Values are presented as mean ± SD. *P < 0.05 when compared to control group. †P < 0.05 D-1 group when compared to the value in the D-0.5 group at the same time point.
Mentions: Fig. 2 shows the RSS at each time point. The RSS were significantly increased in the dexmedetomidine groups than in the control group after following injection of dexmedetomidine. In addition, in the D-1 groups the RSS were significantly higher than in the D-0.5 group. The excessive sedation (RSS > 4) was observed in 1 of 20 patients and 5 of 20 patients in the D-0.5 and D-1 groups, respectively. However, there were no patients with oxygen desaturation among the three groups (Table 3). The regression time of the RSS (< 3) was 83.6 ± 40.4 and 89.9 ± 42.7 in the D-0.5 and D-1 groups, respectively.

Bottom Line: The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group.However, there were no patients with oxygen desaturation in dexmedetomidine groups.The incidences of hypotension and bradycardia showed no differences among the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.

Methods: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.

Results: The two-dermatome pinprick sensory regression time (57.6 ± 23.2 vs 86.5 ± 24.3 vs 92.5 ± 30.7, P = 0.0002) and duration of the motor block (98.8 ± 34.1 vs 132.9 ± 43.4 vs 130.4 ± 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.

Conclusions: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.

No MeSH data available.


Related in: MedlinePlus