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The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine.

Lee MH, Ko JH, Kim EM, Cheung MH, Choi YR, Choi EM - Korean J Anesthesiol (2014)

Bottom Line: The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group.However, there were no patients with oxygen desaturation in dexmedetomidine groups.The incidences of hypotension and bradycardia showed no differences among the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.

Methods: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.

Results: The two-dermatome pinprick sensory regression time (57.6 ± 23.2 vs 86.5 ± 24.3 vs 92.5 ± 30.7, P = 0.0002) and duration of the motor block (98.8 ± 34.1 vs 132.9 ± 43.4 vs 130.4 ± 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.

Conclusions: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.

No MeSH data available.


Related in: MedlinePlus

Flow diagram of the randomized, controlled trial.
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Figure 1: Flow diagram of the randomized, controlled trial.

Mentions: Sixty patients were enrolled in this study, and none were excluded or failed to complete (Fig. 1). In total, data from 60 patients were analyzed, with no differences observed in any of the demographic variables (Table 1).


The effects of intravenous dexmedetomidine on spinal anesthesia: comparision of different dose of dexmedetomidine.

Lee MH, Ko JH, Kim EM, Cheung MH, Choi YR, Choi EM - Korean J Anesthesiol (2014)

Flow diagram of the randomized, controlled trial.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4216787&req=5

Figure 1: Flow diagram of the randomized, controlled trial.
Mentions: Sixty patients were enrolled in this study, and none were excluded or failed to complete (Fig. 1). In total, data from 60 patients were analyzed, with no differences observed in any of the demographic variables (Table 1).

Bottom Line: The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group.However, there were no patients with oxygen desaturation in dexmedetomidine groups.The incidences of hypotension and bradycardia showed no differences among the three groups.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology and Pain Medicine, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

ABSTRACT

Background: In this prospective, randomized, double-blind, placebo-controlled trial, we tried to find out appropriate amounts of single-dose dexmedetomidine to prolong the duration of spinal anesthesia in a clinical setting.

Methods: Sixty patients who were scheduled for unilateral lower limb surgery under spinal anesthesia were randomized into three groups receiving normal saline (control group, n = 20) or 0.5 or 1.0 ug/kg dexmedetomidine (D-0.5 group, n = 20; D-1, n = 20) intravenously prior to spinal anesthesia with 12 mg of bupivacaine. The two-dermatome pinprick sensory regression time, duration of the motor block, Ramsay sedation score (RSS), and side effects of dexmedetomidine were assessed.

Results: The two-dermatome pinprick sensory regression time (57.6 ± 23.2 vs 86.5 ± 24.3 vs 92.5 ± 30.7, P = 0.0002) and duration of the motor block (98.8 ± 34.1 vs 132.9 ± 43.4 vs 130.4 ± 50.4, P = 0.0261) were significantly increased in the D-0.5 and D-1 groups than in the control group. The RSS were significantly higher in the D-0.5 and D-1 groups than in the control group. However, there were no patients with oxygen desaturation in dexmedetomidine groups. The incidences of hypotension and bradycardia showed no differences among the three groups.

Conclusions: Both 0.5 and 1.0 ug/kg of dexmedetomidine administered as isolated boluses in the absence of maintenance infusions prolonged the duration of spinal anesthesia.

No MeSH data available.


Related in: MedlinePlus