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Serum fetuin-A levels in patients with cardiovascular disease: a meta-analysis.

Sun ZL, Xie QY, Guo GL, Ma K, Huang YY - Biomed Res Int (2014)

Bottom Line: Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD=1.36, 95%CI: 0.37-2.36, P=0.007).The data indicated that decreased serum FA level is correlated with the development of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, China.

ABSTRACT

Background: Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis.

Method: Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.

Results: Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD=1.36, 95%CI: 0.37-2.36, P=0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD=1.73, 95%CI: 0.20-3.26, P=0.026), but not in Asians (SMD=1.04, 95%CI: -0.33-2.40, P=0.138).

Conclusion: The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

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Related in: MedlinePlus

Subgroup analyses on the difference of serum fetuin-A levels between cardiovascular disease patients and healthy subjects.
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fig4: Subgroup analyses on the difference of serum fetuin-A levels between cardiovascular disease patients and healthy subjects.

Mentions: As shown in Figure 3, our meta-analysis revealed a positive association between low FA serum level and CVDs (SMD = 1.36, 95% CI: 0.37–2.36, P = 0.007). Subgroup analysis based on ethnicity implied that low FA serum levels may be the main risk factor for CVDs in Caucasian populations (SMD = 1.73, 95% CI: 0.20–3.26, P = 0.026), but not in Asian populations (SMD = 1.04, 95% CI: −0.33–2.40, P = 0.138) (as shown in Figure 4). Further subgroup analyses by sample size showed that FA serum levels were positively correlated with CVDs in both large sample (SMD = 1.51, 95% CI: 0.26–2.76, P = 0.018) and small sample subgroups (SMD = 1.07, 95% CI: 0.51–1.62, P < 0.001) (as shown in Figure 4).


Serum fetuin-A levels in patients with cardiovascular disease: a meta-analysis.

Sun ZL, Xie QY, Guo GL, Ma K, Huang YY - Biomed Res Int (2014)

Subgroup analyses on the difference of serum fetuin-A levels between cardiovascular disease patients and healthy subjects.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4216691&req=5

fig4: Subgroup analyses on the difference of serum fetuin-A levels between cardiovascular disease patients and healthy subjects.
Mentions: As shown in Figure 3, our meta-analysis revealed a positive association between low FA serum level and CVDs (SMD = 1.36, 95% CI: 0.37–2.36, P = 0.007). Subgroup analysis based on ethnicity implied that low FA serum levels may be the main risk factor for CVDs in Caucasian populations (SMD = 1.73, 95% CI: 0.20–3.26, P = 0.026), but not in Asian populations (SMD = 1.04, 95% CI: −0.33–2.40, P = 0.138) (as shown in Figure 4). Further subgroup analyses by sample size showed that FA serum levels were positively correlated with CVDs in both large sample (SMD = 1.51, 95% CI: 0.26–2.76, P = 0.018) and small sample subgroups (SMD = 1.07, 95% CI: 0.51–1.62, P < 0.001) (as shown in Figure 4).

Bottom Line: Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD=1.36, 95%CI: 0.37-2.36, P=0.007).The data indicated that decreased serum FA level is correlated with the development of CVDs.

View Article: PubMed Central - PubMed

Affiliation: Department of Cardiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, China.

ABSTRACT

Background: Fetuin-A (FA) suppresses arterial calcification, promotes insulin resistance, and appears to be elevated in patients with cardiovascular diseases (CVD), but the data is still inconsistent. To clarify the correlation between serum FA levels and the presence and severity of CVDs, we performed this meta-analysis.

Method: Potential relevant studies were identified covering the following databases: PubMed, Embase, Web of Science, Cochrane Library, CISCOM, CINAHL, Google Scholar, China BioMedicine (CBM), and China National Knowledge Infrastructure (CNKI) databases. Data from eligible studies were extracted and included in the meta-analysis using a random-effects model.

Results: Ten case-control studies, including 1,281 patients with CVDs and 2,663 healthy controls, were included. The results showed significant differences in serum levels of FA between the CVDs patients and the healthy controls (SMD=1.36, 95%CI: 0.37-2.36, P=0.007). Ethnicity-subgroup analysis implied that low serum FA levels are related to CVDs in Caucasians (SMD=1.73, 95%CI: 0.20-3.26, P=0.026), but not in Asians (SMD=1.04, 95%CI: -0.33-2.40, P=0.138).

Conclusion: The data indicated that decreased serum FA level is correlated with the development of CVDs. FA might be clinically valuable for reflecting the progression of CVDs.

Show MeSH
Related in: MedlinePlus