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The prevalence of increased serum IgE and Aspergillus sensitization in patients with COPD and their association with symptoms and lung function.

Jin J, Liu X, Sun Y - Respir. Res. (2014)

Bottom Line: Compared with the normal T-IgE group, patients with elevated T-IgE had a longer history of dyspnea (p < 0.01), an earlier onset of dyspnea after chronic cough/expectoration (p < 0.01), and were more likely to wheeze (p < 0.01).Analysis of the clinical data in male patients with smoking as the risk factor showed the same results.Correlation analysis demonstrated that T-IgE was correlated positively with the time length of dyspnea (r = 0.401, p < 0.001), and the ratio of duration of dyspnea to that of chronic cough/expectoration (r = 0.59, p < 0.001), but negatively with FEV1/FVC% (r = -0.194, p = 0.001), and FEV1%predicted (r = -0.219, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China. suny@ccmu.edu.cn.

ABSTRACT

Background: Allergy and Aspergillus hypersensitivity (AH) were shown to be associated with severe symptoms or worse lung function in COPD patients. The prevalence of elevated total IgE (T-IgE) and its association with clinical symptoms and lung function in COPD have not been studied. The prevalence of AH and its correlation with clinical characteristics in a COPD cohort of larger sample size is also lacking.

Methods: 273 patients with COPD were evaluated by respiratory symptoms, blood test, chest HRCT, lung function, serum detection of T-IgE and Aspergillus specific IgE. Patients with T-IgE ≥ 1000 KU/L were further investigated for allergic bronchopulmonary aspergillosis (ABPA).

Results: The prevalence of elevated T-IgE and AH in patients with COPD was 47.3% and 15.0%, respectively. Eight patients (2.9%) met the diagnostic criteria for ABPA. Compared with the normal T-IgE group, patients with elevated T-IgE had a longer history of dyspnea (p < 0.01), an earlier onset of dyspnea after chronic cough/expectoration (p < 0.01), and were more likely to wheeze (p < 0.01). They also showed worse lung functions and more severe GOLD staging (p < 0.01). Analysis of the clinical data in male patients with smoking as the risk factor showed the same results. To evaluate the clinical characteristics of COPD with AH, patients with elevated T-IgE were further divided into subgroups with and without AH. When compared with the normal T-IgE group, both the two subgroups showed longer history of dyspnea (p < 0.01), an earlier onset of dyspnea (p < 0.01) and a worse status of lung function (p < 0.05). Correlation analysis demonstrated that T-IgE was correlated positively with the time length of dyspnea (r = 0.401, p < 0.001), and the ratio of duration of dyspnea to that of chronic cough/expectoration (r = 0.59, p < 0.001), but negatively with FEV1/FVC% (r = -0.194, p = 0.001), and FEV1%predicted (r = -0.219, p < 0.001).

Conclusions: There was a high prevalence of elevated serum T-IgE and AH in patients with COPD. Serum T-IgE level was correlated with symptoms such as dyspnea and impairment of lung function. Allergens other than Aspergillus may have similar effects on disease expression or progression of COPD.

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Selection and diagnostic procedure of study subjects.Definition of abbreviations: HRCT: high resolution computed tomography, T-IgE: serum total IgE, A. Fumigatus: Aspergillus Fumigatus, AH: Aspergillus hypersensitivity, ABPA: Allergic bronchopulmonary aspergillosis.
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Fig1: Selection and diagnostic procedure of study subjects.Definition of abbreviations: HRCT: high resolution computed tomography, T-IgE: serum total IgE, A. Fumigatus: Aspergillus Fumigatus, AH: Aspergillus hypersensitivity, ABPA: Allergic bronchopulmonary aspergillosis.

Mentions: Patients with COPD visiting Beijing Tongren Hospital from July 2008 to July 2013 were enrolled. The subject selection and diagnostic process were shown in Figure 1. The study was approved by the local ethics committee of Beijing Tongren Hospital, Capital Medical University, and written informed consent was obtained from all patients.Figure 1


The prevalence of increased serum IgE and Aspergillus sensitization in patients with COPD and their association with symptoms and lung function.

Jin J, Liu X, Sun Y - Respir. Res. (2014)

Selection and diagnostic procedure of study subjects.Definition of abbreviations: HRCT: high resolution computed tomography, T-IgE: serum total IgE, A. Fumigatus: Aspergillus Fumigatus, AH: Aspergillus hypersensitivity, ABPA: Allergic bronchopulmonary aspergillosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC4216660&req=5

Fig1: Selection and diagnostic procedure of study subjects.Definition of abbreviations: HRCT: high resolution computed tomography, T-IgE: serum total IgE, A. Fumigatus: Aspergillus Fumigatus, AH: Aspergillus hypersensitivity, ABPA: Allergic bronchopulmonary aspergillosis.
Mentions: Patients with COPD visiting Beijing Tongren Hospital from July 2008 to July 2013 were enrolled. The subject selection and diagnostic process were shown in Figure 1. The study was approved by the local ethics committee of Beijing Tongren Hospital, Capital Medical University, and written informed consent was obtained from all patients.Figure 1

Bottom Line: Compared with the normal T-IgE group, patients with elevated T-IgE had a longer history of dyspnea (p < 0.01), an earlier onset of dyspnea after chronic cough/expectoration (p < 0.01), and were more likely to wheeze (p < 0.01).Analysis of the clinical data in male patients with smoking as the risk factor showed the same results.Correlation analysis demonstrated that T-IgE was correlated positively with the time length of dyspnea (r = 0.401, p < 0.001), and the ratio of duration of dyspnea to that of chronic cough/expectoration (r = 0.59, p < 0.001), but negatively with FEV1/FVC% (r = -0.194, p = 0.001), and FEV1%predicted (r = -0.219, p < 0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China. suny@ccmu.edu.cn.

ABSTRACT

Background: Allergy and Aspergillus hypersensitivity (AH) were shown to be associated with severe symptoms or worse lung function in COPD patients. The prevalence of elevated total IgE (T-IgE) and its association with clinical symptoms and lung function in COPD have not been studied. The prevalence of AH and its correlation with clinical characteristics in a COPD cohort of larger sample size is also lacking.

Methods: 273 patients with COPD were evaluated by respiratory symptoms, blood test, chest HRCT, lung function, serum detection of T-IgE and Aspergillus specific IgE. Patients with T-IgE ≥ 1000 KU/L were further investigated for allergic bronchopulmonary aspergillosis (ABPA).

Results: The prevalence of elevated T-IgE and AH in patients with COPD was 47.3% and 15.0%, respectively. Eight patients (2.9%) met the diagnostic criteria for ABPA. Compared with the normal T-IgE group, patients with elevated T-IgE had a longer history of dyspnea (p < 0.01), an earlier onset of dyspnea after chronic cough/expectoration (p < 0.01), and were more likely to wheeze (p < 0.01). They also showed worse lung functions and more severe GOLD staging (p < 0.01). Analysis of the clinical data in male patients with smoking as the risk factor showed the same results. To evaluate the clinical characteristics of COPD with AH, patients with elevated T-IgE were further divided into subgroups with and without AH. When compared with the normal T-IgE group, both the two subgroups showed longer history of dyspnea (p < 0.01), an earlier onset of dyspnea (p < 0.01) and a worse status of lung function (p < 0.05). Correlation analysis demonstrated that T-IgE was correlated positively with the time length of dyspnea (r = 0.401, p < 0.001), and the ratio of duration of dyspnea to that of chronic cough/expectoration (r = 0.59, p < 0.001), but negatively with FEV1/FVC% (r = -0.194, p = 0.001), and FEV1%predicted (r = -0.219, p < 0.001).

Conclusions: There was a high prevalence of elevated serum T-IgE and AH in patients with COPD. Serum T-IgE level was correlated with symptoms such as dyspnea and impairment of lung function. Allergens other than Aspergillus may have similar effects on disease expression or progression of COPD.

Show MeSH
Related in: MedlinePlus