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Disseminated mucormycosis in a paediatric patient: Lichthemia corymbifera successfully treated with combination antifungal therapy.

Campbell A, Cooper C, Davis S - Med Mycol Case Rep (2014)

Bottom Line: It carries a high morbidity and mortality rate and is characterised by extensive angioinvasion and necrosis of host tissue.This case report details success in treating disseminated mucormycosis in a paediatric patient with an underlying haematological malignancy.Treatment included institution of combination antifungal therapy with liposomal amphotericin B and caspofungin, aggressive surgical debridement of infected tissue and reversal of underlying immunosuppression.

View Article: PubMed Central - PubMed

Affiliation: Women׳s and Children׳s Hospital: Infectious Diseases and Microbiology Department, 72 King William Road, North Adelaide 5006, Australia.

ABSTRACT
Mucormycosis is a severe fungal infection that largely affects immunocompromised individuals. It carries a high morbidity and mortality rate and is characterised by extensive angioinvasion and necrosis of host tissue. This case report details success in treating disseminated mucormycosis in a paediatric patient with an underlying haematological malignancy. Treatment included institution of combination antifungal therapy with liposomal amphotericin B and caspofungin, aggressive surgical debridement of infected tissue and reversal of underlying immunosuppression.

No MeSH data available.


Related in: MedlinePlus

MRI of the abdomen shows a non-enhancing lesion centrally in the medial aspect of the mid-pole of the right kidney.
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f0020: MRI of the abdomen shows a non-enhancing lesion centrally in the medial aspect of the mid-pole of the right kidney.

Mentions: On day 7, repeat imaging revealed further lesions in the medial aspect of the right kidney (Fig. 4) and in the left occipital lobe of the brain (Fig. 5), as well as rapid growth of the preexisting lesions in the lung and pancreas. On day 11, combination antifungal therapy was initiated, with the addition of caspofungin, at a loading dose of 70 mg/m2/day, continuing at 50 mg/m2/day and L-AMB was continued at a higher dose of 10 mg/kg/day.


Disseminated mucormycosis in a paediatric patient: Lichthemia corymbifera successfully treated with combination antifungal therapy.

Campbell A, Cooper C, Davis S - Med Mycol Case Rep (2014)

MRI of the abdomen shows a non-enhancing lesion centrally in the medial aspect of the mid-pole of the right kidney.
© Copyright Policy - CC BY-NC-ND
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4216331&req=5

f0020: MRI of the abdomen shows a non-enhancing lesion centrally in the medial aspect of the mid-pole of the right kidney.
Mentions: On day 7, repeat imaging revealed further lesions in the medial aspect of the right kidney (Fig. 4) and in the left occipital lobe of the brain (Fig. 5), as well as rapid growth of the preexisting lesions in the lung and pancreas. On day 11, combination antifungal therapy was initiated, with the addition of caspofungin, at a loading dose of 70 mg/m2/day, continuing at 50 mg/m2/day and L-AMB was continued at a higher dose of 10 mg/kg/day.

Bottom Line: It carries a high morbidity and mortality rate and is characterised by extensive angioinvasion and necrosis of host tissue.This case report details success in treating disseminated mucormycosis in a paediatric patient with an underlying haematological malignancy.Treatment included institution of combination antifungal therapy with liposomal amphotericin B and caspofungin, aggressive surgical debridement of infected tissue and reversal of underlying immunosuppression.

View Article: PubMed Central - PubMed

Affiliation: Women׳s and Children׳s Hospital: Infectious Diseases and Microbiology Department, 72 King William Road, North Adelaide 5006, Australia.

ABSTRACT
Mucormycosis is a severe fungal infection that largely affects immunocompromised individuals. It carries a high morbidity and mortality rate and is characterised by extensive angioinvasion and necrosis of host tissue. This case report details success in treating disseminated mucormycosis in a paediatric patient with an underlying haematological malignancy. Treatment included institution of combination antifungal therapy with liposomal amphotericin B and caspofungin, aggressive surgical debridement of infected tissue and reversal of underlying immunosuppression.

No MeSH data available.


Related in: MedlinePlus