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Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.

Lu Y, Gao J, Lu Y - Onco Targets Ther (2014)

Bottom Line: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.Downregulated Ku70 and ATM were associated with poor disease-free survival.Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, School of Public Health, Guilin Medical University, Guangxi, People's Republic of China ; Department of Clinical Research Center, Affiliated 2nd Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT

Background: Double-strand DNA breaks (DSBs) are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal in maintaining normal cell division. To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia-telangiectasia mutated (ATM) in colorectal cancer (CRC), we examined the expression levels and patterns of Ku70 and ATM in CRC samples.

Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients.

Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.

Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.

No MeSH data available.


Related in: MedlinePlus

Expression of Ku70 and ATM correlated with poor prognosis in colorectal cancer patients.Notes: (A) Cumulative overall survival between the Ku70-negative and Ku70-positive group (P<0.001, log-rank test). (B) Cumulative overall survival between the ATM-negative and ATM-positive group (P<0.001, log-rank test).Abbreviations: ATM, ataxia-telangiectasia mutated; mo, months.
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f2-ott-7-1955: Expression of Ku70 and ATM correlated with poor prognosis in colorectal cancer patients.Notes: (A) Cumulative overall survival between the Ku70-negative and Ku70-positive group (P<0.001, log-rank test). (B) Cumulative overall survival between the ATM-negative and ATM-positive group (P<0.001, log-rank test).Abbreviations: ATM, ataxia-telangiectasia mutated; mo, months.

Mentions: Furthermore, we found that patients whose CRC specimens were negative for Ku70 or ATM had poorer prognoses than those with Ku70+/ATM+ CRC (Figure 2). The 5-year estimated probability of cumulative survival rate also differed between the patient groups with Ku70− or ATM− CRC and the Ku70+ or ATM+ group (P<0.05). Univariate analyses results showed that LNM, TNM stage, Ku70, and ATM expression resulted in the overall survival. In multivariate analysis, LNM, TNM stage, Ku70, and ATM expression were correlated to the overall survival (P<0.05, Table 2).


Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.

Lu Y, Gao J, Lu Y - Onco Targets Ther (2014)

Expression of Ku70 and ATM correlated with poor prognosis in colorectal cancer patients.Notes: (A) Cumulative overall survival between the Ku70-negative and Ku70-positive group (P<0.001, log-rank test). (B) Cumulative overall survival between the ATM-negative and ATM-positive group (P<0.001, log-rank test).Abbreviations: ATM, ataxia-telangiectasia mutated; mo, months.
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Related In: Results  -  Collection

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getmorefigures.php?uid=PMC4216044&req=5

f2-ott-7-1955: Expression of Ku70 and ATM correlated with poor prognosis in colorectal cancer patients.Notes: (A) Cumulative overall survival between the Ku70-negative and Ku70-positive group (P<0.001, log-rank test). (B) Cumulative overall survival between the ATM-negative and ATM-positive group (P<0.001, log-rank test).Abbreviations: ATM, ataxia-telangiectasia mutated; mo, months.
Mentions: Furthermore, we found that patients whose CRC specimens were negative for Ku70 or ATM had poorer prognoses than those with Ku70+/ATM+ CRC (Figure 2). The 5-year estimated probability of cumulative survival rate also differed between the patient groups with Ku70− or ATM− CRC and the Ku70+ or ATM+ group (P<0.05). Univariate analyses results showed that LNM, TNM stage, Ku70, and ATM expression resulted in the overall survival. In multivariate analysis, LNM, TNM stage, Ku70, and ATM expression were correlated to the overall survival (P<0.05, Table 2).

Bottom Line: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.Downregulated Ku70 and ATM were associated with poor disease-free survival.Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.

View Article: PubMed Central - PubMed

Affiliation: Department of Toxicology, School of Public Health, Guilin Medical University, Guangxi, People's Republic of China ; Department of Clinical Research Center, Affiliated 2nd Hospital of Nanjing Medical University, Nanjing, People's Republic of China.

ABSTRACT

Background: Double-strand DNA breaks (DSBs) are a key factor in carcinogenesis. The necessary repair of DSBs is pivotal in maintaining normal cell division. To address the relationship between altered expression of DSB repair of proteins Ku70 and ataxia-telangiectasia mutated (ATM) in colorectal cancer (CRC), we examined the expression levels and patterns of Ku70 and ATM in CRC samples.

Methods: Expression and coexpression of Ku70 and ATM were investigated by using real-time quantitative polymerase chain reaction assays and confirmed further with fluorescent immunohistochemistry in CRC and pericancerous samples from 112 Chinese patients.

Results: Downexpression patterns for both Ku70 and ATM were found in the CRC samples and were significantly associated with advanced tumor node metastasis stage and decreased 5-year overall survival rate.

Conclusion: Downregulated Ku70 and ATM were associated with poor disease-free survival. Loss of Ku70 and ATM expression might act as a biomarker to predict poor prognosis in patients with CRC.

No MeSH data available.


Related in: MedlinePlus