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Epidemiology of hepatitis E virus in China: results from the Third National Viral Hepatitis Prevalence Survey, 2005-2006.

Jia Z, Yi Y, Liu J, Cao J, Zhang Y, Tian R, Yu T, Wang H, Wang X, Su Q, Zhou W, Cui F, Liang X, Bi S - PLoS ONE (2014)

Bottom Line: The results were analyzed to calculate estimates of HEV seroprevalence and to examine the effects of some putative risk factors.The characteristics of the distribution associated may be due to the route of HEV transmission (via contaminated water or animal reservoirs).Within the same region, the seroprevalence of HEV is generally increased with age.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

ABSTRACT
In China, hepatitis E virus (HEV) is prevalent and causes disease, but its epidemiological profile is not well understood. We used a commercial enzyme-linked immunosorbent assay to detect total antibodies to hepatitis E virus in 15,862 serum samples collected during the Third National Viral Hepatitis Prevalence Survey. The results were analyzed to calculate estimates of HEV seroprevalence and to examine the effects of some putative risk factors. The seroprevalence of HEV in the general Chinese population during the period from 2005 through 2006 was 23.46% (95% confidence interval [CI], 18.41%-28.50%). The farming population, the age group of 15-60 year olds, and those living in the Midwest or Mideast region and in Xinjiang province had the highest seroprevalence estimates. The prevalence of HEV is high in China. The seroprevalence rate of HEV shows an unbalanced distribution among areas with different geographic location and economic development levels. The characteristics of the distribution associated may be due to the route of HEV transmission (via contaminated water or animal reservoirs). Within the same region, the seroprevalence of HEV is generally increased with age.

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Adjusted seroprevalence of HEV antibodies in the Chinese population by province.
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pone-0110837-g002: Adjusted seroprevalence of HEV antibodies in the Chinese population by province.

Mentions: Seven provinces (Sichuan, Guizhou, Yunnan, Xinjiang, Shanghai, Hubei and Jiangsu) had the highest seroprevalence estimates in China. Nine provinces (Gansu, Zhejiang, Henan, etc.) had intermediate estimates and the other provinces had lower HEV seroprevalence estimates (Figure 2).


Epidemiology of hepatitis E virus in China: results from the Third National Viral Hepatitis Prevalence Survey, 2005-2006.

Jia Z, Yi Y, Liu J, Cao J, Zhang Y, Tian R, Yu T, Wang H, Wang X, Su Q, Zhou W, Cui F, Liang X, Bi S - PLoS ONE (2014)

Adjusted seroprevalence of HEV antibodies in the Chinese population by province.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215996&req=5

pone-0110837-g002: Adjusted seroprevalence of HEV antibodies in the Chinese population by province.
Mentions: Seven provinces (Sichuan, Guizhou, Yunnan, Xinjiang, Shanghai, Hubei and Jiangsu) had the highest seroprevalence estimates in China. Nine provinces (Gansu, Zhejiang, Henan, etc.) had intermediate estimates and the other provinces had lower HEV seroprevalence estimates (Figure 2).

Bottom Line: The results were analyzed to calculate estimates of HEV seroprevalence and to examine the effects of some putative risk factors.The characteristics of the distribution associated may be due to the route of HEV transmission (via contaminated water or animal reservoirs).Within the same region, the seroprevalence of HEV is generally increased with age.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

ABSTRACT
In China, hepatitis E virus (HEV) is prevalent and causes disease, but its epidemiological profile is not well understood. We used a commercial enzyme-linked immunosorbent assay to detect total antibodies to hepatitis E virus in 15,862 serum samples collected during the Third National Viral Hepatitis Prevalence Survey. The results were analyzed to calculate estimates of HEV seroprevalence and to examine the effects of some putative risk factors. The seroprevalence of HEV in the general Chinese population during the period from 2005 through 2006 was 23.46% (95% confidence interval [CI], 18.41%-28.50%). The farming population, the age group of 15-60 year olds, and those living in the Midwest or Mideast region and in Xinjiang province had the highest seroprevalence estimates. The prevalence of HEV is high in China. The seroprevalence rate of HEV shows an unbalanced distribution among areas with different geographic location and economic development levels. The characteristics of the distribution associated may be due to the route of HEV transmission (via contaminated water or animal reservoirs). Within the same region, the seroprevalence of HEV is generally increased with age.

Show MeSH
Related in: MedlinePlus