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Bacterial etiologies of five core syndromes: laboratory-based syndromic surveillance conducted in Guangxi, China.

Dong B, Liang D, Lin M, Wang M, Zeng J, Liao H, Zhou L, Huang J, Wei X, Zou G, Jing H - PLoS ONE (2014)

Bottom Line: To date no pathogen was isolated from the specimens from fever and hemorrhage patients.In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention.Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Response, Guagnxi Zhuang Autonomous Region Health Bureau, Nanning, Guangxi, China.

ABSTRACT

Background: Under the existing national surveillance system in China for selected infectious diseases, bacterial cultures are performed for only a small percentage of reported cases. We set up a laboratory-based syndromic surveillance system to elucidate bacterial etiologic spectrum and detect infection by rare etiologies (or serogroups) for five core syndromes in the given study area.

Methods: Patients presenting with one of five core syndromes at nine sentinel hospitals in Guagnxi, China were evaluated using laboratory-based syndrome surveillance to elucidate bacterial etiologies. We collected respiratory and stool specimens, as well as CSF, blood and other related samples for bacterial cultures and pulse field gel electrophoresis (PFGE) assays.

Results: From February 2009 to December 2011, 2,964 patients were enrolled in the study. Etiologies were identified in 320 (10.08%) patients. Streptococcus pneumonia (37 strains, 24.18%), Klebsiella pneumonia (34, 22.22%), Pseudomonas aeruginosa (19, 12.42%) and Haemophilus influenza (18, 11.76%) were the most frequent pathogens for fever and respiratory syndrome, while Salmonella (77, 81.05%) was most often seen in diarrhea syndrome cases. Salmonella paratyphi A (38, 86.36%) occurred in fever and rash syndrome, with Cryptococcus neoformans (20, 35.09%), Streptococcus pneumonia (5, 8.77%), Klebsiella pneumonia (5, 8.77%),streptococcus suis (3, 5.26%) and Neisseria meningitides group B (2, 3.51%) being the most frequently detected in encephalitis-meningitis syndrome. To date no pathogen was isolated from the specimens from fever and hemorrhage patients.

Conclusions: In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention. Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

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Related in: MedlinePlus

Comparison of PFGE patterns for isolates with high similarity.
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pone-0110876-g006: Comparison of PFGE patterns for isolates with high similarity.

Mentions: A total of 112 strains of Salmonella were isolated in this surveillance system, making it the most commonly detected bacterial pathogen at present. PFGE assays indicated that these 112 Salmonella isolates were clustered in several pulsotypes. Figure 6 shows that identical PFGE patterns were observed in WD046 and WD078, WD020 and WD093, WD053 and WD084, WD011 and WD086, WD047 and WD101, (WD013, 058, 072, 082) and WD103, WD074 and WD075, WD069 and WD097.


Bacterial etiologies of five core syndromes: laboratory-based syndromic surveillance conducted in Guangxi, China.

Dong B, Liang D, Lin M, Wang M, Zeng J, Liao H, Zhou L, Huang J, Wei X, Zou G, Jing H - PLoS ONE (2014)

Comparison of PFGE patterns for isolates with high similarity.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215986&req=5

pone-0110876-g006: Comparison of PFGE patterns for isolates with high similarity.
Mentions: A total of 112 strains of Salmonella were isolated in this surveillance system, making it the most commonly detected bacterial pathogen at present. PFGE assays indicated that these 112 Salmonella isolates were clustered in several pulsotypes. Figure 6 shows that identical PFGE patterns were observed in WD046 and WD078, WD020 and WD093, WD053 and WD084, WD011 and WD086, WD047 and WD101, (WD013, 058, 072, 082) and WD103, WD074 and WD075, WD069 and WD097.

Bottom Line: To date no pathogen was isolated from the specimens from fever and hemorrhage patients.In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention.Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Response, Guagnxi Zhuang Autonomous Region Health Bureau, Nanning, Guangxi, China.

ABSTRACT

Background: Under the existing national surveillance system in China for selected infectious diseases, bacterial cultures are performed for only a small percentage of reported cases. We set up a laboratory-based syndromic surveillance system to elucidate bacterial etiologic spectrum and detect infection by rare etiologies (or serogroups) for five core syndromes in the given study area.

Methods: Patients presenting with one of five core syndromes at nine sentinel hospitals in Guagnxi, China were evaluated using laboratory-based syndrome surveillance to elucidate bacterial etiologies. We collected respiratory and stool specimens, as well as CSF, blood and other related samples for bacterial cultures and pulse field gel electrophoresis (PFGE) assays.

Results: From February 2009 to December 2011, 2,964 patients were enrolled in the study. Etiologies were identified in 320 (10.08%) patients. Streptococcus pneumonia (37 strains, 24.18%), Klebsiella pneumonia (34, 22.22%), Pseudomonas aeruginosa (19, 12.42%) and Haemophilus influenza (18, 11.76%) were the most frequent pathogens for fever and respiratory syndrome, while Salmonella (77, 81.05%) was most often seen in diarrhea syndrome cases. Salmonella paratyphi A (38, 86.36%) occurred in fever and rash syndrome, with Cryptococcus neoformans (20, 35.09%), Streptococcus pneumonia (5, 8.77%), Klebsiella pneumonia (5, 8.77%),streptococcus suis (3, 5.26%) and Neisseria meningitides group B (2, 3.51%) being the most frequently detected in encephalitis-meningitis syndrome. To date no pathogen was isolated from the specimens from fever and hemorrhage patients.

Conclusions: In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention. Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

Show MeSH
Related in: MedlinePlus