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Bacterial etiologies of five core syndromes: laboratory-based syndromic surveillance conducted in Guangxi, China.

Dong B, Liang D, Lin M, Wang M, Zeng J, Liao H, Zhou L, Huang J, Wei X, Zou G, Jing H - PLoS ONE (2014)

Bottom Line: To date no pathogen was isolated from the specimens from fever and hemorrhage patients.In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention.Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Response, Guagnxi Zhuang Autonomous Region Health Bureau, Nanning, Guangxi, China.

ABSTRACT

Background: Under the existing national surveillance system in China for selected infectious diseases, bacterial cultures are performed for only a small percentage of reported cases. We set up a laboratory-based syndromic surveillance system to elucidate bacterial etiologic spectrum and detect infection by rare etiologies (or serogroups) for five core syndromes in the given study area.

Methods: Patients presenting with one of five core syndromes at nine sentinel hospitals in Guagnxi, China were evaluated using laboratory-based syndrome surveillance to elucidate bacterial etiologies. We collected respiratory and stool specimens, as well as CSF, blood and other related samples for bacterial cultures and pulse field gel electrophoresis (PFGE) assays.

Results: From February 2009 to December 2011, 2,964 patients were enrolled in the study. Etiologies were identified in 320 (10.08%) patients. Streptococcus pneumonia (37 strains, 24.18%), Klebsiella pneumonia (34, 22.22%), Pseudomonas aeruginosa (19, 12.42%) and Haemophilus influenza (18, 11.76%) were the most frequent pathogens for fever and respiratory syndrome, while Salmonella (77, 81.05%) was most often seen in diarrhea syndrome cases. Salmonella paratyphi A (38, 86.36%) occurred in fever and rash syndrome, with Cryptococcus neoformans (20, 35.09%), Streptococcus pneumonia (5, 8.77%), Klebsiella pneumonia (5, 8.77%),streptococcus suis (3, 5.26%) and Neisseria meningitides group B (2, 3.51%) being the most frequently detected in encephalitis-meningitis syndrome. To date no pathogen was isolated from the specimens from fever and hemorrhage patients.

Conclusions: In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention. Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

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Etiological distribution of diarrhea syndrome in Guangxi, China, 2009–2011.Of 95 etiologies cultured from specimens of diarrhea syndromes: Salmonella(Sa,77), Salmonella-typhi(Sat,1), Pathogenic Escherichia coli(PE,3), Enterotoxigenic Escherichia coli(ETEC,1), Campylobacter jejuni(CJ,3), Yersinia enterocolitica (YE,1), Yersinia pseudotuberculosis(YP,2), Plesiomonas shigelloides(PS,1), Aeromonas(Ae,6).
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pone-0110876-g003: Etiological distribution of diarrhea syndrome in Guangxi, China, 2009–2011.Of 95 etiologies cultured from specimens of diarrhea syndromes: Salmonella(Sa,77), Salmonella-typhi(Sat,1), Pathogenic Escherichia coli(PE,3), Enterotoxigenic Escherichia coli(ETEC,1), Campylobacter jejuni(CJ,3), Yersinia enterocolitica (YE,1), Yersinia pseudotuberculosis(YP,2), Plesiomonas shigelloides(PS,1), Aeromonas(Ae,6).

Mentions: Of 95 (27.22%) pathogens isolated from diarrhea syndrome specimens, pathogenic bacteria and opportunistic pathogens accounted for 90.53% and 9.47%, respectively. The most frequently isolated pathogens were non-typhoidal Salmonella (77, 81.05%), Aeromonas (6, 6.32%), Pathogenic Escherichia coli (6, 6.32%),and Campylobacter jejuni (3, 3.16%) (Figure 3).


Bacterial etiologies of five core syndromes: laboratory-based syndromic surveillance conducted in Guangxi, China.

Dong B, Liang D, Lin M, Wang M, Zeng J, Liao H, Zhou L, Huang J, Wei X, Zou G, Jing H - PLoS ONE (2014)

Etiological distribution of diarrhea syndrome in Guangxi, China, 2009–2011.Of 95 etiologies cultured from specimens of diarrhea syndromes: Salmonella(Sa,77), Salmonella-typhi(Sat,1), Pathogenic Escherichia coli(PE,3), Enterotoxigenic Escherichia coli(ETEC,1), Campylobacter jejuni(CJ,3), Yersinia enterocolitica (YE,1), Yersinia pseudotuberculosis(YP,2), Plesiomonas shigelloides(PS,1), Aeromonas(Ae,6).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215986&req=5

pone-0110876-g003: Etiological distribution of diarrhea syndrome in Guangxi, China, 2009–2011.Of 95 etiologies cultured from specimens of diarrhea syndromes: Salmonella(Sa,77), Salmonella-typhi(Sat,1), Pathogenic Escherichia coli(PE,3), Enterotoxigenic Escherichia coli(ETEC,1), Campylobacter jejuni(CJ,3), Yersinia enterocolitica (YE,1), Yersinia pseudotuberculosis(YP,2), Plesiomonas shigelloides(PS,1), Aeromonas(Ae,6).
Mentions: Of 95 (27.22%) pathogens isolated from diarrhea syndrome specimens, pathogenic bacteria and opportunistic pathogens accounted for 90.53% and 9.47%, respectively. The most frequently isolated pathogens were non-typhoidal Salmonella (77, 81.05%), Aeromonas (6, 6.32%), Pathogenic Escherichia coli (6, 6.32%),and Campylobacter jejuni (3, 3.16%) (Figure 3).

Bottom Line: To date no pathogen was isolated from the specimens from fever and hemorrhage patients.In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention.Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

View Article: PubMed Central - PubMed

Affiliation: Department of Emergency Response, Guagnxi Zhuang Autonomous Region Health Bureau, Nanning, Guangxi, China.

ABSTRACT

Background: Under the existing national surveillance system in China for selected infectious diseases, bacterial cultures are performed for only a small percentage of reported cases. We set up a laboratory-based syndromic surveillance system to elucidate bacterial etiologic spectrum and detect infection by rare etiologies (or serogroups) for five core syndromes in the given study area.

Methods: Patients presenting with one of five core syndromes at nine sentinel hospitals in Guagnxi, China were evaluated using laboratory-based syndrome surveillance to elucidate bacterial etiologies. We collected respiratory and stool specimens, as well as CSF, blood and other related samples for bacterial cultures and pulse field gel electrophoresis (PFGE) assays.

Results: From February 2009 to December 2011, 2,964 patients were enrolled in the study. Etiologies were identified in 320 (10.08%) patients. Streptococcus pneumonia (37 strains, 24.18%), Klebsiella pneumonia (34, 22.22%), Pseudomonas aeruginosa (19, 12.42%) and Haemophilus influenza (18, 11.76%) were the most frequent pathogens for fever and respiratory syndrome, while Salmonella (77, 81.05%) was most often seen in diarrhea syndrome cases. Salmonella paratyphi A (38, 86.36%) occurred in fever and rash syndrome, with Cryptococcus neoformans (20, 35.09%), Streptococcus pneumonia (5, 8.77%), Klebsiella pneumonia (5, 8.77%),streptococcus suis (3, 5.26%) and Neisseria meningitides group B (2, 3.51%) being the most frequently detected in encephalitis-meningitis syndrome. To date no pathogen was isolated from the specimens from fever and hemorrhage patients.

Conclusions: In addition to common bacterial pathogens, opportunistic pathogens and fungal infections require more attention. Our study contributes to the strengthening of the existing national surveillance system and provides references for other regions that are similar to the study area.

Show MeSH
Related in: MedlinePlus