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Detection of human papillomavirus type 39 in a seborrheic inclusion cyst of the buttock.

Song DH, Lee SG, Kim DC, Lee JH, Ko GH, Lee JS - Korean J Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, The Armed Forces Capital Hospital, Seongnam, Korea.

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A seborrheic inclusion cyst (SIC) is a lesion, which has been described as a combination of seborrheic keratosis and an epidermoid cyst (EC)... However, no SIC study has ever used HPV genotyping... Herein, we report the first case of SIC associated with HPV type 39, which we identified using the HPV DNA chip... In addition, squamous eddies, vacuolated cells and parakeratosis were observed in the cyst wall (Fig. 1C)... No significant area of inflammation as might be present in a foreign body reaction was observed in the adjacent soft tissue... Although few data have been published in regards to SIC with HPV, ECs of cutaneous cysts have been relatively well studied in regards to HPV infection... Kim et al. identified the high-risk HPV type 59 in a verrucous cyst of the flank and suggested that closer attention will be needed to characterize the clinical behavior associated with that type of cyst... Therefore, further studies will be required in order to determine the clinical implications of skin lesions associated with high-risk HPV infection... Park et al. described the development of EC in weight-bearing surfaces using three stages: first, a pre-existing wart is implanted into the dermis by weight; second, the implanted portion forms a cyst in the dermis... This theory was also supported by the association of nongenital seborrheic keratosis with HPV infection, which was described by Tardío et al.... In conclusion, we report a case of SIC associated with HPV type 39, which we identified using DNA chip analysis... This is the first report of successful HPV genotyping associated with SIC.

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Related in: MedlinePlus

Microscopic observation of a seborrheic inclusion cyst (SIC). (A) Low-power view of the SIC reveals an acanthotic cyst wall in the dermis. (B) Half of the cystic wall exhibits basaloid cell proliferation and pseudohorn cysts. (C) Parakeratosis and many vacuolated cells are visible in most areas of the cyst wall. (D) The other half of the cystic wall shows features of dermoid cysts and is lined by mature squamous cells with a granular layer; there are also several scattered foci of small clusters of sebaceous gland cells.
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f1-kjpathol-48-5-398: Microscopic observation of a seborrheic inclusion cyst (SIC). (A) Low-power view of the SIC reveals an acanthotic cyst wall in the dermis. (B) Half of the cystic wall exhibits basaloid cell proliferation and pseudohorn cysts. (C) Parakeratosis and many vacuolated cells are visible in most areas of the cyst wall. (D) The other half of the cystic wall shows features of dermoid cysts and is lined by mature squamous cells with a granular layer; there are also several scattered foci of small clusters of sebaceous gland cells.

Mentions: A 21-year-old Korean man presenting with a subcutaneous mass in the left buttock was admitted to the Armed Forces Capital Hospital. An excisional biopsy of the lesion was performed, and gross examination of skin tissue revealed a 2 cm unilocular cyst that was filled with a soft, yellow substance. Microscopic examination of the lesion identified a cyst containing keratins (Fig. 1A). Approximately one half of the cyst exhibited features of a dermoid cyst with a mature squamous epithelium with granular layers and small clusters of sebaceous cells (Fig. 1D), while the other half demonstrated basaloid cell proliferation and pseudohorn cysts (Fig. 1B). In addition, squamous eddies, vacuolated cells and parakeratosis were observed in the cyst wall (Fig. 1C). No significant area of inflammation as might be present in a foreign body reaction was observed in the adjacent soft tissue. There was also no evidence of viral infection, such as vacuolated cells or parakeratosis, at the skin surface.


Detection of human papillomavirus type 39 in a seborrheic inclusion cyst of the buttock.

Song DH, Lee SG, Kim DC, Lee JH, Ko GH, Lee JS - Korean J Pathol (2014)

Microscopic observation of a seborrheic inclusion cyst (SIC). (A) Low-power view of the SIC reveals an acanthotic cyst wall in the dermis. (B) Half of the cystic wall exhibits basaloid cell proliferation and pseudohorn cysts. (C) Parakeratosis and many vacuolated cells are visible in most areas of the cyst wall. (D) The other half of the cystic wall shows features of dermoid cysts and is lined by mature squamous cells with a granular layer; there are also several scattered foci of small clusters of sebaceous gland cells.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215970&req=5

f1-kjpathol-48-5-398: Microscopic observation of a seborrheic inclusion cyst (SIC). (A) Low-power view of the SIC reveals an acanthotic cyst wall in the dermis. (B) Half of the cystic wall exhibits basaloid cell proliferation and pseudohorn cysts. (C) Parakeratosis and many vacuolated cells are visible in most areas of the cyst wall. (D) The other half of the cystic wall shows features of dermoid cysts and is lined by mature squamous cells with a granular layer; there are also several scattered foci of small clusters of sebaceous gland cells.
Mentions: A 21-year-old Korean man presenting with a subcutaneous mass in the left buttock was admitted to the Armed Forces Capital Hospital. An excisional biopsy of the lesion was performed, and gross examination of skin tissue revealed a 2 cm unilocular cyst that was filled with a soft, yellow substance. Microscopic examination of the lesion identified a cyst containing keratins (Fig. 1A). Approximately one half of the cyst exhibited features of a dermoid cyst with a mature squamous epithelium with granular layers and small clusters of sebaceous cells (Fig. 1D), while the other half demonstrated basaloid cell proliferation and pseudohorn cysts (Fig. 1B). In addition, squamous eddies, vacuolated cells and parakeratosis were observed in the cyst wall (Fig. 1C). No significant area of inflammation as might be present in a foreign body reaction was observed in the adjacent soft tissue. There was also no evidence of viral infection, such as vacuolated cells or parakeratosis, at the skin surface.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, The Armed Forces Capital Hospital, Seongnam, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

A seborrheic inclusion cyst (SIC) is a lesion, which has been described as a combination of seborrheic keratosis and an epidermoid cyst (EC)... However, no SIC study has ever used HPV genotyping... Herein, we report the first case of SIC associated with HPV type 39, which we identified using the HPV DNA chip... In addition, squamous eddies, vacuolated cells and parakeratosis were observed in the cyst wall (Fig. 1C)... No significant area of inflammation as might be present in a foreign body reaction was observed in the adjacent soft tissue... Although few data have been published in regards to SIC with HPV, ECs of cutaneous cysts have been relatively well studied in regards to HPV infection... Kim et al. identified the high-risk HPV type 59 in a verrucous cyst of the flank and suggested that closer attention will be needed to characterize the clinical behavior associated with that type of cyst... Therefore, further studies will be required in order to determine the clinical implications of skin lesions associated with high-risk HPV infection... Park et al. described the development of EC in weight-bearing surfaces using three stages: first, a pre-existing wart is implanted into the dermis by weight; second, the implanted portion forms a cyst in the dermis... This theory was also supported by the association of nongenital seborrheic keratosis with HPV infection, which was described by Tardío et al.... In conclusion, we report a case of SIC associated with HPV type 39, which we identified using DNA chip analysis... This is the first report of successful HPV genotyping associated with SIC.

No MeSH data available.


Related in: MedlinePlus