Limits...
Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature.

Kim M, Park MI, Lim M, Kim J - Korean J Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Chungnam National University Hospital, Daejeon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification for cutaneous lymphomas describes three types of cutaneous lymphomas that express CD56: 1) subcutaneous panniculitis-like T-cell lymphoma, 2) extranodal natural killer (NK)/T-cell lymphoma, nasal type, and 3) CD4+/CD56+ hematodermic neoplasm (blastic NKcell lymphoma)... However, the report does not mention, MF with CD56 expression... The lesions appeared first on the buttock and thigh, and lately on the upper arm... The skin lesions did not respond to topical corticosteroid treatment, at which time, he visited our hospital... Laboratory blood tests revealed an elevated, total cholesterol level of 235 mg/dL (range, 125 to 220 mg/mL)... Complete blood cell count and other results of blood chemistry were within the normal range... The patient was diagnosed as having the stage IB, CD8+, CD56+ cytotoxic immunophenotype variant MF... None of the cases, including our case, had an aggressive clinical course... This result suggests that CD56+ MF is a disease with good prognosis similar to classic MF... Several reports of MF with CD8+ and/or CD56+ expression have suggested that this variant would have no prognostic difference compared with classic MF... In our case, with the observed immunophenotype, we considered different diagnoses including primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, primary cutaneous gamma/delta T-cell lymphoma, and extranodal NK/T-cell lymphoma, nasal type... In conclusion, we present a case of a cytotoxic variant of MF with a CD8+, CD56+ immunophenotype... We emphasize that it is important to recognize this rare variant of MF and to distinguish it from other aggressive cutaneous lymphomas to avoid aggressive treatment.

No MeSH data available.


Related in: MedlinePlus

The skin lesions in the buttocks and both thighs are erythematous to dusky brown.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC4215968&req=5

f1-kjpathol-48-5-390: The skin lesions in the buttocks and both thighs are erythematous to dusky brown.

Mentions: A 40-year-old male presented with a 5-year history of multiple round erythematous to dusky, brownish scaly patches with mild pruritus (Fig. 1). The skin involvement measured about 30% of total body surface. The lesions appeared first on the buttock and thigh, and lately on the upper arm. The skin lesions did not respond to topical corticosteroid treatment, at which time, he visited our hospital. A skin biopsy was taken from the thigh. The specimen showed a prominent band-like lymphocytic infiltration in the superficial dermis with epidermotropism (Fig. 2A). The epidermotropic lymphocytes were small- to medium-sized with an irregular nuclear membrane and coarse chromatin (Fig. 2B). The immunophenotype of the cells in the epidermis and a few cells in the superficial dermis were CD3+, CD4–, CD8+, CD56+, CD30–, and CD20– (Fig. 2C, D). The majority of lymphocytes in the superficial dermis were not atypical, in contrast to the epidermotropic lymphocytes, and were positive for CD4 and CD8. The neoplastic cells were positive for beta F1 (a marker of alpha/beta T lymphocytes) and granzyme B. An Epstein-Barr virus–encoded small non-polyadenylated RNA-1 (EBER-1) signal was not detected. Lactate dehydrogenase was elevated to 432 IU/L (range, 200 to 400 IU/L). Laboratory blood tests revealed an elevated, total cholesterol level of 235 mg/dL (range, 125 to 220 mg/mL). Complete blood cell count and other results of blood chemistry were within the normal range. The chest X-ray and positron emission tomography–computed tomography revealed no abnormal findings and there was no lymphadenopathy. The patient was diagnosed as having the stage IB, CD8+, CD56+ cytotoxic immunophenotype variant MF. He was treated with narrowband ultraviolet B therapy and his condition was stabilized.


Cytotoxic Variant of Mycosis Fungoides with CD8+ CD56+ Phenotype: A Case Report and Review of Literature.

Kim M, Park MI, Lim M, Kim J - Korean J Pathol (2014)

The skin lesions in the buttocks and both thighs are erythematous to dusky brown.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215968&req=5

f1-kjpathol-48-5-390: The skin lesions in the buttocks and both thighs are erythematous to dusky brown.
Mentions: A 40-year-old male presented with a 5-year history of multiple round erythematous to dusky, brownish scaly patches with mild pruritus (Fig. 1). The skin involvement measured about 30% of total body surface. The lesions appeared first on the buttock and thigh, and lately on the upper arm. The skin lesions did not respond to topical corticosteroid treatment, at which time, he visited our hospital. A skin biopsy was taken from the thigh. The specimen showed a prominent band-like lymphocytic infiltration in the superficial dermis with epidermotropism (Fig. 2A). The epidermotropic lymphocytes were small- to medium-sized with an irregular nuclear membrane and coarse chromatin (Fig. 2B). The immunophenotype of the cells in the epidermis and a few cells in the superficial dermis were CD3+, CD4–, CD8+, CD56+, CD30–, and CD20– (Fig. 2C, D). The majority of lymphocytes in the superficial dermis were not atypical, in contrast to the epidermotropic lymphocytes, and were positive for CD4 and CD8. The neoplastic cells were positive for beta F1 (a marker of alpha/beta T lymphocytes) and granzyme B. An Epstein-Barr virus–encoded small non-polyadenylated RNA-1 (EBER-1) signal was not detected. Lactate dehydrogenase was elevated to 432 IU/L (range, 200 to 400 IU/L). Laboratory blood tests revealed an elevated, total cholesterol level of 235 mg/dL (range, 125 to 220 mg/mL). Complete blood cell count and other results of blood chemistry were within the normal range. The chest X-ray and positron emission tomography–computed tomography revealed no abnormal findings and there was no lymphadenopathy. The patient was diagnosed as having the stage IB, CD8+, CD56+ cytotoxic immunophenotype variant MF. He was treated with narrowband ultraviolet B therapy and his condition was stabilized.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Chungnam National University Hospital, Daejeon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

The World Health Organization (WHO)-European Organization for Research and Treatment of Cancer (EORTC) classification for cutaneous lymphomas describes three types of cutaneous lymphomas that express CD56: 1) subcutaneous panniculitis-like T-cell lymphoma, 2) extranodal natural killer (NK)/T-cell lymphoma, nasal type, and 3) CD4+/CD56+ hematodermic neoplasm (blastic NKcell lymphoma)... However, the report does not mention, MF with CD56 expression... The lesions appeared first on the buttock and thigh, and lately on the upper arm... The skin lesions did not respond to topical corticosteroid treatment, at which time, he visited our hospital... Laboratory blood tests revealed an elevated, total cholesterol level of 235 mg/dL (range, 125 to 220 mg/mL)... Complete blood cell count and other results of blood chemistry were within the normal range... The patient was diagnosed as having the stage IB, CD8+, CD56+ cytotoxic immunophenotype variant MF... None of the cases, including our case, had an aggressive clinical course... This result suggests that CD56+ MF is a disease with good prognosis similar to classic MF... Several reports of MF with CD8+ and/or CD56+ expression have suggested that this variant would have no prognostic difference compared with classic MF... In our case, with the observed immunophenotype, we considered different diagnoses including primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma, primary cutaneous gamma/delta T-cell lymphoma, and extranodal NK/T-cell lymphoma, nasal type... In conclusion, we present a case of a cytotoxic variant of MF with a CD8+, CD56+ immunophenotype... We emphasize that it is important to recognize this rare variant of MF and to distinguish it from other aggressive cutaneous lymphomas to avoid aggressive treatment.

No MeSH data available.


Related in: MedlinePlus