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Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report.

Seok JY, Kang M, An J, Kim H, Lee KB, Cho HY - Korean J Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

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Papillary cystadenoma (PC) is an epithelial tumor believed to be of mesonephric origin that is found rarely in the female genital tract... We report a case of PC within the wall of the fallopian tube (rather than in the mesosalpinx or the broad ligament) in a patient with no clinical history of VHL... Ultrasonogram showed multiple solid masses on the uterus, suggesting leiomyomas... The laboratory findings were unremarkable, except for a slightly decreased hemoglobin level (11.7 g/dL)... The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2)... Psammoma bodies and mitotic figures were not found... The size of the tumors ranged from 3 cm to 6.5 cm (4.6±1.2 cm)... Twelve of 14 cases (86%) were associated with VHL either clinically or genetically... PCs, which are predominantly of clear cell type, can mimic metastatic RCC especially in a patient with a history of VHL... In atypical proliferative serous tumors, the papillae show hierarchical branching with epithelial stratification, ciliated cells, and psammoma bodies... Due to its rarity, the diagnosis of PC arising in the female genital tract is often challenging in daily practice... If the diagnosis of PC is made in a patient not known to have VHL, clinical investigations should be performed in order to confirm or rule out the possibility of VHL... Early diagnosis of VHL can enable the identification of potentially life-threatening lesions, including RCC, at curable stages.

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Immunohistochemically, the tumor cells show positivity for Cam5.2 (A), cytokeratin 7 (CK7) (B), vimentin (C), and CD10 (D). In contrast, the epithelial cells of the fallopian tube (lower left) show strong positivity for Cam5.2 and vimentin, variable positivity for CK7, and negativity for CD10.
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f3-kjpathol-48-5-382: Immunohistochemically, the tumor cells show positivity for Cam5.2 (A), cytokeratin 7 (CK7) (B), vimentin (C), and CD10 (D). In contrast, the epithelial cells of the fallopian tube (lower left) show strong positivity for Cam5.2 and vimentin, variable positivity for CK7, and negativity for CD10.

Mentions: Immunohistochemical examination was performed according to a previously reported method[7]. The tumor cells showed strong positivity for Cam5.2, cytokeratin (CK) 7, high-molecular weight CK, vimentin, and CD10 (Fig. 3) and weak positivity for CK19 and epithelial membrane antigen (EMA). The tumor cells were negative for α-methylacyl coenzyme A racemase, α-inhibin, calretinin, c-kit, actin, and human melanoma black 45.


Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report.

Seok JY, Kang M, An J, Kim H, Lee KB, Cho HY - Korean J Pathol (2014)

Immunohistochemically, the tumor cells show positivity for Cam5.2 (A), cytokeratin 7 (CK7) (B), vimentin (C), and CD10 (D). In contrast, the epithelial cells of the fallopian tube (lower left) show strong positivity for Cam5.2 and vimentin, variable positivity for CK7, and negativity for CD10.
© Copyright Policy
Related In: Results  -  Collection

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Show All Figures
getmorefigures.php?uid=PMC4215966&req=5

f3-kjpathol-48-5-382: Immunohistochemically, the tumor cells show positivity for Cam5.2 (A), cytokeratin 7 (CK7) (B), vimentin (C), and CD10 (D). In contrast, the epithelial cells of the fallopian tube (lower left) show strong positivity for Cam5.2 and vimentin, variable positivity for CK7, and negativity for CD10.
Mentions: Immunohistochemical examination was performed according to a previously reported method[7]. The tumor cells showed strong positivity for Cam5.2, cytokeratin (CK) 7, high-molecular weight CK, vimentin, and CD10 (Fig. 3) and weak positivity for CK19 and epithelial membrane antigen (EMA). The tumor cells were negative for α-methylacyl coenzyme A racemase, α-inhibin, calretinin, c-kit, actin, and human melanoma black 45.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Papillary cystadenoma (PC) is an epithelial tumor believed to be of mesonephric origin that is found rarely in the female genital tract... We report a case of PC within the wall of the fallopian tube (rather than in the mesosalpinx or the broad ligament) in a patient with no clinical history of VHL... Ultrasonogram showed multiple solid masses on the uterus, suggesting leiomyomas... The laboratory findings were unremarkable, except for a slightly decreased hemoglobin level (11.7 g/dL)... The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2)... Psammoma bodies and mitotic figures were not found... The size of the tumors ranged from 3 cm to 6.5 cm (4.6±1.2 cm)... Twelve of 14 cases (86%) were associated with VHL either clinically or genetically... PCs, which are predominantly of clear cell type, can mimic metastatic RCC especially in a patient with a history of VHL... In atypical proliferative serous tumors, the papillae show hierarchical branching with epithelial stratification, ciliated cells, and psammoma bodies... Due to its rarity, the diagnosis of PC arising in the female genital tract is often challenging in daily practice... If the diagnosis of PC is made in a patient not known to have VHL, clinical investigations should be performed in order to confirm or rule out the possibility of VHL... Early diagnosis of VHL can enable the identification of potentially life-threatening lesions, including RCC, at curable stages.

No MeSH data available.


Related in: MedlinePlus