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Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report.

Seok JY, Kang M, An J, Kim H, Lee KB, Cho HY - Korean J Pathol (2014)

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

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Papillary cystadenoma (PC) is an epithelial tumor believed to be of mesonephric origin that is found rarely in the female genital tract... We report a case of PC within the wall of the fallopian tube (rather than in the mesosalpinx or the broad ligament) in a patient with no clinical history of VHL... Ultrasonogram showed multiple solid masses on the uterus, suggesting leiomyomas... The laboratory findings were unremarkable, except for a slightly decreased hemoglobin level (11.7 g/dL)... The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2)... Psammoma bodies and mitotic figures were not found... The size of the tumors ranged from 3 cm to 6.5 cm (4.6±1.2 cm)... Twelve of 14 cases (86%) were associated with VHL either clinically or genetically... PCs, which are predominantly of clear cell type, can mimic metastatic RCC especially in a patient with a history of VHL... In atypical proliferative serous tumors, the papillae show hierarchical branching with epithelial stratification, ciliated cells, and psammoma bodies... Due to its rarity, the diagnosis of PC arising in the female genital tract is often challenging in daily practice... If the diagnosis of PC is made in a patient not known to have VHL, clinical investigations should be performed in order to confirm or rule out the possibility of VHL... Early diagnosis of VHL can enable the identification of potentially life-threatening lesions, including RCC, at curable stages.

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Low-power view of papillary cystadenoma shows an expansile growth pushing the lumen of the fallopian tube and blunting the plicae of the fallopian tube (lower left) (A). The tumor has many small cystic spaces containing papillary projections with glomeruloid features in some areas (B). The papillary fronds have monolayered cuboidal/columnar epithelium showing clear cytoplasm and a distinct cell border. The fibrovascular core contains a compact capillary network (C). Tumor cells with eosinophilic cytoplasm do not have cilia compared to ciliated tubal epithelial cells (lower left) (D).
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f2-kjpathol-48-5-382: Low-power view of papillary cystadenoma shows an expansile growth pushing the lumen of the fallopian tube and blunting the plicae of the fallopian tube (lower left) (A). The tumor has many small cystic spaces containing papillary projections with glomeruloid features in some areas (B). The papillary fronds have monolayered cuboidal/columnar epithelium showing clear cytoplasm and a distinct cell border. The fibrovascular core contains a compact capillary network (C). Tumor cells with eosinophilic cytoplasm do not have cilia compared to ciliated tubal epithelial cells (lower left) (D).

Mentions: The distal half of the left fallopian tube was slightly enlarged and the outer surface was smooth. On section, a solid grayishyellow mass that measured 3.9×1.4×1.3 cm was observed along the long axis of the fallopian tube (Fig. 1). On microscopic examination, a papillary cystic tumor was noted within the wall of the fallopian tube pushing against the surface epithelium. The papillae were short and blunted and lined by a single layer of bland nonciliated cuboidal cells with clear to eosinophilic cytoplasm. The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2). Psammoma bodies and mitotic figures were not found. There was a focus of endometriosis at the adhesion site. The resected uterus contained multiple leiomyomas and the myometrium showed adenomyosis. The right fallopian tube showed chronic inflammation.


Papillary cystadenoma of the fallopian tube not associated with von hippel-lindau disease: a case report.

Seok JY, Kang M, An J, Kim H, Lee KB, Cho HY - Korean J Pathol (2014)

Low-power view of papillary cystadenoma shows an expansile growth pushing the lumen of the fallopian tube and blunting the plicae of the fallopian tube (lower left) (A). The tumor has many small cystic spaces containing papillary projections with glomeruloid features in some areas (B). The papillary fronds have monolayered cuboidal/columnar epithelium showing clear cytoplasm and a distinct cell border. The fibrovascular core contains a compact capillary network (C). Tumor cells with eosinophilic cytoplasm do not have cilia compared to ciliated tubal epithelial cells (lower left) (D).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215966&req=5

f2-kjpathol-48-5-382: Low-power view of papillary cystadenoma shows an expansile growth pushing the lumen of the fallopian tube and blunting the plicae of the fallopian tube (lower left) (A). The tumor has many small cystic spaces containing papillary projections with glomeruloid features in some areas (B). The papillary fronds have monolayered cuboidal/columnar epithelium showing clear cytoplasm and a distinct cell border. The fibrovascular core contains a compact capillary network (C). Tumor cells with eosinophilic cytoplasm do not have cilia compared to ciliated tubal epithelial cells (lower left) (D).
Mentions: The distal half of the left fallopian tube was slightly enlarged and the outer surface was smooth. On section, a solid grayishyellow mass that measured 3.9×1.4×1.3 cm was observed along the long axis of the fallopian tube (Fig. 1). On microscopic examination, a papillary cystic tumor was noted within the wall of the fallopian tube pushing against the surface epithelium. The papillae were short and blunted and lined by a single layer of bland nonciliated cuboidal cells with clear to eosinophilic cytoplasm. The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2). Psammoma bodies and mitotic figures were not found. There was a focus of endometriosis at the adhesion site. The resected uterus contained multiple leiomyomas and the myometrium showed adenomyosis. The right fallopian tube showed chronic inflammation.

View Article: PubMed Central - PubMed

Affiliation: Departments of Pathology, Gachon University Gil Medical Center, Incheon, Korea.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Papillary cystadenoma (PC) is an epithelial tumor believed to be of mesonephric origin that is found rarely in the female genital tract... We report a case of PC within the wall of the fallopian tube (rather than in the mesosalpinx or the broad ligament) in a patient with no clinical history of VHL... Ultrasonogram showed multiple solid masses on the uterus, suggesting leiomyomas... The laboratory findings were unremarkable, except for a slightly decreased hemoglobin level (11.7 g/dL)... The nuclei were round with fine chromatin and occasional inconspicuous nucleoli (Fig. 2)... Psammoma bodies and mitotic figures were not found... The size of the tumors ranged from 3 cm to 6.5 cm (4.6±1.2 cm)... Twelve of 14 cases (86%) were associated with VHL either clinically or genetically... PCs, which are predominantly of clear cell type, can mimic metastatic RCC especially in a patient with a history of VHL... In atypical proliferative serous tumors, the papillae show hierarchical branching with epithelial stratification, ciliated cells, and psammoma bodies... Due to its rarity, the diagnosis of PC arising in the female genital tract is often challenging in daily practice... If the diagnosis of PC is made in a patient not known to have VHL, clinical investigations should be performed in order to confirm or rule out the possibility of VHL... Early diagnosis of VHL can enable the identification of potentially life-threatening lesions, including RCC, at curable stages.

No MeSH data available.


Related in: MedlinePlus