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Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.

Schubert C, Pryds A, Zeng S, Xie Y, Freund KB, Spaide RF, Merriam JC, Barbazetto I, Slakter JS, Chang S, Munch IC, Drack AV, Hernandez J, Yzer S, Merriam JE, Linneberg A, Larsen M, Yannuzzi LA, Mullins RF, Allikmets R - Hum. Mutat. (2014)

Bottom Line: We found a significant association of four common CDH5 SNPs with CSC in male patients in both cohorts.Two common intronic variants, rs7499886:A>G and rs1073584:C>T, exhibit strongly significant associations with CSC; P = 0.00012; odds ratio (OR) = 1.5; 95%CI [1.2;1.8], and P = 0.0014; OR = 0.70; 95%CI [0.57;0.87], respectively.We propose that genetically predetermined variation in CDH5, when combined with triggering events such as corticosteroid treatment or severe hormonal imbalance, underlie a substantial proportion of CSC in the male population.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.

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Related in: MedlinePlus

Reduced Cdh5 expression in mouse RPE-choroid-sclera in eyes injected with triamcinolone. When delivered by subretinal injection, triamcinolone significantly decreased expression of Cdh5 compared with the saline injected eyes, P = 0.02. In contrast, expression of the tight junction component Cldn1 increased in steroid treated eyes. No fold change is set to 0.
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fig05: Reduced Cdh5 expression in mouse RPE-choroid-sclera in eyes injected with triamcinolone. When delivered by subretinal injection, triamcinolone significantly decreased expression of Cdh5 compared with the saline injected eyes, P = 0.02. In contrast, expression of the tight junction component Cldn1 increased in steroid treated eyes. No fold change is set to 0.

Mentions: In order to determine whether corticosteroids reduce Cdh5 expression in vivo, mice were given subretinal injections of triamcinolone. Corticosteroid-injected eyes showed a significant decrease in Cdh5 mRNA levels in the posterior pole when compared with the saline injected eyes (P < 0.05, >70% reduction) (Fig.5). Interestingly, expression of claudin-1, a gene which product is a major component of tight junctions and is likely to increase resistance across the RPE, was increased by triamcinolone (Fig.5; P = .022, fold change = 2×).


Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.

Schubert C, Pryds A, Zeng S, Xie Y, Freund KB, Spaide RF, Merriam JC, Barbazetto I, Slakter JS, Chang S, Munch IC, Drack AV, Hernandez J, Yzer S, Merriam JE, Linneberg A, Larsen M, Yannuzzi LA, Mullins RF, Allikmets R - Hum. Mutat. (2014)

Reduced Cdh5 expression in mouse RPE-choroid-sclera in eyes injected with triamcinolone. When delivered by subretinal injection, triamcinolone significantly decreased expression of Cdh5 compared with the saline injected eyes, P = 0.02. In contrast, expression of the tight junction component Cldn1 increased in steroid treated eyes. No fold change is set to 0.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215937&req=5

fig05: Reduced Cdh5 expression in mouse RPE-choroid-sclera in eyes injected with triamcinolone. When delivered by subretinal injection, triamcinolone significantly decreased expression of Cdh5 compared with the saline injected eyes, P = 0.02. In contrast, expression of the tight junction component Cldn1 increased in steroid treated eyes. No fold change is set to 0.
Mentions: In order to determine whether corticosteroids reduce Cdh5 expression in vivo, mice were given subretinal injections of triamcinolone. Corticosteroid-injected eyes showed a significant decrease in Cdh5 mRNA levels in the posterior pole when compared with the saline injected eyes (P < 0.05, >70% reduction) (Fig.5). Interestingly, expression of claudin-1, a gene which product is a major component of tight junctions and is likely to increase resistance across the RPE, was increased by triamcinolone (Fig.5; P = .022, fold change = 2×).

Bottom Line: We found a significant association of four common CDH5 SNPs with CSC in male patients in both cohorts.Two common intronic variants, rs7499886:A>G and rs1073584:C>T, exhibit strongly significant associations with CSC; P = 0.00012; odds ratio (OR) = 1.5; 95%CI [1.2;1.8], and P = 0.0014; OR = 0.70; 95%CI [0.57;0.87], respectively.We propose that genetically predetermined variation in CDH5, when combined with triggering events such as corticosteroid treatment or severe hormonal imbalance, underlie a substantial proportion of CSC in the male population.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.

Show MeSH
Related in: MedlinePlus