Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.
Bottom Line: We found a significant association of four common CDH5 SNPs with CSC in male patients in both cohorts.Two common intronic variants, rs7499886:A>G and rs1073584:C>T, exhibit strongly significant associations with CSC; P = 0.00012; odds ratio (OR) = 1.5; 95%CI [1.2;1.8], and P = 0.0014; OR = 0.70; 95%CI [0.57;0.87], respectively.We propose that genetically predetermined variation in CDH5, when combined with triggering events such as corticosteroid treatment or severe hormonal imbalance, underlie a substantial proportion of CSC in the male population.
Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.Show MeSH
Related in: MedlinePlus
Mentions: In order to determine whether corticosteroids reduce Cdh5 expression in vivo, mice were given subretinal injections of triamcinolone. Corticosteroid-injected eyes showed a significant decrease in Cdh5 mRNA levels in the posterior pole when compared with the saline injected eyes (P < 0.05, >70% reduction) (Fig.5). Interestingly, expression of claudin-1, a gene which product is a major component of tight junctions and is likely to increase resistance across the RPE, was increased by triamcinolone (Fig.5; P = .022, fold change = 2×).
Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.