Cadherin 5 is regulated by corticosteroids and associated with central serous chorioretinopathy.
Bottom Line: We found a significant association of four common CDH5 SNPs with CSC in male patients in both cohorts.Two common intronic variants, rs7499886:A>G and rs1073584:C>T, exhibit strongly significant associations with CSC; P = 0.00012; odds ratio (OR) = 1.5; 95%CI [1.2;1.8], and P = 0.0014; OR = 0.70; 95%CI [0.57;0.87], respectively.We propose that genetically predetermined variation in CDH5, when combined with triggering events such as corticosteroid treatment or severe hormonal imbalance, underlie a substantial proportion of CSC in the male population.
Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.Show MeSH
Related in: MedlinePlus
Mentions: The C166 endothelial cell line was exposed to prednisolone for 6 hr. Treatment resulted in significantly reduced Cdh5 expression (fold change >-2.5, P < 0.05) at all tested concentrations (Fig.3A) when normalized to expression of Rpl19. In contrast, treatment of C166 EC with testosterone, a steroid that has not been linked to changes in CSC incidence or severity, shows no significant change in CDH5 expression.
Affiliation: Department of Ophthalmology, Columbia University, New York City, New York.