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Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.

Weng PH, Huang YL, Page JH, Chen JH, Xu J, Koutros S, Berndt S, Chanock S, Yeager M, Witte JS, Eeles RA, Easton DF, Neal DE, Donovan J, Hamdy FC, Muir KR, Giles G, Severi G, Smith JR, Balistreri CR, Shui IM, Chen YC - PLoS ONE (2014)

Bottom Line: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973).Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953).Meta-regression revealed that study type was not a significant source of between-study heterogeneity.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

ABSTRACT

Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.

Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.

Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.

Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.

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Related in: MedlinePlus

Forest plot examines relationship between TLR4 SNPs and risk of aggressive prostate cancer.Odds ratios and weights were demonstrated for each individual study and for the pooled analysis, assuming a dominant model. SNPs that were evaluated by at least 4 studies were shown here.
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pone-0110569-g003: Forest plot examines relationship between TLR4 SNPs and risk of aggressive prostate cancer.Odds ratios and weights were demonstrated for each individual study and for the pooled analysis, assuming a dominant model. SNPs that were evaluated by at least 4 studies were shown here.

Mentions: This meta-analysis was reported according to the PRISMA checklist [43] (Checklist S1). Using random effects meta-analysis, the ten TLR4 SNPs (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1444973) were not associated with the risk of aggressive PCa regardless of the inheritance model used (Table 3, Figure 3). The meta-analysis was also performed for another ten SNPs which were reported by three included studies (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953) (Table S1). None of the SNPs revealed significant association with aggressive PCa.


Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.

Weng PH, Huang YL, Page JH, Chen JH, Xu J, Koutros S, Berndt S, Chanock S, Yeager M, Witte JS, Eeles RA, Easton DF, Neal DE, Donovan J, Hamdy FC, Muir KR, Giles G, Severi G, Smith JR, Balistreri CR, Shui IM, Chen YC - PLoS ONE (2014)

Forest plot examines relationship between TLR4 SNPs and risk of aggressive prostate cancer.Odds ratios and weights were demonstrated for each individual study and for the pooled analysis, assuming a dominant model. SNPs that were evaluated by at least 4 studies were shown here.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215920&req=5

pone-0110569-g003: Forest plot examines relationship between TLR4 SNPs and risk of aggressive prostate cancer.Odds ratios and weights were demonstrated for each individual study and for the pooled analysis, assuming a dominant model. SNPs that were evaluated by at least 4 studies were shown here.
Mentions: This meta-analysis was reported according to the PRISMA checklist [43] (Checklist S1). Using random effects meta-analysis, the ten TLR4 SNPs (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1444973) were not associated with the risk of aggressive PCa regardless of the inheritance model used (Table 3, Figure 3). The meta-analysis was also performed for another ten SNPs which were reported by three included studies (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953) (Table S1). None of the SNPs revealed significant association with aggressive PCa.

Bottom Line: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973).Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953).Meta-regression revealed that study type was not a significant source of between-study heterogeneity.

View Article: PubMed Central - PubMed

Affiliation: Department of Family Medicine, Taiwan Adventist Hospital, Taipei, Taiwan; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

ABSTRACT

Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.

Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.

Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.

Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.

Show MeSH
Related in: MedlinePlus