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Imparting superhydrophobicity to biodegradable poly(lactide-co-glycolide) electrospun meshes.

Kaplan JA, Lei H, Liu R, Padera R, Colson YL, Grinstaff MW - Biomacromolecules (2014)

Bottom Line: Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers.Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties.Contact angles as high as 160° are obtained with 30% polymer dopant.

View Article: PubMed Central - PubMed

Affiliation: Departments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United States.

ABSTRACT
The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.

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Synthesis of Poly(ester carbonate) Copolymers
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Imparting superhydrophobicity to biodegradable poly(lactide-co-glycolide) electrospun meshes.

Kaplan JA, Lei H, Liu R, Padera R, Colson YL, Grinstaff MW - Biomacromolecules (2014)

Synthesis of Poly(ester carbonate) Copolymers
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC4215912&req=5

sch1: Synthesis of Poly(ester carbonate) Copolymers
Bottom Line: Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers.Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties.Contact angles as high as 160° are obtained with 30% polymer dopant.

View Article: PubMed Central - PubMed

Affiliation: Departments of Biomedical Engineering and Chemistry, Boston University , Boston, Massachusetts 02215, United States.

ABSTRACT
The synthesis of a family of new poly(lactic acid-co-glycerol monostearate) (PLA-PGC18) copolymers and their use as biodegradable polymer dopants is reported to enhance the hydrophobicity of poly(lactic acid-co-glycolic acid) (PLGA) nonwoven meshes. Solutions of PLGA are doped with PLA-PGC18 and electrospun to form meshes with micrometer-sized fibers. Fiber diameter, percent doping, and copolymer composition influence the nonwetting nature of the meshes and alter their mechanical (tensile) properties. Contact angles as high as 160° are obtained with 30% polymer dopant. Lastly, these meshes are nontoxic, as determined by an NIH/3T3 cell biocompatibility assay, and displayed a minimal foreign body response when implanted in mice. In summary, a general method for constructing biodegradable fibrous meshes with tunable hydrophobicity is described for use in tissue engineering and drug delivery applications.

Show MeSH
Related in: MedlinePlus